@article{9b03400f5c464e6f8e4e0ebe061a5071,
title = "Dermacozines H-J Isolated from a Deep-Sea Strain of Dermacoccus abyssi from Mariana Trench Sediments",
abstract = "Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new Pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H-J (1-3). Extensive use was made of ID and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 mu M.",
keywords = "marine-sediments, challenger deep, streptomyces, actinobacteria, diversity",
author = "Marcell Wagner and Abdel-Mageed, {Wael M.} and Rainer Ebel and Bull, {Alan T.} and Michael Goodfellow and Hans-Peter Fiedler and Marcel Jaspars",
note = "ACKNOWLEDGMENTS The authors are grateful to the Kaiko operation team and the crew of M.S. Yokosuka, JAMSTEC, Yokosuka, Japan, for collecting sediment samples. M.W. thanks the J{\"u}rgen-ManchotFoundation for a generous scholarship and Max-BuchnerForschungsstiftung for support of consumables. M.J. is the recipient of a BBSRC Research Development Fellowship. The authors thank Mr A. Kulik, University of T{\"u}bingen, Germany, for assistance in fermentation and HPLC-ESIMS analysis. The authors are grateful to EPSRC National Mass Spectrometric Centre, University of Wales, Swansea, for mass spectrometric analysis.",
year = "2014",
month = feb,
day = "22",
doi = "10.1021/np400952d",
language = "English",
volume = "77",
pages = "416--420",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "2",
}
