Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study

A L Malizia; V J Cunningham; C J Bell; P F Liddle; T Jones; D J Nutt

Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study

A L Malizia, V J Cunningham, C J Bell, P F Liddle, T Jones, D J Nutt

Research output: Contribution to journal › Article › peer-review

Abstract

Positron emission tomography (PET) allows the measurement of benzodiazepine-gamma-aminobutyric acidA (GABA(A)) receptor kinetics. We employed flumazenil radiolabeled with carbon 11, a radioligand that labels the benzodiazepine site on the GABA(A) receptor, and fully quantitative, high-sensitivity PET to test the hypothesis that central benzodiazepine site binding is decreased in medication-free patients with panic disorder.

Original language	English
Pages (from-to)	715-20
Number of pages	6
Journal	Archives of General Psychiatry
Volume	55
Issue number	8
Publication status	Published - 1998

Keywords

Adult
Aged
Brain
Carbon Radioisotopes
Cerebral Cortex
Female
Flumazenil
Functional Laterality
Humans
Male
Middle Aged
Panic Disorder
Personality Inventory
Receptors, GABA-A
Sex Factors
Tissue Distribution
Tomography, Emission-Computed
gamma-Aminobutyric Acid

Cite this

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title = "Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study",

abstract = "Positron emission tomography (PET) allows the measurement of benzodiazepine-gamma-aminobutyric acidA (GABA(A)) receptor kinetics. We employed flumazenil radiolabeled with carbon 11, a radioligand that labels the benzodiazepine site on the GABA(A) receptor, and fully quantitative, high-sensitivity PET to test the hypothesis that central benzodiazepine site binding is decreased in medication-free patients with panic disorder.",

keywords = "Adult, Aged, Brain, Carbon Radioisotopes, Cerebral Cortex, Female, Flumazenil, Functional Laterality, Humans, Male, Middle Aged, Panic Disorder, Personality Inventory, Receptors, GABA-A, Sex Factors, Tissue Distribution, Tomography, Emission-Computed, gamma-Aminobutyric Acid",

author = "Malizia, {A L} and Cunningham, {V J} and Bell, {C J} and Liddle, {P F} and T Jones and Nutt, {D J}",

year = "1998",

language = "English",

volume = "55",

pages = "715--20",

journal = "Archives of General Psychiatry",

issn = "0003-990X",

publisher = "American Medical Association",

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TY - JOUR

T1 - Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study

AU - Malizia, A L

AU - Cunningham, V J

AU - Bell, C J

AU - Liddle, P F

AU - Jones, T

AU - Nutt, D J

PY - 1998

Y1 - 1998

N2 - Positron emission tomography (PET) allows the measurement of benzodiazepine-gamma-aminobutyric acidA (GABA(A)) receptor kinetics. We employed flumazenil radiolabeled with carbon 11, a radioligand that labels the benzodiazepine site on the GABA(A) receptor, and fully quantitative, high-sensitivity PET to test the hypothesis that central benzodiazepine site binding is decreased in medication-free patients with panic disorder.

AB - Positron emission tomography (PET) allows the measurement of benzodiazepine-gamma-aminobutyric acidA (GABA(A)) receptor kinetics. We employed flumazenil radiolabeled with carbon 11, a radioligand that labels the benzodiazepine site on the GABA(A) receptor, and fully quantitative, high-sensitivity PET to test the hypothesis that central benzodiazepine site binding is decreased in medication-free patients with panic disorder.

KW - Adult

KW - Aged

KW - Brain

KW - Carbon Radioisotopes

KW - Cerebral Cortex

KW - Female

KW - Flumazenil

KW - Functional Laterality

KW - Humans

KW - Male

KW - Middle Aged

KW - Panic Disorder

KW - Personality Inventory

KW - Receptors, GABA-A

KW - Sex Factors

KW - Tissue Distribution

KW - Tomography, Emission-Computed

KW - gamma-Aminobutyric Acid

M3 - Article

C2 - 9707382

SN - 0003-990X

VL - 55

SP - 715

EP - 720

JO - Archives of General Psychiatry

JF - Archives of General Psychiatry

IS - 8

ER -

Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study

Abstract

Keywords

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