Dopamine Transporter and Reward Anticipation in a Dimensional Perspective

A Multimodal Brain Imaging Study

Manon Dubol, Christian Trichard, Claire Leroy, Anca-Larisa Sandu-Giuraniuc, Mehdi Rahim, Bernard Granger, Eleni T Tzavara, Laurent Karila, Jean-Luc Martinot, Eric Artiges

Research output: Contribution to journalArticle

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Abstract

Dopamine function and reward processing are highly interrelated and involve common brain regions afferent to the nucleus accumbens, within the mesolimbic pathway. Although dopamine function and reward system neural activity are impaired in most psychiatric disorders, it is unknown whether alterations in the dopamine system underlie variations in reward processing across a continuum encompassing health and these disorders. We explored the relationship between dopamine function and neural activity during reward anticipation in 27 participants including healthy volunteers and psychiatric patients with schizophrenia, depression, or cocaine addiction, using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) multimodal imaging with a voxel-based statistical approach. Dopamine transporter (DAT) availability was assessed with PET and [11C]PE2I as a marker of presynaptic dopamine function, and reward-related neural response was assessed using fMRI with a modified Monetary Incentive Delay task. Across all the participants, DAT availability in the midbrain correlated positively with the neural response to anticipation of reward in the nucleus accumbens. Moreover, this relationship was conserved in each clinical subgroup, despite the heterogeneity of mental illnesses examined. For the first time, a direct link between DAT availability and reward anticipation was detected within the mesolimbic pathway in healthy and psychiatric participants, and suggests that dopaminergic dysfunction is a common mechanism underlying the alterations of reward processing observed in patients across diagnostic categories. The findings support the use of a dimensional approach in psychiatry, as promoted by the Research Domain Criteria project to identify neurobiological signatures of core dysfunctions underling mental illnesses.
Original languageEnglish
Pages (from-to)820-827
Number of pages8
JournalNeuropsychopharmacology
Volume43
Early online date22 Aug 2017
DOIs
Publication statusPublished - 2018

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Multimodal Imaging
Dopamine Plasma Membrane Transport Proteins
Reward
Neuroimaging
Dopamine
Psychiatry
Nucleus Accumbens
Positron-Emission Tomography
Healthy Volunteers
Magnetic Resonance Imaging
Cocaine-Related Disorders
Mesencephalon
Motivation
Schizophrenia
Depression

Keywords

  • psychiatric disorders
  • reward
  • transporters in the nervous system

Cite this

Dopamine Transporter and Reward Anticipation in a Dimensional Perspective : A Multimodal Brain Imaging Study. / Dubol, Manon; Trichard, Christian ; Leroy, Claire; Sandu-Giuraniuc, Anca-Larisa; Rahim, Mehdi; Granger, Bernard; Tzavara, Eleni T; Karila, Laurent; Martinot, Jean-Luc; Artiges, Eric.

In: Neuropsychopharmacology, Vol. 43, 2018, p. 820-827.

Research output: Contribution to journalArticle

Dubol, M, Trichard, C, Leroy, C, Sandu-Giuraniuc, A-L, Rahim, M, Granger, B, Tzavara, ET, Karila, L, Martinot, J-L & Artiges, E 2018, 'Dopamine Transporter and Reward Anticipation in a Dimensional Perspective: A Multimodal Brain Imaging Study', Neuropsychopharmacology, vol. 43, pp. 820-827. https://doi.org/10.1038/npp.2017.183
Dubol, Manon ; Trichard, Christian ; Leroy, Claire ; Sandu-Giuraniuc, Anca-Larisa ; Rahim, Mehdi ; Granger, Bernard ; Tzavara, Eleni T ; Karila, Laurent ; Martinot, Jean-Luc ; Artiges, Eric. / Dopamine Transporter and Reward Anticipation in a Dimensional Perspective : A Multimodal Brain Imaging Study. In: Neuropsychopharmacology. 2018 ; Vol. 43. pp. 820-827.
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abstract = "Dopamine function and reward processing are highly interrelated and involve common brain regions afferent to the nucleus accumbens, within the mesolimbic pathway. Although dopamine function and reward system neural activity are impaired in most psychiatric disorders, it is unknown whether alterations in the dopamine system underlie variations in reward processing across a continuum encompassing health and these disorders. We explored the relationship between dopamine function and neural activity during reward anticipation in 27 participants including healthy volunteers and psychiatric patients with schizophrenia, depression, or cocaine addiction, using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) multimodal imaging with a voxel-based statistical approach. Dopamine transporter (DAT) availability was assessed with PET and [11C]PE2I as a marker of presynaptic dopamine function, and reward-related neural response was assessed using fMRI with a modified Monetary Incentive Delay task. Across all the participants, DAT availability in the midbrain correlated positively with the neural response to anticipation of reward in the nucleus accumbens. Moreover, this relationship was conserved in each clinical subgroup, despite the heterogeneity of mental illnesses examined. For the first time, a direct link between DAT availability and reward anticipation was detected within the mesolimbic pathway in healthy and psychiatric participants, and suggests that dopaminergic dysfunction is a common mechanism underlying the alterations of reward processing observed in patients across diagnostic categories. The findings support the use of a dimensional approach in psychiatry, as promoted by the Research Domain Criteria project to identify neurobiological signatures of core dysfunctions underling mental illnesses.",
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AU - Granger, Bernard

AU - Tzavara, Eleni T

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