Dermacozines H-J Isolated from a Deep-Sea Strain of Dermacoccus abyssi from Mariana Trench Sediments

Marcell Wagner; Wael M. Abdel-Mageed; Rainer Ebel; Alan T. Bull; Michael Goodfellow; Hans-Peter Fiedler; Marcel Jaspars

doi:10.1021/np400952d

Dermacozines H-J Isolated from a Deep-Sea Strain of Dermacoccus abyssi from Mariana Trench Sediments

Marcell Wagner, Wael M. Abdel-Mageed, Rainer Ebel, Alan T. Bull, Michael Goodfellow, Hans-Peter Fiedler^*, Marcel Jaspars

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new Pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H-J (1-3). Extensive use was made of ID and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 mu M.

Original language	English
Pages (from-to)	416-420
Number of pages	5
Journal	Journal of Natural Products
Volume	77
Issue number	2
Early online date	5 Feb 2014
DOIs	https://doi.org/10.1021/np400952d
Publication status	Published - 22 Feb 2014

Bibliographical note

ACKNOWLEDGMENTS
The authors are grateful to the Kaiko operation team and the crew of M.S. Yokosuka, JAMSTEC, Yokosuka, Japan, for collecting sediment samples. M.W. thanks the Jürgen-ManchotFoundation for a generous scholarship and Max-BuchnerForschungsstiftung for support of consumables. M.J. is the recipient of a BBSRC Research Development Fellowship. The authors thank Mr A. Kulik, University of Tübingen, Germany, for assistance in fermentation and HPLC-ESIMS analysis. The
authors are grateful to EPSRC National Mass Spectrometric Centre, University of Wales, Swansea, for mass spectrometric analysis.

Keywords

marine-sediments
challenger deep
streptomyces
actinobacteria
diversity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np400952d

Rainer Ebel
- School of Natural & Computing Sciences, Chemistry - Personal Chair
Person: Academic

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title = "Dermacozines H-J Isolated from a Deep-Sea Strain of Dermacoccus abyssi from Mariana Trench Sediments",

abstract = "Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new Pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H-J (1-3). Extensive use was made of ID and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 mu M.",

keywords = "marine-sediments, challenger deep, streptomyces, actinobacteria, diversity",

author = "Marcell Wagner and Abdel-Mageed, {Wael M.} and Rainer Ebel and Bull, {Alan T.} and Michael Goodfellow and Hans-Peter Fiedler and Marcel Jaspars",

note = "ACKNOWLEDGMENTS The authors are grateful to the Kaiko operation team and the crew of M.S. Yokosuka, JAMSTEC, Yokosuka, Japan, for collecting sediment samples. M.W. thanks the J{\"u}rgen-ManchotFoundation for a generous scholarship and Max-BuchnerForschungsstiftung for support of consumables. M.J. is the recipient of a BBSRC Research Development Fellowship. The authors thank Mr A. Kulik, University of T{\"u}bingen, Germany, for assistance in fermentation and HPLC-ESIMS analysis. The authors are grateful to EPSRC National Mass Spectrometric Centre, University of Wales, Swansea, for mass spectrometric analysis.",

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T1 - Dermacozines H-J Isolated from a Deep-Sea Strain of Dermacoccus abyssi from Mariana Trench Sediments

AU - Wagner, Marcell

AU - Abdel-Mageed, Wael M.

AU - Ebel, Rainer

AU - Bull, Alan T.

AU - Goodfellow, Michael

AU - Fiedler, Hans-Peter

AU - Jaspars, Marcel

N1 - ACKNOWLEDGMENTS The authors are grateful to the Kaiko operation team and the crew of M.S. Yokosuka, JAMSTEC, Yokosuka, Japan, for collecting sediment samples. M.W. thanks the Jürgen-ManchotFoundation for a generous scholarship and Max-BuchnerForschungsstiftung for support of consumables. M.J. is the recipient of a BBSRC Research Development Fellowship. The authors thank Mr A. Kulik, University of Tübingen, Germany, for assistance in fermentation and HPLC-ESIMS analysis. The authors are grateful to EPSRC National Mass Spectrometric Centre, University of Wales, Swansea, for mass spectrometric analysis.

PY - 2014/2/22

Y1 - 2014/2/22

N2 - Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new Pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H-J (1-3). Extensive use was made of ID and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 mu M.

AB - Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new Pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H-J (1-3). Extensive use was made of ID and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 mu M.

KW - marine-sediments

KW - challenger deep

KW - streptomyces

KW - actinobacteria

KW - diversity

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 2

ER -

Dermacozines H-J Isolated from a Deep-Sea Strain of Dermacoccus abyssi from Mariana Trench Sediments

Abstract

Bibliographical note

Keywords

UN SDGs

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Rainer Ebel

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