TY - JOUR
T1 - Elucidating the neuropathologic mechanisms of SARS-CoV-2 infection
AU - Pacheco-Herrero, Mar
AU - Soto-Rojas, Luis O
AU - Harrington, Charles
AU - Flores Martinez, Yazmin M.
AU - Villegas-Rojas, Marcos M
AU - León-Aguilar, Alfredo M.
AU - Martínez-Gómez, Paola A
AU - Campa-Córdoba, B. Berenice
AU - Apátiga-Pérez, Ricardo
AU - Corniel-Taveras, Carolin N.
AU - Dominguez-García, Jesabelle de J.
AU - Blanco-Alvarez, Victor Manuel
AU - Luna-Muñoz, José
N1 - Acknowledgements
We want to express our gratitude to the Union Medical University Clinic, Dominican Republic, for their support and collaboration in the development of this research project. We also want to express our gratitude to the Mexican families who have donated the brain of their loved ones affected with Alzheimer's disease and made our research possible. This work is dedicated to the memory of Professor Dr. José Raúl Mena López†.
PY - 2021/4/12
Y1 - 2021/4/12
N2 - The current pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus disease 2019 (COVID-19) has caused about 114 million accumulated cases and 2.53 million deaths worldwide. Previous pieces of evidence suggest that SARS-CoV-2 may affect the central nervous system (CNS) and cause neurological symptoms in COVID-19 patients. It is also known that angiotensin-converting enzyme-2 (ACE2), the primary receptor for SARS-CoV-2 infection, is expressed in different brain areas and cell types. Thus, it is hypothesized that infection by this virus could generate or exacerbate neuropathological alterations. However, the molecular mechanisms that link COVID-19 disease and nerve damage are unclear. In this review, we describe the routes of SARS-CoV-2 invasion into the central nervous system. We also analyze the neuropathologic mechanisms underlying this viral infection, and their potential relationship with the neurological manifestations described in patients with COVID-19, and the appearance or exacerbation of some neurodegenerative diseases.
AB - The current pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus disease 2019 (COVID-19) has caused about 114 million accumulated cases and 2.53 million deaths worldwide. Previous pieces of evidence suggest that SARS-CoV-2 may affect the central nervous system (CNS) and cause neurological symptoms in COVID-19 patients. It is also known that angiotensin-converting enzyme-2 (ACE2), the primary receptor for SARS-CoV-2 infection, is expressed in different brain areas and cell types. Thus, it is hypothesized that infection by this virus could generate or exacerbate neuropathological alterations. However, the molecular mechanisms that link COVID-19 disease and nerve damage are unclear. In this review, we describe the routes of SARS-CoV-2 invasion into the central nervous system. We also analyze the neuropathologic mechanisms underlying this viral infection, and their potential relationship with the neurological manifestations described in patients with COVID-19, and the appearance or exacerbation of some neurodegenerative diseases.
KW - SARS-CoV-2
KW - storm cytokine syndrome
KW - neuroinflammation
KW - blood-brain barrier
KW - neurological alterations
KW - Alzheimer’s disease
U2 - 10.3389/fneur.2021.660087
DO - 10.3389/fneur.2021.660087
M3 - Article
C2 - 33912129
VL - 12
JO - Frontiers in Neurology
JF - Frontiers in Neurology
SN - 1664-2295
M1 - 660087
ER -