Effect of a conjugated linoleic acid and omega-3 fatty acid mixture on body composition and adiponectin

Alan Arthur Sneddon, Fotini Tsofliou, Claire Fyfe, Ian Matheson, Diane Jackson, Graham W Horgan, Maria S. Winzell, Klaus Wilfried Juergen Wahle, Bo Ahren, Lynda Williams

Research output: Contribution to journalArticle

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Abstract

This study aimed to determine the effect of supplementation with conjugated linoleic acids (CLAs) plus n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) on body composition, adiposity, and hormone levels in young and older, lean and obese men. Young (31.4 +/- 3.9 years) lean (BMI, 23.6 +/- 1.5 kg/m(2); n = 13) and obese (BMI, 32.4 +/- 1.9 kg/m(2); n = 12) and older (56.5 +/- 4.6 years) lean (BMI, 23.6 +/- 1.5 kg/m(2); n = 20) and obese (BMI, 32.0 +/- 1.6 kg/m(2); n = 14) men participated in a double-blind placebo-controlled, randomized crossover study. Subjects received either 6 g/day control fat or 3 g/day CLA (50:50 cis-9, trans-11: trans-10, cis-12) and 3 g/day n-3 LC-PUFA for 12 weeks with a 12-week wash-out period between crossovers. Body composition was assessed by dual-energy X-ray absorptiometry. Fasting adiponectin, leptin, glucose, and insulin concentrations were measured and insulin resistance estimated by homeostasis model assessment for insulin resistance (HOMA-IR). In the younger obese subjects, CLA plus n-3 LC-PUFA supplementation compared with control fat did not result in increased abdominal fat and raised both fat-free mass (2.4%) and adiponectin levels (12%). CLA plus n-3 LC-PUFA showed no significant effects on HOMA-IR in any group but did increase fasting glucose in older obese subjects. In summary, supplementation with CLA plus n-3 LC-PUFA prevents increased abdominal fat mass and raises fat-free mass and adiponectin levels in younger obese individuals without deleteriously affecting insulin sensitivity, whereas these parameters in young and older lean and older obese individuals were unaffected, apart from increased fasting glucose in older obese men.

Original languageEnglish
Pages (from-to)1019-1024
Number of pages6
JournalObesity
Volume16
Issue number5
Early online date6 Mar 2008
DOIs
Publication statusPublished - May 2008

Keywords

  • polyunsaturated fatty-acids
  • type-2 diabetes-mellitus
  • insulin-resistance
  • fish-oil
  • adipose-tissue
  • metabolic syndrome
  • glucose-tolerance
  • close association
  • aerobic exercise
  • gene-expression

Cite this

Sneddon, A. A., Tsofliou, F., Fyfe, C., Matheson, I., Jackson, D., Horgan, G. W., ... Williams, L. (2008). Effect of a conjugated linoleic acid and omega-3 fatty acid mixture on body composition and adiponectin. Obesity, 16(5), 1019-1024. https://doi.org/10.1038/oby.2008.41

Effect of a conjugated linoleic acid and omega-3 fatty acid mixture on body composition and adiponectin. / Sneddon, Alan Arthur; Tsofliou, Fotini; Fyfe, Claire; Matheson, Ian; Jackson, Diane; Horgan, Graham W; Winzell, Maria S.; Wahle, Klaus Wilfried Juergen; Ahren, Bo; Williams, Lynda.

In: Obesity, Vol. 16, No. 5, 05.2008, p. 1019-1024.

Research output: Contribution to journalArticle

Sneddon, AA, Tsofliou, F, Fyfe, C, Matheson, I, Jackson, D, Horgan, GW, Winzell, MS, Wahle, KWJ, Ahren, B & Williams, L 2008, 'Effect of a conjugated linoleic acid and omega-3 fatty acid mixture on body composition and adiponectin', Obesity, vol. 16, no. 5, pp. 1019-1024. https://doi.org/10.1038/oby.2008.41
Sneddon, Alan Arthur ; Tsofliou, Fotini ; Fyfe, Claire ; Matheson, Ian ; Jackson, Diane ; Horgan, Graham W ; Winzell, Maria S. ; Wahle, Klaus Wilfried Juergen ; Ahren, Bo ; Williams, Lynda. / Effect of a conjugated linoleic acid and omega-3 fatty acid mixture on body composition and adiponectin. In: Obesity. 2008 ; Vol. 16, No. 5. pp. 1019-1024.
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AU - Jackson, Diane

AU - Horgan, Graham W

AU - Winzell, Maria S.

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AU - Ahren, Bo

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N2 - This study aimed to determine the effect of supplementation with conjugated linoleic acids (CLAs) plus n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) on body composition, adiposity, and hormone levels in young and older, lean and obese men. Young (31.4 +/- 3.9 years) lean (BMI, 23.6 +/- 1.5 kg/m(2); n = 13) and obese (BMI, 32.4 +/- 1.9 kg/m(2); n = 12) and older (56.5 +/- 4.6 years) lean (BMI, 23.6 +/- 1.5 kg/m(2); n = 20) and obese (BMI, 32.0 +/- 1.6 kg/m(2); n = 14) men participated in a double-blind placebo-controlled, randomized crossover study. Subjects received either 6 g/day control fat or 3 g/day CLA (50:50 cis-9, trans-11: trans-10, cis-12) and 3 g/day n-3 LC-PUFA for 12 weeks with a 12-week wash-out period between crossovers. Body composition was assessed by dual-energy X-ray absorptiometry. Fasting adiponectin, leptin, glucose, and insulin concentrations were measured and insulin resistance estimated by homeostasis model assessment for insulin resistance (HOMA-IR). In the younger obese subjects, CLA plus n-3 LC-PUFA supplementation compared with control fat did not result in increased abdominal fat and raised both fat-free mass (2.4%) and adiponectin levels (12%). CLA plus n-3 LC-PUFA showed no significant effects on HOMA-IR in any group but did increase fasting glucose in older obese subjects. In summary, supplementation with CLA plus n-3 LC-PUFA prevents increased abdominal fat mass and raises fat-free mass and adiponectin levels in younger obese individuals without deleteriously affecting insulin sensitivity, whereas these parameters in young and older lean and older obese individuals were unaffected, apart from increased fasting glucose in older obese men.

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KW - adipose-tissue

KW - metabolic syndrome

KW - glucose-tolerance

KW - close association

KW - aerobic exercise

KW - gene-expression

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