Environmental and metabolic sensors that control T cell biology

George Ramsay, Doreen Cantrell*

*Corresponding author for this work

Research output: Contribution to journalReview article

22 Citations (Scopus)
1 Downloads (Pure)

Abstract

The T lymphocyte response to pathogens is shaped by the microenvironment. Environmental sensors in T cells include the nutrient-sensing serine/threonine kinases, adenosine monophosphate-activated protein kinase and mammalian target of rapamycin complex 1. Other environmental sensors are transcription factors such as hypoxia-inducible factor-1 and the aryl hydrocarbon receptor. The present review explores the molecular basis for the impact of environmental signals on the differentiation of conventional T cell receptor αβ T cells and how the T cell response to immune stimuli can coordinate the T cell response to environmental cues.

Original languageEnglish
Article number99
JournalFrontiers in Immunology
Volume6
Early online date17 Mar 2015
DOIs
Publication statusPublished - 17 Mar 2015

Fingerprint

Cell Biology
T-Lymphocytes
Hypoxia-Inducible Factor 1
Aryl Hydrocarbon Receptors
Protein-Serine-Threonine Kinases
Adenosine Monophosphate
T-Cell Antigen Receptor
Protein Kinases
Cues
Transcription Factors
Food

Keywords

  • Amino acid uptake
  • Aryl hydrocarbon
  • Glucose uptake
  • Hypoxia
  • Leucine and mTOR
  • Microbiome
  • T cell metabolism

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Environmental and metabolic sensors that control T cell biology. / Ramsay, George; Cantrell, Doreen.

In: Frontiers in Immunology, Vol. 6, 99, 17.03.2015.

Research output: Contribution to journalReview article

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