Decreased phospholipid polyunsaturated fatty acid content and superoxide dismutase activity in cardiac muscle of malignant hyperthermia-susceptible swine

Klaus W. J. Wahle, Philip C. Morrice, John R. Arthur, Garry G. Duthie

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Homogenates of cardiac left ventricle from malignant hyperthermia-susceptible (MHS) pigs produced a circa 72% more pentane than those from malignant hyperthermia-resistant (MHR) animals, indicating enhanced peroxidation of n-6 fatty acids. This is consistent with the observed circa 70% decrease in total phospholipid polyunsaturated fatty acids (PUFA) in MHS compared with MHR tissue, a decrease mainly due to the quantitatively greater loss of n-6 PUFA. Although the percentage loss of n-3 PUFA was greater than that of n-6 PUFA (90% vs 60%), absolute amounts were insufficient to register as ethane production. Three-fold greater phospholipid content of MHS compared with MHR ventricles indicates reduced neutral lipid content probably due to increased catecholamine stimulation. These findings were associated with a small but significant decrease in superoxide dismutase activity in MHS tissues.

Original languageEnglish
Pages (from-to)283-286
Number of pages4
JournalComparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Volume112
Issue number2
DOIs
Publication statusPublished - Oct 1995

Keywords

  • malignant hyperthermia
  • lipid peroxidation
  • cardiac muscle
  • superoxide dismutase
  • essential fatty acids
  • lipid-peroxidation
  • skeletal-muscle
  • vitamin-E
  • tissue
  • pigs

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