Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study

A L Malizia, V J Cunningham, C J Bell, P F Liddle, T Jones, D J Nutt

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323 Citations (Scopus)

Abstract

Positron emission tomography (PET) allows the measurement of benzodiazepine-gamma-aminobutyric acidA (GABA(A)) receptor kinetics. We employed flumazenil radiolabeled with carbon 11, a radioligand that labels the benzodiazepine site on the GABA(A) receptor, and fully quantitative, high-sensitivity PET to test the hypothesis that central benzodiazepine site binding is decreased in medication-free patients with panic disorder.
Original languageEnglish
Pages (from-to)715-20
Number of pages6
JournalArchives of General Psychiatry
Volume55
Issue number8
Publication statusPublished - 1998

Keywords

  • Adult
  • Aged
  • Brain
  • Carbon Radioisotopes
  • Cerebral Cortex
  • Female
  • Flumazenil
  • Functional Laterality
  • Humans
  • Male
  • Middle Aged
  • Panic Disorder
  • Personality Inventory
  • Receptors, GABA-A
  • Sex Factors
  • Tissue Distribution
  • Tomography, Emission-Computed
  • gamma-Aminobutyric Acid

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    Malizia, A. L., Cunningham, V. J., Bell, C. J., Liddle, P. F., Jones, T., & Nutt, D. J. (1998). Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study. Archives of General Psychiatry, 55(8), 715-20.