Diversity of organic structures of marine microbial origin with drug potential

Marcel Jaspars*, Rainer Peter Ebel, Hai Deng

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The investigation of marine microorganisms from a range of different marine habitats is likely to be a productive approach to the discovery of novel chemical entities with potent and selective biological activity. Varied habitats to explore include, but are not limited to, marine invertebrates, marine sediments, sub seafloor, hot vents, cryogenic environments and cold seeps. Salinosporamide A is an orally active proteasome inhibitor that induces apoptosis in multiple myeloma cells. Diazepinomicin is a unique farnesylated dibenzodiazepinone produced by a sponge-associated Micromonospora strain. Lomaiviticin A was first isolated from the marine-derived actinomycete Micromonospora lomaivitiensis, a microbial symbiont from the marine ascidian Polysyncraton lithostrotum. Abyssomicin C is a novel polycyclic polyketide antibiotic produced by a marine Verrucosispora strain. Marine chemical diversity does not overlap to any great extent with terrestrially-derived chemical diversity, thus making it an important source of new structures for drug discovery
Original languageEnglish
Title of host publicationPhycotoxins
Subtitle of host publicationChemistry and Biochemistry
EditorsLM Botana, A Alfonso
PublisherBlackwell Science
Pages361-380
Number of pages20
Edition2
ISBN (Print)978-1-118-50036-1
Publication statusPublished - 2015

Keywords

  • VASCULAR-DISRUPTING AGENT
  • FUNGUS PHOMA SP
  • ACTIVATING-FACTOR ANTAGONISTS
  • MULTIPLE-MYELOMA CELLS
  • SPONGE-DERIVED FUNGUS
  • NATURAL-PRODUCTS
  • ANTITUMOR-ACTIVITY
  • SECONDARY METABOLITES
  • ASPERGILLUS-FUMIGATUS
  • PROTEASOME INHIBITOR

Cite this

Jaspars, M., Ebel, R. P., & Deng, H. (2015). Diversity of organic structures of marine microbial origin with drug potential. In LM. Botana, & A. Alfonso (Eds.), Phycotoxins: Chemistry and Biochemistry (2 ed., pp. 361-380). Blackwell Science.

Diversity of organic structures of marine microbial origin with drug potential. / Jaspars, Marcel; Ebel, Rainer Peter; Deng, Hai.

Phycotoxins: Chemistry and Biochemistry. ed. / LM Botana; A Alfonso. 2. ed. Blackwell Science, 2015. p. 361-380.

Research output: Chapter in Book/Report/Conference proceedingChapter

Jaspars, M, Ebel, RP & Deng, H 2015, Diversity of organic structures of marine microbial origin with drug potential. in LM Botana & A Alfonso (eds), Phycotoxins: Chemistry and Biochemistry. 2 edn, Blackwell Science, pp. 361-380.
Jaspars M, Ebel RP, Deng H. Diversity of organic structures of marine microbial origin with drug potential. In Botana LM, Alfonso A, editors, Phycotoxins: Chemistry and Biochemistry. 2 ed. Blackwell Science. 2015. p. 361-380
Jaspars, Marcel ; Ebel, Rainer Peter ; Deng, Hai. / Diversity of organic structures of marine microbial origin with drug potential. Phycotoxins: Chemistry and Biochemistry. editor / LM Botana ; A Alfonso. 2. ed. Blackwell Science, 2015. pp. 361-380
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AB - The investigation of marine microorganisms from a range of different marine habitats is likely to be a productive approach to the discovery of novel chemical entities with potent and selective biological activity. Varied habitats to explore include, but are not limited to, marine invertebrates, marine sediments, sub seafloor, hot vents, cryogenic environments and cold seeps. Salinosporamide A is an orally active proteasome inhibitor that induces apoptosis in multiple myeloma cells. Diazepinomicin is a unique farnesylated dibenzodiazepinone produced by a sponge-associated Micromonospora strain. Lomaiviticin A was first isolated from the marine-derived actinomycete Micromonospora lomaivitiensis, a microbial symbiont from the marine ascidian Polysyncraton lithostrotum. Abyssomicin C is a novel polycyclic polyketide antibiotic produced by a marine Verrucosispora strain. Marine chemical diversity does not overlap to any great extent with terrestrially-derived chemical diversity, thus making it an important source of new structures for drug discovery

KW - VASCULAR-DISRUPTING AGENT

KW - FUNGUS PHOMA SP

KW - ACTIVATING-FACTOR ANTAGONISTS

KW - MULTIPLE-MYELOMA CELLS

KW - SPONGE-DERIVED FUNGUS

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KW - SECONDARY METABOLITES

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KW - PROTEASOME INHIBITOR

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