Dermacozines H-J Isolated from a Deep-Sea Strain of Dermacoccus abyssi from Mariana Trench Sediments

Marcell Wagner, Wael M. Abdel-Mageed, Rainer Ebel, Alan T. Bull, Michael Goodfellow, Hans-Peter Fiedler*, Marcel Jaspars

*Corresponding author for this work

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new Pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H-J (1-3). Extensive use was made of ID and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 mu M.

Original languageEnglish
Pages (from-to)416-420
Number of pages5
JournalJournal of Natural Products
Volume77
Issue number2
Early online date5 Feb 2014
DOIs
Publication statusPublished - 22 Feb 2014

Keywords

  • marine-sediments
  • challenger deep
  • streptomyces
  • actinobacteria
  • diversity

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