Effect of vitamin K2 on postural sway in older people who fall: a randomised controlled trial

Miles D. Witham (Corresponding Author), Rosemary J. G. Price, Margaret M. Band, Michael S. Hannah, Roberta L. Fulton, Clare L. Clarke, Peter T. Donnan, Paul McNamee, Vera Cvoro, Roy L. Soiza

Research output: Contribution to journalArticle

Abstract

OBJECTIVES Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people at risk of falls. DESIGN Parallel‐group double‐blind randomized placebo‐controlled trial. SETTING Fourteen primary care practices in Scotland, UK. PARTICIPANTS A total of 95 community‐dwelling participants aged 65 and older with at least two falls, or one injurious fall, in the previous year. INTERVENTION Once/day placebo, 200 μg or 400 μg of oral vitamin K2 for 1 year. MEASUREMENTS The primary outcome was anteroposterior sway measured using sway plates at 12 months, adjusted for baseline. Secondary outcomes included the Short Physical Performance Battery, Berg Balance Scale, Timed Up & Go Test, quality of life, health and social care costs, falls, and adverse events. RESULTS Mean participant age was 75 (standard deviation [SD] = 7) years. Overall, 58 of 95 (61%) were female; 77 of 95 (81%) attended the 12‐month visit. No significant effect of either vitamin K2 dose was seen on the primary outcome of anteroposterior sway (200 μg vs placebo: −.19 cm [95% confidence interval [CI] −.68 to .30; P = .44]; 400 μg vs placebo: .17 cm [95% CI −.33 to .66; P = .50]; or 400 μg vs 200 μg: .36 cm [95% CI −.11 to .83; P = .14]). Adjusted falls rates were similar in each group. No significant treatment effects were seen for other measures of sway or secondary outcomes. Costs were higher in both vitamin K2 arms than in the placebo arm. CONCLUSION Oral vitamin K2 supplementation did not improve postural sway or physical function in older people at risk of falls. Trial registration: ISRCTN18436190
Original languageEnglish
Number of pages6
JournalJournal of the American Geriatrics Society
Early online date18 Jun 2019
DOIs
Publication statusE-pub ahead of print - 18 Jun 2019
EventBritish Geriatrics Society Spring Scientific Meeting 2019 - Cardiff, United Kingdom
Duration: 10 Apr 201910 Apr 2019

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Vitamin K 2
Randomized Controlled Trials
Placebos
Confidence Intervals
Health Care Costs
Scotland
Primary Health Care
Maintenance
Quality of Life
Costs and Cost Analysis
Bone and Bones
Health

Keywords

  • falls
  • vitamin K
  • postural sway
  • health economic analysis
  • recruitment

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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Effect of vitamin K2 on postural sway in older people who fall : a randomised controlled trial. / Witham, Miles D. (Corresponding Author); Price, Rosemary J. G.; Band, Margaret M.; Hannah, Michael S.; Fulton, Roberta L.; Clarke, Clare L.; Donnan, Peter T.; McNamee, Paul; Cvoro, Vera; Soiza, Roy L.

In: Journal of the American Geriatrics Society, 18.06.2019.

Research output: Contribution to journalArticle

Witham, Miles D. ; Price, Rosemary J. G. ; Band, Margaret M. ; Hannah, Michael S. ; Fulton, Roberta L. ; Clarke, Clare L. ; Donnan, Peter T. ; McNamee, Paul ; Cvoro, Vera ; Soiza, Roy L. / Effect of vitamin K2 on postural sway in older people who fall : a randomised controlled trial. In: Journal of the American Geriatrics Society. 2019.
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title = "Effect of vitamin K2 on postural sway in older people who fall: a randomised controlled trial",
abstract = "OBJECTIVES Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people at risk of falls. DESIGN Parallel‐group double‐blind randomized placebo‐controlled trial. SETTING Fourteen primary care practices in Scotland, UK. PARTICIPANTS A total of 95 community‐dwelling participants aged 65 and older with at least two falls, or one injurious fall, in the previous year. INTERVENTION Once/day placebo, 200 μg or 400 μg of oral vitamin K2 for 1 year. MEASUREMENTS The primary outcome was anteroposterior sway measured using sway plates at 12 months, adjusted for baseline. Secondary outcomes included the Short Physical Performance Battery, Berg Balance Scale, Timed Up & Go Test, quality of life, health and social care costs, falls, and adverse events. RESULTS Mean participant age was 75 (standard deviation [SD] = 7) years. Overall, 58 of 95 (61{\%}) were female; 77 of 95 (81{\%}) attended the 12‐month visit. No significant effect of either vitamin K2 dose was seen on the primary outcome of anteroposterior sway (200 μg vs placebo: −.19 cm [95{\%} confidence interval [CI] −.68 to .30; P = .44]; 400 μg vs placebo: .17 cm [95{\%} CI −.33 to .66; P = .50]; or 400 μg vs 200 μg: .36 cm [95{\%} CI −.11 to .83; P = .14]). Adjusted falls rates were similar in each group. No significant treatment effects were seen for other measures of sway or secondary outcomes. Costs were higher in both vitamin K2 arms than in the placebo arm. CONCLUSION Oral vitamin K2 supplementation did not improve postural sway or physical function in older people at risk of falls. Trial registration: ISRCTN18436190",
keywords = "falls, vitamin K, postural sway, health economic analysis, recruitment",
author = "Witham, {Miles D.} and Price, {Rosemary J. G.} and Band, {Margaret M.} and Hannah, {Michael S.} and Fulton, {Roberta L.} and Clarke, {Clare L.} and Donnan, {Peter T.} and Paul McNamee and Vera Cvoro and Soiza, {Roy L.}",
note = "Funding This work was supported by the Chief Scientist Office, Scottish Government, grant number CZH/4/1100 Acknowledgements With thanks to NHS Support for Science for supporting the trial; the participants for agreeing to take part, and NHS Research Scotland Primary Care Network for their help recruiting participants. We thank Petra Rauchhaus for statistical advice during preparation of the statistical analysis plan for this trial, and Tayside Clinical Trials Unit for their assistance with the management of the trial. The design, results analysis and manuscript drafting were all performed independently with no input from the Sponsor (Tayside Academic Sciences Centre; a joint enterprise between University of Dundee and NHS Tayside). The full protocol, statistical and health economic analysis plans are available from the corresponding author on request. Professor Witham acknowledges support from the NIHR Newcastle Biomedical Research Centre",
year = "2019",
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TY - JOUR

