Effect of vitamin K2 on postural sway in older people who fall: a randomised controlled trial

Miles D. Witham; Rosemary J. G. Price; Margaret M. Band; Michael S. Hannah; Roberta L. Fulton; Clare L. Clarke; Peter T. Donnan; Paul McNamee; Vera Cvoro; Roy L. Soiza

doi:10.1111/jgs.16024

Effect of vitamin K2 on postural sway in older people who fall: a randomised controlled trial

Miles D. Witham^* (Corresponding Author), Rosemary J. G. Price, Margaret M. Band, Michael S. Hannah, Roberta L. Fulton, Clare L. Clarke, Peter T. Donnan, Paul McNamee, Vera Cvoro, Roy L. Soiza

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

6 Downloads (Pure)

Abstract

OBJECTIVES: Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people at risk of falls. DESIGN: Parallel‐group double‐blind randomized placebo‐controlled trial. SETTING: Fourteen primary care practices in Scotland, UK. PARTICIPANTS: A total of 95 community‐dwelling participants aged 65 and older with at least two falls, or one injurious fall, in the previous year. INTERVENTION: Once/day placebo, 200 μg or 400 μg of oral vitamin K2 for 1 year. MEASUREMENTS: The primary outcome was anteroposterior sway measured using sway plates at 12 months, adjusted for baseline. Secondary outcomes included the Short Physical Performance Battery, Berg Balance Scale, Timed Up & Go Test, quality of life, health and social care costs, falls, and adverse events. RESULTS: Mean participant age was 75 (standard deviation [SD] = 7) years. Overall, 58 of 95 (61%) were female; 77 of 95 (81%) attended the 12‐month visit. No significant effect of either vitamin K2 dose was seen on the primary outcome of anteroposterior sway (200 μg vs placebo: −.19 cm [95% confidence interval [CI] −.68 to .30; P = .44]; 400 μg vs placebo: .17 cm [95% CI −.33 to .66; P = .50]; or 400 μg vs 200 μg: .36 cm [95% CI −.11 to .83; P = .14]). Adjusted falls rates were similar in each group. No significant treatment effects were seen for other measures of sway or secondary outcomes. Costs were higher in both vitamin K2 arms than in the placebo arm. CONCLUSION: Oral vitamin K2 supplementation did not improve postural sway or physical function in older people at risk of falls. Trial registration: ISRCTN18436190

Original language	English
Pages (from-to)	2102-2107
Number of pages	6
Journal	Journal of the American Geriatrics Society
Volume	67
Issue number	10
Early online date	18 Jun 2019
DOIs	https://doi.org/10.1111/jgs.16024
Publication status	Published - Oct 2019
Event	British Geriatrics Society Spring Scientific Meeting 2019 - Cardiff, United Kingdom Duration: 10 Apr 2019 → 10 Apr 2019

Bibliographical note

Funding

This work was supported by the Chief Scientist Office, Scottish Government, grant number CZH/4/1100

Acknowledgements

With thanks to NHS Support for Science for supporting the trial; the participants for agreeing to take part, and NHS Research Scotland Primary Care Network for their help recruiting participants. We thank Petra Rauchhaus for statistical advice during preparation of the statistical analysis plan for this trial, and Tayside Clinical Trials Unit for their assistance with the management of the trial. The design, results analysis and manuscript drafting were all performed independently with no input from the Sponsor (Tayside Academic Sciences Centre; a joint enterprise between University of Dundee and NHS Tayside). The full protocol, statistical and health economic analysis plans are available from the corresponding author on request.

Professor Witham acknowledges support from the NIHR Newcastle Biomedical Research Centre

Keywords

falls
vitamin K
postural sway
health economic analysis
recruitment
PREVENTION
RISK
K SUPPLEMENTATION
BALANCE
WOMEN
COMMUNITY
PREDICTORS
PROGRAM

Access to Document

10.1111/jgs.16024Licence: CC BY-NC

Witham_et_al_JAGS_Effect_of_vitamin_K2_VoR
© 2019 The Authors. Journal of the American Geriatrics Society published by Wiley Periodicals, Inc. on behalf of The American Geriatrics Society. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. https://creativecommons.org/licenses/by-nc/4.0/
Final published version, 230 KBLicence: CC BY-NC

