@article{5e5690c8650f470787d0ee782c43303d,
title = "Daily energy expenditure through the human life course",
abstract = "Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.",
author = "Herman Pontzer and Yosuke Yamada and Hiroyuki Sagayama and Ainslie, {Philip N.} and Andersen, {Lene F.} and Anderson, {Liam J.} and Lenore Arab and Issaad Baddou and Kweku Bedu-Addo and Blaak, {Ellen E.} and Stephane Blanc and Bonomi, {Alberto G.} and Bouten, {Carlijn V.C.} and Pascal Bovet and Buchowski, {Maciej S.} and Butte, {Nancy F.} and Camps, {Stefan G.} and Close, {Graeme L.} and Cooper, {Jamie A.} and Richard Cooper and Das, {Sai Krupa} and Dugas, {Lara R.} and Ulf Ekelund and Sonja Entringer and Terrence Forrester and Fudge, {Barry W.} and Goris, {Annelies H.} and Michael Gurven and Catherine Hambly and {El Hamdouchi}, Asmaa and Hoos, {Marjije B.} and Sumei Hu and Noorjehan Joonas and Joosen, {Annemiek M.} and Peter Katzmarzyk and Kempen, {Kitty P.} and Misaka Kimura and Kraus, {William E.} and Kushner, {Robert F.} and Lambert, {Estelle V.} and Leonard, {William R.} and Nader Lessan and Corby Martin and Medin, {Anine C.} and Meijer, {Erwin P.} and Morehen, {James C.} and Morton, {James P.} and Neuhouser, {Marian L.} and Xueying Zhang and Speakman, {John R.} and {IAEA DLW Database Consortium} and Luke, {Amy H.} and Jennifer Rood and Schoeller, {Dale A} and Westerterp, {Klaas R.} and Wong, {William W}",
note = "Funding Information: The IAEA Doubly Labeled Water (DLW) Database is generously supported by the IAEA, Taiyo Nippon Sanso, and SERCON. The authors also gratefully acknowledge funding from the US National Science Foundation (BCS-1824466) awarded to H.P. The funders played no role in the content of this manuscript. ",
year = "2021",
month = aug,
day = "13",
doi = "10.1126/science.abe5017",
language = "English",
volume = "373",
pages = "808--812",
journal = "Science",
issn = "0036-8075",
publisher = "AMER ASSOC ADVANCEMENT SCIENCE",
number = "6556",
}