T1 - Effect of vitamin K2 on postural sway in older people who fall

T2 - a randomised controlled trial

AU - Witham, Miles D.

AU - Price, Rosemary J. G.

AU - Band, Margaret M.

AU - Hannah, Michael S.

AU - Fulton, Roberta L.

AU - Clarke, Clare L.

AU - Donnan, Peter T.

AU - McNamee, Paul

AU - Cvoro, Vera

AU - Soiza, Roy L.

N1 - Funding This work was supported by the Chief Scientist Office, Scottish Government, grant number CZH/4/1100 Acknowledgements With thanks to NHS Support for Science for supporting the trial; the participants for agreeing to take part, and NHS Research Scotland Primary Care Network for their help recruiting participants. We thank Petra Rauchhaus for statistical advice during preparation of the statistical analysis plan for this trial, and Tayside Clinical Trials Unit for their assistance with the management of the trial. The design, results analysis and manuscript drafting were all performed independently with no input from the Sponsor (Tayside Academic Sciences Centre; a joint enterprise between University of Dundee and NHS Tayside). The full protocol, statistical and health economic analysis plans are available from the corresponding author on request. Professor Witham acknowledges support from the NIHR Newcastle Biomedical Research Centre

PY - 2019/6/18

Y1 - 2019/6/18

N2 - OBJECTIVES Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people at risk of falls. DESIGN Parallel‐group double‐blind randomized placebo‐controlled trial. SETTING Fourteen primary care practices in Scotland, UK. PARTICIPANTS A total of 95 community‐dwelling participants aged 65 and older with at least two falls, or one injurious fall, in the previous year. INTERVENTION Once/day placebo, 200 μg or 400 μg of oral vitamin K2 for 1 year. MEASUREMENTS The primary outcome was anteroposterior sway measured using sway plates at 12 months, adjusted for baseline. Secondary outcomes included the Short Physical Performance Battery, Berg Balance Scale, Timed Up & Go Test, quality of life, health and social care costs, falls, and adverse events. RESULTS Mean participant age was 75 (standard deviation [SD] = 7) years. Overall, 58 of 95 (61%) were female; 77 of 95 (81%) attended the 12‐month visit. No significant effect of either vitamin K2 dose was seen on the primary outcome of anteroposterior sway (200 μg vs placebo: −.19 cm [95% confidence interval [CI] −.68 to .30; P = .44]; 400 μg vs placebo: .17 cm [95% CI −.33 to .66; P = .50]; or 400 μg vs 200 μg: .36 cm [95% CI −.11 to .83; P = .14]). Adjusted falls rates were similar in each group. No significant treatment effects were seen for other measures of sway or secondary outcomes. Costs were higher in both vitamin K2 arms than in the placebo arm. CONCLUSION Oral vitamin K2 supplementation did not improve postural sway or physical function in older people at risk of falls. Trial registration: ISRCTN18436190

AB - OBJECTIVES Vitamin K is thought to be involved in both bone health and maintenance of neuromuscular function. We tested the effect of vitamin K2 supplementation on postural sway, falls, healthcare costs, and indices of physical function in older people at risk of falls. DESIGN Parallel‐group double‐blind randomized placebo‐controlled trial. SETTING Fourteen primary care practices in Scotland, UK. PARTICIPANTS A total of 95 community‐dwelling participants aged 65 and older with at least two falls, or one injurious fall, in the previous year. INTERVENTION Once/day placebo, 200 μg or 400 μg of oral vitamin K2 for 1 year. MEASUREMENTS The primary outcome was anteroposterior sway measured using sway plates at 12 months, adjusted for baseline. Secondary outcomes included the Short Physical Performance Battery, Berg Balance Scale, Timed Up & Go Test, quality of life, health and social care costs, falls, and adverse events. RESULTS Mean participant age was 75 (standard deviation [SD] = 7) years. Overall, 58 of 95 (61%) were female; 77 of 95 (81%) attended the 12‐month visit. No significant effect of either vitamin K2 dose was seen on the primary outcome of anteroposterior sway (200 μg vs placebo: −.19 cm [95% confidence interval [CI] −.68 to .30; P = .44]; 400 μg vs placebo: .17 cm [95% CI −.33 to .66; P = .50]; or 400 μg vs 200 μg: .36 cm [95% CI −.11 to .83; P = .14]). Adjusted falls rates were similar in each group. No significant treatment effects were seen for other measures of sway or secondary outcomes. Costs were higher in both vitamin K2 arms than in the placebo arm. CONCLUSION Oral vitamin K2 supplementation did not improve postural sway or physical function in older people at risk of falls. Trial registration: ISRCTN18436190

KW - falls

KW - vitamin K

KW - postural sway

KW - health economic analysis

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DO - 10.1111/jgs.16024

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JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

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