Dietary patterns may influence disease risk via effects on chronic low grade systemic inflammation (CLSI). We examined the relationship between dietary patterns and biomarkers of CLSI in Scottish postmenopausal women. Diet was assessed by validated food frequency questionnaire (FFQ) (n = 3238) during study visits in 1998–2000, when the mean age [SD] of subjects was 55  years. Dietary patterns were generated by principal components analysis (1). In a recent follow up visit after 11.3 [1.3] years, fasted blood was collected (n = 2039, n = 1788 with FFQ data). Serum samples were prepared for analysis of CLSI biomarkers (high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), soluble E selectin (sE selectin), serum amyloid A (SAA)) using standardised immunoassay procedures. ANOVA was used to test the relationship between dietary pattern scores and CLSI biomarker concentrations in a prospective analysis with ANCOVA to control for lifestyle covariates. Five dietary patterns accounted for 26 % of the variance in the diet (1). Women in the highest quintile of the 'healthy' dietary pattern (rich in fruit, vegetables, lean meat and with low scores for sweet foods) had lower median serum concentrations of hsCRP and IL-6, compared to those in the lowest quintile (Table). These relationships remained significant after adjustment for confounders. Concentrations of hsCRP increased with increasing quintiles of the high fat/white fish dietary pattern; and the dietary pattern with positive factor loadings for bread and butter and negative factor loadings for red meat and alcohol was associated with hsCRP and SAA. These relationships were no longer significant after adjustment for confounding covariates.
Dietary patterns are associated with biomarkers of chronic low grade systemic inflammation in Scottish postmenopausal women: a prospective analysis.