Dynamic changes in network synchrony reveal resting-state functional networks

Vesna Vuksanovic, Philipp Hövel

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Experimental functional magnetic resonance imaging studies have shown that spontaneous brain activity, i.e., in the absence of any external input, exhibit complex spatial and temporal patterns of co-activity between segregated brain regions. These so-called large-scale resting-state functional connectivity networks represent dynamically organized neural assemblies interacting with each other in a complex way. It has been suggested that looking at the dynamical properties of complex patterns of brain functional co-activity may reveal neural mechanisms underlying the dynamic changes in functional interactions. Here, we examine how global network dynamics is shaped by different network configurations, derived from realistic brain functional interactions. We focus on two main dynamics measures: synchrony and variations in synchrony. Neural activity and the inferred hemodynamic response of the network nodes are simulated using a system of 90 FitzHugh-Nagumo neural models subject to system noise and time-delayed interactions. These models are embedded into the topology of the complex brain functional interactions, whose architecture is additionally reduced to its main structural pathways. In the simulated functional networks, patterns of correlated regional activity clearly arise from dynamical properties that maximize synchrony and variations in synchrony. Our results on the fast changes of the level of the network synchrony also show how flexible changes in the large-scale network dynamics could be.

Original languageEnglish
Article number023116
Number of pages9
JournalChaos
Volume25
Issue number2
Early online date27 Feb 2015
DOIs
Publication statusPublished - Feb 2015

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Synchrony
Brain
brain
Network Dynamics
Interaction
FitzHugh-Nagumo
Network Connectivity
Functional Magnetic Resonance Imaging
Global Dynamics
Hemodynamics
hemodynamic responses
interactions
Pathway
Maximise
Topology
assemblies
magnetic resonance
Configuration
topology
Vertex of a graph

Keywords

  • Brain functional interactions
  • Neural activity

Cite this

Dynamic changes in network synchrony reveal resting-state functional networks. / Vuksanovic, Vesna; Hövel, Philipp.

In: Chaos, Vol. 25, No. 2, 023116, 02.2015.

Research output: Contribution to journalArticle

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