Effect of brown seaweed on plasma glucose in healthy, at-risk, and type 2 diabetic individuals: systematic review and meta-analysis

Kate Vaughan, Viren Ranawana, David Cooper, Magaly Aceves-Martins

Research output: Contribution to journalArticlepeer-review

Abstract

Context
Sustained hyperglycemia triggers chronic disease, including type 2 diabetes. A considerable volume of research has explored the effects of brown seaweed on plasma glucose control, but equivocal findings have been reported.
Objective
A systematic review and meta-analysis was conducted to assess the evidence from human randomized controlled trials (RCTs) on the effects of brown seaweed on plasma glucose in healthy, at-risk, and individuals with type 2 diabetes.
Data Sources
MEDLINE/PubMed, EMBASE, and the Cochrane Library were searched for reports published between 2000 and 2020.
Data Extraction
Population, intervention, comparator, outcome, and study design data were extracted.
Data Analysis
Eighteen RCTs met our inclusion criteria. The reported results varied across and between populations. Meta-analyses showed a significant effect, favoring the intervention group for both fasting (mean difference –4.6 [95% CI –7.88, –1.33]) and postprandial (mean difference –7.1 [95% CI –7.4, –6.9]) plasma glucose.
Conclusion
Brown seaweed and its extracts show potential for preventing and managing hyperglycemia. Our meta-analysis confirms that brown seaweed positively affects plasma glucose homeostasis, with particularly promising postprandial plasma glucose effects. However, further research is needed because no high-quality RCT was identified. Species-specific and dose–response research is also required.
Original languageEnglish
Article numbernuab069
Number of pages12
JournalNutrition Reviews
Early online date21 Sep 2021
DOIs
Publication statusE-pub ahead of print - 21 Sep 2021

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