Effect of inspired air conditions on exercise-induced bronchoconstriction and urinary CC16 levels in athletes

C. Bolger, E. Tufvesson, S. D. Anderson, G. Devereux, J. G. Ayres, L. Bjermer, M. Sue-Chu, P. Kippelen

Research output: Contribution to journalArticle

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Abstract

Injury to the airway epithelium has been proposed as a key susceptibility factor for exercise-induced bronchoconstriction (EIB). Our goals were to establish whether airway epithelial cell injury occurs during EIB in athletes and whether inhalation of warm humid air inhibits this injury. Twenty-one young male athletes (10 with a history of EIB) performed two 8-min exercise tests near maximal aerobic capacity in cold dry (4°C, 37% relative humidity) and warm humid (25°C, 94% relative humidity) air on separate days. Postexercise changes in urinary CC16 were used as a biomarker of airway epithelial cell perturbation and injury. Bronchoconstriction occurred in eight athletes in the cold dry environment and was completely blocked by inhalation of warm humid air [maximal fall in forced expiratory volume in 1 s = 18.1 ± 2.1% (SD) in cold dry air and 1.7 ± 0.8% in warm humid air, P <0.01]. Exercise caused an increase in urinary excretion of CC16 in all subjects (P <0.001), but this rise in CC16 was blunted following inhalation of warm humid air [median CC16 increase pre- to postchallenge = 1.91 and 0.35 ng/μmol in cold dry and warm humid air, respectively, in athletes with EIB (P = 0.017) and 1.68 and 0.48 ng/μmol in cold dry and warm humid air, respectively, in athletes without EIB (P = 0.002)]. The results indicate that exercise hyperpnea transiently disrupts the airway epithelium of all athletes (not only in those with EIB) and that inhalation of warm moist air limits airway epithelial cell perturbation and injury.
Original languageEnglish
Pages (from-to)1059-65
Number of pages7
JournalJournal of Applied Physiology
Volume111
Issue number4
Early online date28 Jul 2011
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Bronchoconstriction
Athletes
Air
Exercise
Inhalation
Wounds and Injuries
Epithelial Cells
Humidity
Epithelium
Forced Expiratory Volume
Exercise Test
Biomarkers

Keywords

  • inhalation
  • respiratory mucosa
  • humans
  • humidity
  • air
  • exercise
  • uteroglobin
  • exercise test
  • epithelial cells
  • adult
  • bronchoconstriction
  • cross-over studies
  • air conditioning
  • male
  • athletes

Cite this

Effect of inspired air conditions on exercise-induced bronchoconstriction and urinary CC16 levels in athletes. / Bolger, C.; Tufvesson, E.; Anderson, S. D.; Devereux, G.; Ayres, J. G.; Bjermer, L.; Sue-Chu, M.; Kippelen, P.

In: Journal of Applied Physiology, Vol. 111, No. 4, 10.2011, p. 1059-65.

Research output: Contribution to journalArticle

Bolger, C. ; Tufvesson, E. ; Anderson, S. D. ; Devereux, G. ; Ayres, J. G. ; Bjermer, L. ; Sue-Chu, M. ; Kippelen, P. / Effect of inspired air conditions on exercise-induced bronchoconstriction and urinary CC16 levels in athletes. In: Journal of Applied Physiology. 2011 ; Vol. 111, No. 4. pp. 1059-65.
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AU - Bolger, C.

AU - Tufvesson, E.

AU - Anderson, S. D.

AU - Devereux, G.

AU - Ayres, J. G.

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AU - Sue-Chu, M.

AU - Kippelen, P.

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N2 - Injury to the airway epithelium has been proposed as a key susceptibility factor for exercise-induced bronchoconstriction (EIB). Our goals were to establish whether airway epithelial cell injury occurs during EIB in athletes and whether inhalation of warm humid air inhibits this injury. Twenty-one young male athletes (10 with a history of EIB) performed two 8-min exercise tests near maximal aerobic capacity in cold dry (4°C, 37% relative humidity) and warm humid (25°C, 94% relative humidity) air on separate days. Postexercise changes in urinary CC16 were used as a biomarker of airway epithelial cell perturbation and injury. Bronchoconstriction occurred in eight athletes in the cold dry environment and was completely blocked by inhalation of warm humid air [maximal fall in forced expiratory volume in 1 s = 18.1 ± 2.1% (SD) in cold dry air and 1.7 ± 0.8% in warm humid air, P <0.01]. Exercise caused an increase in urinary excretion of CC16 in all subjects (P <0.001), but this rise in CC16 was blunted following inhalation of warm humid air [median CC16 increase pre- to postchallenge = 1.91 and 0.35 ng/μmol in cold dry and warm humid air, respectively, in athletes with EIB (P = 0.017) and 1.68 and 0.48 ng/μmol in cold dry and warm humid air, respectively, in athletes without EIB (P = 0.002)]. The results indicate that exercise hyperpnea transiently disrupts the airway epithelium of all athletes (not only in those with EIB) and that inhalation of warm moist air limits airway epithelial cell perturbation and injury.

AB - Injury to the airway epithelium has been proposed as a key susceptibility factor for exercise-induced bronchoconstriction (EIB). Our goals were to establish whether airway epithelial cell injury occurs during EIB in athletes and whether inhalation of warm humid air inhibits this injury. Twenty-one young male athletes (10 with a history of EIB) performed two 8-min exercise tests near maximal aerobic capacity in cold dry (4°C, 37% relative humidity) and warm humid (25°C, 94% relative humidity) air on separate days. Postexercise changes in urinary CC16 were used as a biomarker of airway epithelial cell perturbation and injury. Bronchoconstriction occurred in eight athletes in the cold dry environment and was completely blocked by inhalation of warm humid air [maximal fall in forced expiratory volume in 1 s = 18.1 ± 2.1% (SD) in cold dry air and 1.7 ± 0.8% in warm humid air, P <0.01]. Exercise caused an increase in urinary excretion of CC16 in all subjects (P <0.001), but this rise in CC16 was blunted following inhalation of warm humid air [median CC16 increase pre- to postchallenge = 1.91 and 0.35 ng/μmol in cold dry and warm humid air, respectively, in athletes with EIB (P = 0.017) and 1.68 and 0.48 ng/μmol in cold dry and warm humid air, respectively, in athletes without EIB (P = 0.002)]. The results indicate that exercise hyperpnea transiently disrupts the airway epithelium of all athletes (not only in those with EIB) and that inhalation of warm moist air limits airway epithelial cell perturbation and injury.

KW - inhalation

KW - respiratory mucosa

KW - humans

KW - humidity

KW - air

KW - exercise

KW - uteroglobin

KW - exercise test

KW - epithelial cells

KW - adult

KW - bronchoconstriction

KW - cross-over studies

KW - air conditioning

KW - male

KW - athletes

U2 - 10.1152/japplphysiol.00113.2011

DO - 10.1152/japplphysiol.00113.2011

M3 - Article

C2 - 21799131

VL - 111

SP - 1059

EP - 1065

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 4

ER -