Donor safety in live donor laparoscopic liver procurement

systematic review and meta-analysis

Mohamed Bekheit*, Philipe Abrahim Khafagy, Petru Bucur, Khaled Katri, Ahmed Elgendi, Wael Nabil Abdel-salam, Eric Vibert, El Said El-kayal

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Donor safety is a major concern in live organ donation. Live donor laparoscopic liver procurement is an advanced surgical procedure that is performed in highly specialized centers. Since its first report, not much progress has been endeavored for that procedure. Methods: We planned to include all the randomized and comparative nonrandomized studies. Patients’ population: live donors who are submitted to organ procurement via laparoscopy. Results: Out of 5,636 records retrieved from the literature, only seven nonrandomized studies were included in this review, which encompassed 418 patients, 151 patients of whom underwent laparoscopic procurement. The quality scores for the included studies ranged from 66 to 76 %. The operative time was significantly shorter in the conventional open group (SD = 0.863, 95 % CI 0.107–1.819). Blood loss in the laparoscopic group was comparable with the conventional open approach (SD = −0.307, 95 % CI −0.807 to 0.192). In subgroup analysis, laparoscopy was protective against blood loss in laparoscopic parenchymal dissection (SD = −1.168, 95 % CI −1.758 to −0.577). The hospital stay was equal in both groups. Patients in laparoscopic group consumed fewer analgesics compared with conventional open group (SD = −0.33, 95 % CI −0.63 to −0.03). Analgesics use was lower in the laparoscopic group compared with the conventional approach. The rate of Clavien complications was equal in both groups (OR 0.721, 95 % CI 0.303–1.716). No difference was found between subgroup analysis based on the harvested liver lobe. Funnel plot and statistical methods used revealed low probability of publication BIAS. Conclusions: Live donor laparoscopic liver procurement could be as safe as the conventional open approach. Lower blood loss and lower consumtion of analgesics might be offered in the laparoscopic approach.

Original languageEnglish
Pages (from-to)3047-3064
Number of pages18
JournalSurgical Endoscopy
Volume29
Issue number11
Early online date1 Jan 2015
DOIs
Publication statusPublished - 1 Nov 2015

Fingerprint

Meta-Analysis
Tissue Donors
Analgesics
Safety
Tissue and Organ Procurement
Liver
Laparoscopy
Operative Time
Publications
Dissection
Length of Stay
Population

Keywords

  • Abdominal
  • Digestive
  • Hepatobiliare (liver)
  • Laparoscopic
  • Live donor
  • Liver transplantation
  • Surgical
  • Transplantation

ASJC Scopus subject areas

  • Surgery

Cite this

Bekheit, M., Khafagy, P. A., Bucur, P., Katri, K., Elgendi, A., Abdel-salam, W. N., ... El-kayal, E. S. (2015). Donor safety in live donor laparoscopic liver procurement: systematic review and meta-analysis. Surgical Endoscopy, 29(11), 3047-3064. https://doi.org/10.1007/s00464-014-4045-1

Donor safety in live donor laparoscopic liver procurement : systematic review and meta-analysis. / Bekheit, Mohamed; Khafagy, Philipe Abrahim; Bucur, Petru; Katri, Khaled; Elgendi, Ahmed; Abdel-salam, Wael Nabil; Vibert, Eric; El-kayal, El Said.

In: Surgical Endoscopy, Vol. 29, No. 11, 01.11.2015, p. 3047-3064.

Research output: Contribution to journalArticle

Bekheit, M, Khafagy, PA, Bucur, P, Katri, K, Elgendi, A, Abdel-salam, WN, Vibert, E & El-kayal, ES 2015, 'Donor safety in live donor laparoscopic liver procurement: systematic review and meta-analysis', Surgical Endoscopy, vol. 29, no. 11, pp. 3047-3064. https://doi.org/10.1007/s00464-014-4045-1
Bekheit, Mohamed ; Khafagy, Philipe Abrahim ; Bucur, Petru ; Katri, Khaled ; Elgendi, Ahmed ; Abdel-salam, Wael Nabil ; Vibert, Eric ; El-kayal, El Said. / Donor safety in live donor laparoscopic liver procurement : systematic review and meta-analysis. In: Surgical Endoscopy. 2015 ; Vol. 29, No. 11. pp. 3047-3064.
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abstract = "Background: Donor safety is a major concern in live organ donation. Live donor laparoscopic liver procurement is an advanced surgical procedure that is performed in highly specialized centers. Since its first report, not much progress has been endeavored for that procedure. Methods: We planned to include all the randomized and comparative nonrandomized studies. Patients’ population: live donors who are submitted to organ procurement via laparoscopy. Results: Out of 5,636 records retrieved from the literature, only seven nonrandomized studies were included in this review, which encompassed 418 patients, 151 patients of whom underwent laparoscopic procurement. The quality scores for the included studies ranged from 66 to 76 {\%}. The operative time was significantly shorter in the conventional open group (SD = 0.863, 95 {\%} CI 0.107–1.819). Blood loss in the laparoscopic group was comparable with the conventional open approach (SD = −0.307, 95 {\%} CI −0.807 to 0.192). In subgroup analysis, laparoscopy was protective against blood loss in laparoscopic parenchymal dissection (SD = −1.168, 95 {\%} CI −1.758 to −0.577). The hospital stay was equal in both groups. Patients in laparoscopic group consumed fewer analgesics compared with conventional open group (SD = −0.33, 95 {\%} CI −0.63 to −0.03). Analgesics use was lower in the laparoscopic group compared with the conventional approach. The rate of Clavien complications was equal in both groups (OR 0.721, 95 {\%} CI 0.303–1.716). No difference was found between subgroup analysis based on the harvested liver lobe. Funnel plot and statistical methods used revealed low probability of publication BIAS. Conclusions: Live donor laparoscopic liver procurement could be as safe as the conventional open approach. Lower blood loss and lower consumtion of analgesics might be offered in the laparoscopic approach.",
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AU - Elgendi, Ahmed

AU - Abdel-salam, Wael Nabil

AU - Vibert, Eric

AU - El-kayal, El Said

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