Cite this

@article{0a659d5792e44ba391fc495476ea6736,

title = "Effect of vitamin K2 on postural sway in older people who fall: a randomised controlled trial",

abstract = "OBJECTIVES: Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people at risk of falls. DESIGN: Parallel‐group double‐blind randomized placebo‐controlled trial. SETTING: Fourteen primary care practices in Scotland, UK. PARTICIPANTS: A total of 95 community‐dwelling participants aged 65 and older with at least two falls, or one injurious fall, in the previous year. INTERVENTION: Once/day placebo, 200 μg or 400 μg of oral vitamin K2 for 1 year. MEASUREMENTS: The primary outcome was anteroposterior sway measured using sway plates at 12 months, adjusted for baseline. Secondary outcomes included the Short Physical Performance Battery, Berg Balance Scale, Timed Up & Go Test, quality of life, health and social care costs, falls, and adverse events. RESULTS: Mean participant age was 75 (standard deviation [SD] = 7) years. Overall, 58 of 95 (61%) were female; 77 of 95 (81%) attended the 12‐month visit. No significant effect of either vitamin K2 dose was seen on the primary outcome of anteroposterior sway (200 μg vs placebo: −.19 cm [95% confidence interval [CI] −.68 to .30; P = .44]; 400 μg vs placebo: .17 cm [95% CI −.33 to .66; P = .50]; or 400 μg vs 200 μg: .36 cm [95% CI −.11 to .83; P = .14]). Adjusted falls rates were similar in each group. No significant treatment effects were seen for other measures of sway or secondary outcomes. Costs were higher in both vitamin K2 arms than in the placebo arm. CONCLUSION: Oral vitamin K2 supplementation did not improve postural sway or physical function in older people at risk of falls. Trial registration: ISRCTN18436190",

keywords = "falls, vitamin K, postural sway, health economic analysis, recruitment, PREVENTION, RISK, K SUPPLEMENTATION, BALANCE, WOMEN, COMMUNITY, PREDICTORS, PROGRAM",

author = "Witham, {Miles D.} and Price, {Rosemary J. G.} and Band, {Margaret M.} and Hannah, {Michael S.} and Fulton, {Roberta L.} and Clarke, {Clare L.} and Donnan, {Peter T.} and Paul McNamee and Vera Cvoro and Soiza, {Roy L.}",

note = "Funding This work was supported by the Chief Scientist Office, Scottish Government, grant number CZH/4/1100 Acknowledgements With thanks to NHS Support for Science for supporting the trial; the participants for agreeing to take part, and NHS Research Scotland Primary Care Network for their help recruiting participants. We thank Petra Rauchhaus for statistical advice during preparation of the statistical analysis plan for this trial, and Tayside Clinical Trials Unit for their assistance with the management of the trial. The design, results analysis and manuscript drafting were all performed independently with no input from the Sponsor (Tayside Academic Sciences Centre; a joint enterprise between University of Dundee and NHS Tayside). The full protocol, statistical and health economic analysis plans are available from the corresponding author on request. Professor Witham acknowledges support from the NIHR Newcastle Biomedical Research Centre; British Geriatrics Society Spring Scientific Meeting 2019 ; Conference date: 10-04-2019 Through 10-04-2019",

year = "2019",

month = oct,

doi = "10.1111/jgs.16024",

language = "English",

volume = "67",

pages = "2102--2107",

journal = "Journal of the American Geriatrics Society",

issn = "0002-8614",

publisher = "Wiley-Blackwell ",

number = "10",

}

TY - JOUR

T1 - Effect of vitamin K2 on postural sway in older people who fall

T2 - British Geriatrics Society Spring Scientific Meeting 2019

AU - Witham, Miles D.

AU - Price, Rosemary J. G.

AU - Band, Margaret M.

AU - Hannah, Michael S.

AU - Fulton, Roberta L.

AU - Clarke, Clare L.

AU - Donnan, Peter T.

AU - McNamee, Paul

AU - Cvoro, Vera

AU - Soiza, Roy L.

