Decreased phospholipid polyunsaturated fatty acid content and superoxide dismutase activity in cardiac muscle of malignant hyperthermia-susceptible swine

Klaus W. J. Wahle, Philip C. Morrice, John R. Arthur, Garry G. Duthie

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Homogenates of cardiac left ventricle from malignant hyperthermia-susceptible (MHS) pigs produced a circa 72% more pentane than those from malignant hyperthermia-resistant (MHR) animals, indicating enhanced peroxidation of n-6 fatty acids. This is consistent with the observed circa 70% decrease in total phospholipid polyunsaturated fatty acids (PUFA) in MHS compared with MHR tissue, a decrease mainly due to the quantitatively greater loss of n-6 PUFA. Although the percentage loss of n-3 PUFA was greater than that of n-6 PUFA (90% vs 60%), absolute amounts were insufficient to register as ethane production. Three-fold greater phospholipid content of MHS compared with MHR ventricles indicates reduced neutral lipid content probably due to increased catecholamine stimulation. These findings were associated with a small but significant decrease in superoxide dismutase activity in MHS tissues.

Original languageEnglish
Pages (from-to)283-286
Number of pages4
JournalComparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Volume112
Issue number2
DOIs
Publication statusPublished - Oct 1995

Keywords

  • malignant hyperthermia
  • lipid peroxidation
  • cardiac muscle
  • superoxide dismutase
  • essential fatty acids
  • lipid-peroxidation
  • skeletal-muscle
  • vitamin-E
  • tissue
  • pigs

Cite this

@article{011d68c949e84c53a4345242c7cd8ade,
title = "Decreased phospholipid polyunsaturated fatty acid content and superoxide dismutase activity in cardiac muscle of malignant hyperthermia-susceptible swine",
abstract = "Homogenates of cardiac left ventricle from malignant hyperthermia-susceptible (MHS) pigs produced a circa 72{\%} more pentane than those from malignant hyperthermia-resistant (MHR) animals, indicating enhanced peroxidation of n-6 fatty acids. This is consistent with the observed circa 70{\%} decrease in total phospholipid polyunsaturated fatty acids (PUFA) in MHS compared with MHR tissue, a decrease mainly due to the quantitatively greater loss of n-6 PUFA. Although the percentage loss of n-3 PUFA was greater than that of n-6 PUFA (90{\%} vs 60{\%}), absolute amounts were insufficient to register as ethane production. Three-fold greater phospholipid content of MHS compared with MHR ventricles indicates reduced neutral lipid content probably due to increased catecholamine stimulation. These findings were associated with a small but significant decrease in superoxide dismutase activity in MHS tissues.",
keywords = "malignant hyperthermia, lipid peroxidation, cardiac muscle, superoxide dismutase, essential fatty acids, lipid-peroxidation, skeletal-muscle, vitamin-E, tissue, pigs",
author = "Wahle, {Klaus W. J.} and Morrice, {Philip C.} and Arthur, {John R.} and Duthie, {Garry G.}",
year = "1995",
month = "10",
doi = "10.1016/0305-0491(95)00072-0",
language = "English",
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pages = "283--286",
journal = "Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology",
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TY - JOUR

T1 - Decreased phospholipid polyunsaturated fatty acid content and superoxide dismutase activity in cardiac muscle of malignant hyperthermia-susceptible swine

AU - Wahle, Klaus W. J.

AU - Morrice, Philip C.

AU - Arthur, John R.

AU - Duthie, Garry G.

PY - 1995/10

Y1 - 1995/10

N2 - Homogenates of cardiac left ventricle from malignant hyperthermia-susceptible (MHS) pigs produced a circa 72% more pentane than those from malignant hyperthermia-resistant (MHR) animals, indicating enhanced peroxidation of n-6 fatty acids. This is consistent with the observed circa 70% decrease in total phospholipid polyunsaturated fatty acids (PUFA) in MHS compared with MHR tissue, a decrease mainly due to the quantitatively greater loss of n-6 PUFA. Although the percentage loss of n-3 PUFA was greater than that of n-6 PUFA (90% vs 60%), absolute amounts were insufficient to register as ethane production. Three-fold greater phospholipid content of MHS compared with MHR ventricles indicates reduced neutral lipid content probably due to increased catecholamine stimulation. These findings were associated with a small but significant decrease in superoxide dismutase activity in MHS tissues.

AB - Homogenates of cardiac left ventricle from malignant hyperthermia-susceptible (MHS) pigs produced a circa 72% more pentane than those from malignant hyperthermia-resistant (MHR) animals, indicating enhanced peroxidation of n-6 fatty acids. This is consistent with the observed circa 70% decrease in total phospholipid polyunsaturated fatty acids (PUFA) in MHS compared with MHR tissue, a decrease mainly due to the quantitatively greater loss of n-6 PUFA. Although the percentage loss of n-3 PUFA was greater than that of n-6 PUFA (90% vs 60%), absolute amounts were insufficient to register as ethane production. Three-fold greater phospholipid content of MHS compared with MHR ventricles indicates reduced neutral lipid content probably due to increased catecholamine stimulation. These findings were associated with a small but significant decrease in superoxide dismutase activity in MHS tissues.

KW - malignant hyperthermia

KW - lipid peroxidation

KW - cardiac muscle

KW - superoxide dismutase

KW - essential fatty acids

KW - lipid-peroxidation

KW - skeletal-muscle

KW - vitamin-E

KW - tissue

KW - pigs

U2 - 10.1016/0305-0491(95)00072-0

DO - 10.1016/0305-0491(95)00072-0

M3 - Article

VL - 112

SP - 283

EP - 286

JO - Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology

JF - Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology

SN - 1096-4959

IS - 2

ER -