Does grazing on biosolids treated pasture pose a pathophysiological risk associated with increased exposure to endocrine disrupting compounds?

N P Evans, M Bellingham, R M Sharpe, C Cotinot, S M Rhind, C Kyle, H Erhard, S Hombach-Klonisch, P M Lind, P A Fowler

Research output: Contribution to journalLiterature review

10 Citations (Scopus)

Abstract

Biosolids (processed human sewage sludge), which contain low individual concentrations of an array of contaminants including heavy metals and organic pollutants such as polyaromatic hydrocarbons (PAH), polychlorinated biphenols (PCB) and polychlorinated dibenzodioxins (PCDD)/polychlorinated dibenzofurans (PCDF) known to cause physiological disturbances, is increasingly being used as an agricultural fertilizer. This could pose a health threat to both humans domestic and wild animal species. This review summarizes results of a unique model, used to determine the effects of exposure to mixtures of environmentally relevant concentrations of pollutants, in sheep grazed on biosolids-treated pastures. Pasture treatment results in non-significant increases in environmental chemical (EC) concentrations in soil. Whereas EC concentrations were increased in some tissues of both ewes and their fetuses, concentrations were low, variable and deemed to pose little risk to consumer health. Investigation of the effects of gestational EC exposure on fetal development has highlighted a number of issues. The results indicate that gestational EC exposure can adversely affect gonadal development (males and females) and that these effects can impact testicular morphology, ovarian follicle numbers and health, and the transcriptome and proteome in adult animals. In addition, EC exposure can be associated with altered expression of GnRH, GnRH receptors, galanin receptors and kisspeptin mRNA within the hypothalamus and pituitary gland, gonadotroph populations within the pituitary gland, and regional aberrations in thyroid morphology. In most cases, these anatomical and functional differences do not result in altered peripheral hormone concentrations or reproductive function (e.g., lambing rate), indicating physiological compensation under the conditions tested. Physiological compensation is also suggested from studies that indicate that EC effects may be greater when exposure occurs either before or during gestation, compared with EC exposure throughout life. With regard to human and animal health, this body of work questions the concept of safe individual concentration of EC when EC exposure typically occurs as complex mixtures. It suggests that developmental EC exposure may affect many different physiological systems, with some sex-specific differences in EC sensitivity and that EC effects may be masked under favourable physiological conditions:

Original languageEnglish
Pages (from-to)3185-3198
Number of pages14
JournalJournal of Animal Science
Volume92
Issue number8
Early online date19 Jun 2014
DOIs
Publication statusPublished - Aug 2014

Fingerprint

chemical concentration
endocrine-disrupting chemicals
biosolids
pituitary gland
Environmental Exposure
pollutants
pastures
grazing
polychlorinated dibenzofurans
lambing rate
polychlorinated dibenzodioxins
receptors
animal and human health
ovarian follicles
fetal development
sewage sludge
wild animals
hypothalamus
proteome
domestic animals

Keywords

  • biosolids
  • endocrine disruption
  • reproduction
  • sheep

Cite this

Does grazing on biosolids treated pasture pose a pathophysiological risk associated with increased exposure to endocrine disrupting compounds? / Evans, N P; Bellingham, M; Sharpe, R M; Cotinot, C; Rhind, S M; Kyle, C; Erhard, H; Hombach-Klonisch, S; Lind, P M; Fowler, P A.

In: Journal of Animal Science, Vol. 92, No. 8, 08.2014, p. 3185-3198.

Research output: Contribution to journalLiterature review

Evans, NP, Bellingham, M, Sharpe, RM, Cotinot, C, Rhind, SM, Kyle, C, Erhard, H, Hombach-Klonisch, S, Lind, PM & Fowler, PA 2014, 'Does grazing on biosolids treated pasture pose a pathophysiological risk associated with increased exposure to endocrine disrupting compounds?', Journal of Animal Science, vol. 92, no. 8, pp. 3185-3198. https://doi.org/10.2527/jas.2014-7763
Evans, N P ; Bellingham, M ; Sharpe, R M ; Cotinot, C ; Rhind, S M ; Kyle, C ; Erhard, H ; Hombach-Klonisch, S ; Lind, P M ; Fowler, P A. / Does grazing on biosolids treated pasture pose a pathophysiological risk associated with increased exposure to endocrine disrupting compounds?. In: Journal of Animal Science. 2014 ; Vol. 92, No. 8. pp. 3185-3198.
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AU - Rhind, S M

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