Dietary patterns are associated with biomarkers of chronic low grade systemic inflammation in Scottish postmenopausal women: a prospective analysis

Adrian David Wood, William Simpson, Anna A Gryka, Antonia C Hardcastle, Alexandra Mavroeidi, Ian Rothnie, Nicholas James Vaughan, Lorna Sharman Aucott, Garry Graeme Duthie, Frank Thies, Helen Macdonald

Research output: Contribution to journalAbstract

Abstract

Dietary patterns may influence disease risk via effects on chronic low grade systemic inflammation (CLSI). We examined the relationship between dietary patterns and biomarkers of CLSI in Scottish postmenopausal women. Diet was assessed by validated food frequency questionnaire (FFQ) (n = 3238) during study visits in 1998–2000, when the mean age [SD] of subjects was 55 [2] years. Dietary patterns were generated by principal components analysis (1). In a recent follow up visit after 11.3 [1.3] years, fasted blood was collected (n = 2039, n = 1788 with FFQ data). Serum samples were prepared for analysis of CLSI biomarkers (high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), soluble E selectin (sE selectin), serum amyloid A (SAA)) using standardised immunoassay procedures. ANOVA was used to test the relationship between dietary pattern scores and CLSI biomarker concentrations in a prospective analysis with ANCOVA to control for lifestyle covariates. Five dietary patterns accounted for 26 % of the variance in the diet (1). Women in the highest quintile of the 'healthy' dietary pattern (rich in fruit, vegetables, lean meat and with low scores for sweet foods) had lower median serum concentrations of hsCRP and IL-6, compared to those in the lowest quintile (Table). These relationships remained significant after adjustment for confounders. Concentrations of hsCRP increased with increasing quintiles of the high fat/white fish dietary pattern; and the dietary pattern with positive factor loadings for bread and butter and negative factor loadings for red meat and alcohol was associated with hsCRP and SAA. These relationships were no longer significant after adjustment for confounding covariates.

Dietary patterns are associated with biomarkers of chronic low grade systemic inflammation in Scottish postmenopausal women: a prospective analysis.
Original languageEnglish
Pages (from-to)E251
Number of pages1
JournalProceedings of the Nutrition Society
Volume71
DOIs
Publication statusPublished - Jan 2012

Fingerprint

Biomarkers
C-Reactive Protein
Inflammation
Serum Amyloid A Protein
Food
Interleukin-6
Diet
White Adipose Tissue
E-Selectin
Principal Component Analysis
Serum
Immunoassay
Vegetables
Meat
Life Style
Fruit
Analysis of Variance
Fishes
Alcohols
Surveys and Questionnaires

Cite this

Dietary patterns are associated with biomarkers of chronic low grade systemic inflammation in Scottish postmenopausal women: a prospective analysis. / Wood, Adrian David; Simpson, William; Gryka, Anna A; Hardcastle, Antonia C; Mavroeidi, Alexandra; Rothnie, Ian; Vaughan, Nicholas James; Aucott, Lorna Sharman; Duthie, Garry Graeme; Thies, Frank; Macdonald, Helen.

In: Proceedings of the Nutrition Society, Vol. 71, 01.2012, p. E251.

Research output: Contribution to journalAbstract

@article{272acd24f4974fc49e48a7ccc1fd4f95,
title = "Dietary patterns are associated with biomarkers of chronic low grade systemic inflammation in Scottish postmenopausal women: a prospective analysis",
abstract = "Dietary patterns may influence disease risk via effects on chronic low grade systemic inflammation (CLSI). We examined the relationship between dietary patterns and biomarkers of CLSI in Scottish postmenopausal women. Diet was assessed by validated food frequency questionnaire (FFQ) (n = 3238) during study visits in 1998–2000, when the mean age [SD] of subjects was 55 [2] years. Dietary patterns were generated by principal components analysis (1). In a recent follow up visit after 11.3 [1.3] years, fasted blood was collected (n = 2039, n = 1788 with FFQ data). Serum samples were prepared for analysis of CLSI biomarkers (high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), soluble E selectin (sE selectin), serum amyloid A (SAA)) using standardised immunoassay procedures. ANOVA was used to test the relationship between dietary pattern scores and CLSI biomarker concentrations in a prospective analysis with ANCOVA to control for lifestyle covariates. Five dietary patterns accounted for 26 {\%} of the variance in the diet (1). Women in the highest quintile of the 'healthy' dietary pattern (rich in fruit, vegetables, lean meat and with low scores for sweet foods) had lower median serum concentrations of hsCRP and IL-6, compared to those in the lowest quintile (Table). These relationships remained significant after adjustment for confounders. Concentrations of hsCRP increased with increasing quintiles of the high fat/white fish dietary pattern; and the dietary pattern with positive factor loadings for bread and butter and negative factor loadings for red meat and alcohol was associated with hsCRP and SAA. These relationships were no longer significant after adjustment for confounding covariates. Dietary patterns are associated with biomarkers of chronic low grade systemic inflammation in Scottish postmenopausal women: a prospective analysis.",
author = "Wood, {Adrian David} and William Simpson and Gryka, {Anna A} and Hardcastle, {Antonia C} and Alexandra Mavroeidi and Ian Rothnie and Vaughan, {Nicholas James} and Aucott, {Lorna Sharman} and Duthie, {Garry Graeme} and Frank Thies and Helen Macdonald",
year = "2012",
month = "1",
doi = "10.1017/S0029665112003424",
language = "English",
volume = "71",
pages = "E251",
journal = "Proceedings of the Nutrition Society",
issn = "0029-6651",
publisher = "Cambridge Univ. Press.",