N1 - Funding This work was supported by the Chief Scientist Office, Scottish Government, grant number CZH/4/1100 Acknowledgements With thanks to NHS Support for Science for supporting the trial; the participants for agreeing to take part, and NHS Research Scotland Primary Care Network for their help recruiting participants. We thank Petra Rauchhaus for statistical advice during preparation of the statistical analysis plan for this trial, and Tayside Clinical Trials Unit for their assistance with the management of the trial. The design, results analysis and manuscript drafting were all performed independently with no input from the Sponsor (Tayside Academic Sciences Centre; a joint enterprise between University of Dundee and NHS Tayside). The full protocol, statistical and health economic analysis plans are available from the corresponding author on request. Professor Witham acknowledges support from the NIHR Newcastle Biomedical Research Centre

PY - 2019/10

Y1 - 2019/10

N2 - OBJECTIVES: Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people at risk of falls. DESIGN: Parallel‐group double‐blind randomized placebo‐controlled trial. SETTING: Fourteen primary care practices in Scotland, UK. PARTICIPANTS: A total of 95 community‐dwelling participants aged 65 and older with at least two falls, or one injurious fall, in the previous year. INTERVENTION: Once/day placebo, 200 μg or 400 μg of oral vitamin K2 for 1 year. MEASUREMENTS: The primary outcome was anteroposterior sway measured using sway plates at 12 months, adjusted for baseline. Secondary outcomes included the Short Physical Performance Battery, Berg Balance Scale, Timed Up & Go Test, quality of life, health and social care costs, falls, and adverse events. RESULTS: Mean participant age was 75 (standard deviation [SD] = 7) years. Overall, 58 of 95 (61%) were female; 77 of 95 (81%) attended the 12‐month visit. No significant effect of either vitamin K2 dose was seen on the primary outcome of anteroposterior sway (200 μg vs placebo: −.19 cm [95% confidence interval [CI] −.68 to .30; P = .44]; 400 μg vs placebo: .17 cm [95% CI −.33 to .66; P = .50]; or 400 μg vs 200 μg: .36 cm [95% CI −.11 to .83; P = .14]). Adjusted falls rates were similar in each group. No significant treatment effects were seen for other measures of sway or secondary outcomes. Costs were higher in both vitamin K2 arms than in the placebo arm. CONCLUSION: Oral vitamin K2 supplementation did not improve postural sway or physical function in older people at risk of falls. Trial registration: ISRCTN18436190

AB - OBJECTIVES: Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people at risk of falls. DESIGN: Parallel‐group double‐blind randomized placebo‐controlled trial. SETTING: Fourteen primary care practices in Scotland, UK. PARTICIPANTS: A total of 95 community‐dwelling participants aged 65 and older with at least two falls, or one injurious fall, in the previous year. INTERVENTION: Once/day placebo, 200 μg or 400 μg of oral vitamin K2 for 1 year. MEASUREMENTS: The primary outcome was anteroposterior sway measured using sway plates at 12 months, adjusted for baseline. Secondary outcomes included the Short Physical Performance Battery, Berg Balance Scale, Timed Up & Go Test, quality of life, health and social care costs, falls, and adverse events. RESULTS: Mean participant age was 75 (standard deviation [SD] = 7) years. Overall, 58 of 95 (61%) were female; 77 of 95 (81%) attended the 12‐month visit. No significant effect of either vitamin K2 dose was seen on the primary outcome of anteroposterior sway (200 μg vs placebo: −.19 cm [95% confidence interval [CI] −.68 to .30; P = .44]; 400 μg vs placebo: .17 cm [95% CI −.33 to .66; P = .50]; or 400 μg vs 200 μg: .36 cm [95% CI −.11 to .83; P = .14]). Adjusted falls rates were similar in each group. No significant treatment effects were seen for other measures of sway or secondary outcomes. Costs were higher in both vitamin K2 arms than in the placebo arm. CONCLUSION: Oral vitamin K2 supplementation did not improve postural sway or physical function in older people at risk of falls. Trial registration: ISRCTN18436190

KW - falls

KW - vitamin K

KW - postural sway

KW - health economic analysis

KW - recruitment

KW - PREVENTION

KW - RISK

KW - K SUPPLEMENTATION

KW - BALANCE

KW - WOMEN

KW - COMMUNITY

KW - PREDICTORS

KW - PROGRAM

UR - http://www.scopus.com/inward/record.url?scp=85067844530&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/effect-vitamin-k2-postural-sway-older-people-fall-randomized-controlled-trial

U2 - 10.1111/jgs.16024

DO - 10.1111/jgs.16024

M3 - Article

C2 - 31211416

SN - 0002-8614

VL - 67

SP - 2102

EP - 2107

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

IS - 10

Y2 - 10 April 2019 through 10 April 2019

ER -

Effect of vitamin K2 on postural sway in older people who fall: a randomised controlled trial

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Paul McNamee

Roy Soiza

Cite this

Effect of vitamin K2 on postural sway in older people who fall: a randomised controlled trial

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Profiles

Paul McNamee

Roy Soiza

Cite this