Dermacozines H-J Isolated from a Deep-Sea Strain of Dermacoccus abyssi from Mariana Trench Sediments

Marcell Wagner, Wael M. Abdel-Mageed, Rainer Ebel, Alan T. Bull, Michael Goodfellow, Hans-Peter Fiedler*, Marcel Jaspars

*Corresponding author for this work

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new Pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H-J (1-3). Extensive use was made of ID and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 mu M.

Original languageEnglish
Pages (from-to)416-420
Number of pages5
JournalJournal of Natural Products
Volume77
Issue number2
Early online date5 Feb 2014
DOIs
Publication statusPublished - 22 Feb 2014

Keywords

  • marine-sediments
  • challenger deep
  • streptomyces
  • actinobacteria
  • diversity

Cite this

Dermacozines H-J Isolated from a Deep-Sea Strain of Dermacoccus abyssi from Mariana Trench Sediments. / Wagner, Marcell; Abdel-Mageed, Wael M.; Ebel, Rainer; Bull, Alan T.; Goodfellow, Michael; Fiedler, Hans-Peter; Jaspars, Marcel.

In: Journal of Natural Products, Vol. 77, No. 2, 22.02.2014, p. 416-420.

Research output: Contribution to journalArticle

Wagner, Marcell ; Abdel-Mageed, Wael M. ; Ebel, Rainer ; Bull, Alan T. ; Goodfellow, Michael ; Fiedler, Hans-Peter ; Jaspars, Marcel. / Dermacozines H-J Isolated from a Deep-Sea Strain of Dermacoccus abyssi from Mariana Trench Sediments. In: Journal of Natural Products. 2014 ; Vol. 77, No. 2. pp. 416-420.
@article{9b03400f5c464e6f8e4e0ebe061a5071,
title = "Dermacozines H-J Isolated from a Deep-Sea Strain of Dermacoccus abyssi from Mariana Trench Sediments",
abstract = "Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new Pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H-J (1-3). Extensive use was made of ID and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 mu M.",
keywords = "marine-sediments, challenger deep, streptomyces, actinobacteria, diversity",
author = "Marcell Wagner and Abdel-Mageed, {Wael M.} and Rainer Ebel and Bull, {Alan T.} and Michael Goodfellow and Hans-Peter Fiedler and Marcel Jaspars",
note = "ACKNOWLEDGMENTS The authors are grateful to the Kaiko operation team and the crew of M.S. Yokosuka, JAMSTEC, Yokosuka, Japan, for collecting sediment samples. M.W. thanks the Jürgen-ManchotFoundation for a generous scholarship and Max-BuchnerForschungsstiftung for support of consumables. M.J. is the recipient of a BBSRC Research Development Fellowship. The authors thank Mr A. Kulik, University of Tübingen, Germany, for assistance in fermentation and HPLC-ESIMS analysis. The authors are grateful to EPSRC National Mass Spectrometric Centre, University of Wales, Swansea, for mass spectrometric analysis.",
year = "2014",
month = "2",
day = "22",
doi = "10.1021/np400952d",
language = "English",
volume = "77",
pages = "416--420",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "2",

}

TY - JOUR

T1 - Dermacozines H-J Isolated from a Deep-Sea Strain of Dermacoccus abyssi from Mariana Trench Sediments

AU - Wagner, Marcell

AU - Abdel-Mageed, Wael M.

AU - Ebel, Rainer

AU - Bull, Alan T.

AU - Goodfellow, Michael

AU - Fiedler, Hans-Peter

AU - Jaspars, Marcel

N1 - ACKNOWLEDGMENTS The authors are grateful to the Kaiko operation team and the crew of M.S. Yokosuka, JAMSTEC, Yokosuka, Japan, for collecting sediment samples. M.W. thanks the Jürgen-ManchotFoundation for a generous scholarship and Max-BuchnerForschungsstiftung for support of consumables. M.J. is the recipient of a BBSRC Research Development Fellowship. The authors thank Mr A. Kulik, University of Tübingen, Germany, for assistance in fermentation and HPLC-ESIMS analysis. The authors are grateful to EPSRC National Mass Spectrometric Centre, University of Wales, Swansea, for mass spectrometric analysis.

PY - 2014/2/22

Y1 - 2014/2/22

N2 - Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new Pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H-J (1-3). Extensive use was made of ID and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 mu M.

AB - Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new Pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H-J (1-3). Extensive use was made of ID and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 mu M.

KW - marine-sediments

KW - challenger deep

KW - streptomyces

KW - actinobacteria

KW - diversity

U2 - 10.1021/np400952d

DO - 10.1021/np400952d

M3 - Article

VL - 77

SP - 416

EP - 420

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 2

ER -