Dysregulation of the autonomic nervous system and its association with the presence and intensity of chronic widespread pain

Ansam Barakat, Nicole Vogelzangs, Carmilla M.M. Licht, Rinie Geenen, Gary J. MacFarlane, Eco J.C. De Geus, Johannes H. Smit, Brenda W.J.H. Penninx, Joost Dekker*

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective To test the hypotheses that dysregulation of the autonomic nervous system (ANS) is associated with the presence of chronic widespread pain (CWP), and that dysregulation of the ANS is associated with higher pain intensity in CWP. Methods Cross-sectional data were obtained from 1,574 subjects (healthy controls as well as persons with depressive and anxiety disorders) participating in The Netherlands Study of Depression and Anxiety. The Chronic Pain Grade was used to assess pain intensity and pain-related disability. Heart rate (HR), SD of the normal-to-normal interval (SDNN), the preejection period (PEP), and respiratory sinus arrhythmia (RSA) were used to assess the ANS. Logistic regression analyses and linear regression analyses were conducted with adjustment for potential confounders. Results No differences in HR, PEP, SDNN, or RSA values were found between CWP subjects and controls after adjustment for confounders. However, lower SDNN and lower RSA were associated with higher pain intensity in subjects with CWP. Conclusion Lower parasympathetic activity, as assessed with SDNN and RSA, is associated with higher pain intensity in subjects with CWP. This large and well-controlled study does not provide evidence for an association between dysregulation of the ANS and the presence of CWP.

Original languageEnglish
Pages (from-to)1209-1216
Number of pages8
JournalArthritis Care and Research
Volume64
Issue number8
Early online date27 Jul 2012
DOIs
Publication statusPublished - Aug 2012

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Autonomic Nervous System
Chronic Pain
Pain
Heart Rate
Regression Analysis
Depressive Disorder
Anxiety Disorders
Netherlands
Linear Models
Healthy Volunteers
Anxiety
Logistic Models
Depression
Respiratory Sinus Arrhythmia

ASJC Scopus subject areas

  • Rheumatology

Cite this

Dysregulation of the autonomic nervous system and its association with the presence and intensity of chronic widespread pain. / Barakat, Ansam; Vogelzangs, Nicole; Licht, Carmilla M.M.; Geenen, Rinie; MacFarlane, Gary J.; De Geus, Eco J.C.; Smit, Johannes H.; Penninx, Brenda W.J.H.; Dekker, Joost.

In: Arthritis Care and Research, Vol. 64, No. 8, 08.2012, p. 1209-1216.

Research output: Contribution to journalArticle

Barakat, A, Vogelzangs, N, Licht, CMM, Geenen, R, MacFarlane, GJ, De Geus, EJC, Smit, JH, Penninx, BWJH & Dekker, J 2012, 'Dysregulation of the autonomic nervous system and its association with the presence and intensity of chronic widespread pain', Arthritis Care and Research, vol. 64, no. 8, pp. 1209-1216. https://doi.org/10.1002/acr.21669
Barakat, Ansam ; Vogelzangs, Nicole ; Licht, Carmilla M.M. ; Geenen, Rinie ; MacFarlane, Gary J. ; De Geus, Eco J.C. ; Smit, Johannes H. ; Penninx, Brenda W.J.H. ; Dekker, Joost. / Dysregulation of the autonomic nervous system and its association with the presence and intensity of chronic widespread pain. In: Arthritis Care and Research. 2012 ; Vol. 64, No. 8. pp. 1209-1216.
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