}

TY - JOUR

T1 - Dietary patterns are associated with biomarkers of chronic low grade systemic inflammation in Scottish postmenopausal women: a prospective analysis

AU - Wood, Adrian David

AU - Simpson, William

AU - Gryka, Anna A

AU - Hardcastle, Antonia C

AU - Mavroeidi, Alexandra

AU - Rothnie, Ian

AU - Vaughan, Nicholas James

AU - Aucott, Lorna Sharman

AU - Duthie, Garry Graeme

AU - Thies, Frank

AU - Macdonald, Helen

PY - 2012/1

Y1 - 2012/1

N2 - Dietary patterns may influence disease risk via effects on chronic low grade systemic inflammation (CLSI). We examined the relationship between dietary patterns and biomarkers of CLSI in Scottish postmenopausal women. Diet was assessed by validated food frequency questionnaire (FFQ) (n = 3238) during study visits in 1998–2000, when the mean age [SD] of subjects was 55 [2] years. Dietary patterns were generated by principal components analysis (1). In a recent follow up visit after 11.3 [1.3] years, fasted blood was collected (n = 2039, n = 1788 with FFQ data). Serum samples were prepared for analysis of CLSI biomarkers (high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), soluble E selectin (sE selectin), serum amyloid A (SAA)) using standardised immunoassay procedures. ANOVA was used to test the relationship between dietary pattern scores and CLSI biomarker concentrations in a prospective analysis with ANCOVA to control for lifestyle covariates. Five dietary patterns accounted for 26 % of the variance in the diet (1). Women in the highest quintile of the 'healthy' dietary pattern (rich in fruit, vegetables, lean meat and with low scores for sweet foods) had lower median serum concentrations of hsCRP and IL-6, compared to those in the lowest quintile (Table). These relationships remained significant after adjustment for confounders. Concentrations of hsCRP increased with increasing quintiles of the high fat/white fish dietary pattern; and the dietary pattern with positive factor loadings for bread and butter and negative factor loadings for red meat and alcohol was associated with hsCRP and SAA. These relationships were no longer significant after adjustment for confounding covariates. Dietary patterns are associated with biomarkers of chronic low grade systemic inflammation in Scottish postmenopausal women: a prospective analysis.

AB - Dietary patterns may influence disease risk via effects on chronic low grade systemic inflammation (CLSI). We examined the relationship between dietary patterns and biomarkers of CLSI in Scottish postmenopausal women. Diet was assessed by validated food frequency questionnaire (FFQ) (n = 3238) during study visits in 1998–2000, when the mean age [SD] of subjects was 55 [2] years. Dietary patterns were generated by principal components analysis (1). In a recent follow up visit after 11.3 [1.3] years, fasted blood was collected (n = 2039, n = 1788 with FFQ data). Serum samples were prepared for analysis of CLSI biomarkers (high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), soluble E selectin (sE selectin), serum amyloid A (SAA)) using standardised immunoassay procedures. ANOVA was used to test the relationship between dietary pattern scores and CLSI biomarker concentrations in a prospective analysis with ANCOVA to control for lifestyle covariates. Five dietary patterns accounted for 26 % of the variance in the diet (1). Women in the highest quintile of the 'healthy' dietary pattern (rich in fruit, vegetables, lean meat and with low scores for sweet foods) had lower median serum concentrations of hsCRP and IL-6, compared to those in the lowest quintile (Table). These relationships remained significant after adjustment for confounders. Concentrations of hsCRP increased with increasing quintiles of the high fat/white fish dietary pattern; and the dietary pattern with positive factor loadings for bread and butter and negative factor loadings for red meat and alcohol was associated with hsCRP and SAA. These relationships were no longer significant after adjustment for confounding covariates. Dietary patterns are associated with biomarkers of chronic low grade systemic inflammation in Scottish postmenopausal women: a prospective analysis.

U2 - 10.1017/S0029665112003424

DO - 10.1017/S0029665112003424

M3 - Abstract

VL - 71

SP - E251

JO - Proceedings of the Nutrition Society

JF - Proceedings of the Nutrition Society

SN - 0029-6651

ER -