Defining clinical subtypes of adult asthma using electronic health records: analysis of a large UK primary care database with external validation

Elsie MF Horne* (Corresponding Author), Susannah Mclean, Mohammad A Alsallakh, Gwyneth A Davies, David Price, Aziz Sheikh, Athanasios Tsanas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction
Asthma is one of the commonest chronic conditions in the world. Subtypes of asthma have been defined, typically from clinical datasets on small, well-characterised subpopulations of asthma patients. We sought to define asthma subtypes from large longitudinal primary care electronic health records (EHRs) using cluster analysis.
Methods
In this retrospective cohort study, we extracted asthma subpopulations from the Optimum Patient Care Research Database (OPCRD) to robustly train and test algorithms, and externally validated findings in the Secure Anonymised Information Linkage (SAIL) Databank. In both databases, we identified adults with an asthma diagnosis code recorded in the three years prior to an index date. Train and test datasets were selected from OPCRD using an index date of Jan 1, 2016. Two internal validation datasets were selected from OPCRD using
index dates of Jan 1, 2017 and 2018. Three external validation datasets were selected from SAIL using index dates of Jan 1, 2016, 2017 and 2018. Each dataset comprised 50,000 randomly selected non-overlapping patients. Subtypes were defined by applying multiple correspondence analysis and k-means cluster analysis to the train dataset, and were validated in the internal and external validation datasets.

Results
We defined six asthma subtypes with clear clinical interpretability: low inhaled
corticosteroid (ICS) use and low healthcare utilisation (30% of patients); low-to-medium ICS use (36%); low-to-medium ICS use and comorbidities (12%); varied ICS use and comorbid chronic obstructive pulmonary disease (4%); high (10%) and very high ICS use (7%). The subtypes were replicated with high accuracy in internal (91-92%) and external (84-86%) datasets.
Conclusion
Asthma subtypes derived and validated in large independent EHR databases were primarily defined by level of ICS use, level of healthcare use, and presence of comorbidities. This has important clinical implications towards defining asthma subtypes, facilitating patient stratification, and developing more personalised monitoring and treatment strategies.
Original languageEnglish
Article number104942
Number of pages11
JournalInternational Journal of Medical Informatics
Volume170
Early online date16 Dec 2022
DOIs
Publication statusE-pub ahead of print - 16 Dec 2022

Keywords

  • Asthma
  • Electronic health records
  • Cluster Analysis

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