Abstract
Homogenates of cardiac left ventricle from malignant hyperthermia-susceptible (MHS) pigs produced a circa 72% more pentane than those from malignant hyperthermia-resistant (MHR) animals, indicating enhanced peroxidation of n-6 fatty acids. This is consistent with the observed circa 70% decrease in total phospholipid polyunsaturated fatty acids (PUFA) in MHS compared with MHR tissue, a decrease mainly due to the quantitatively greater loss of n-6 PUFA. Although the percentage loss of n-3 PUFA was greater than that of n-6 PUFA (90% vs 60%), absolute amounts were insufficient to register as ethane production. Three-fold greater phospholipid content of MHS compared with MHR ventricles indicates reduced neutral lipid content probably due to increased catecholamine stimulation. These findings were associated with a small but significant decrease in superoxide dismutase activity in MHS tissues.
Original language | English |
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Pages (from-to) | 283-286 |
Number of pages | 4 |
Journal | Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology |
Volume | 112 |
Issue number | 2 |
DOIs | |
Publication status | Published - Oct 1995 |
Keywords
- malignant hyperthermia
- lipid peroxidation
- cardiac muscle
- superoxide dismutase
- essential fatty acids
- lipid-peroxidation
- skeletal-muscle
- vitamin-E
- tissue
- pigs