ESCMID-ECMM guideline: diagnosis and management of invasive aspergillosis in neonates and children

Adilia Warris (Corresponding Author), Thomas Lehrnbecher, Emmanuel Roilides, Elio Castagnola, Roger J. M. Bruggemann, Andreas H. Groll

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Scope: Presenting symptoms, distributions and patterns of diseases and vulnerability to invasive aspergillosis (IA) are similar between children and adults. However, differences exist in the epidemiology and underlying conditions, the usefulness of newer diagnostic tools, the pharmacology of antifungal agents and in the evidence from interventional phase III clinical trials. Therefore, the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) and the European Confederation of Medical Mycology (ECMM) have developed a paediatric specific guideline for the diagnosis and management of IA in neonates and children.


Methods: Review and discussion of the scientific literature and grading of the available quality of evidence was performed by the paediatric subgroup of the ESCMID-ECMMEuropean Respiratory Society (ERS) Aspergillus disease guideline working group, which was assigned the mandate for the development of neonatal and paediatric specific recommendations.


Questions: Questions addressed by the guideline included the epidemiology of IA in neonates and children; which paediatric patients may benefit from antifungal prophylaxis; how to diagnose IA in neonates and children; which antifungal agents are available for use in neonates and children; which antifungal agents are suitable for prophylaxis and treatment of IA in neonates and children; what is the role of therapeutic drug monitoring of azole antifungals and which management strategies are suitable to be used in paediatric patients. This guideline provides recommendations for the diagnosis, prevention and treatment of IA in the paediatric population, including neonates. The aim of this guideline is to facilitate optimal management of neonates and children at risk for or diagnosed with IA.
Original languageEnglish
Pages (from-to)1096-1113
Number of pages18
JournalClinical Microbiology and Infection
Volume25
Issue number9
Early online date31 May 2019
DOIs
Publication statusPublished - Sep 2019

Fingerprint

Mycology
Aspergillosis
Microbiology
Communicable Diseases
Newborn Infant
Guidelines
Pediatrics
Antifungal Agents
Epidemiology
Literature
Azoles
Phase III Clinical Trials
Drug Monitoring
Aspergillus
Pharmacology
Therapeutics

Keywords

  • antifungal prophylaxis
  • antifungal therapy
  • aspergillosis
  • neonates,children
  • Antifungal therapy
  • Neonates
  • Aspergillosis
  • Antifungal prophylaxis
  • Children
  • BRONCHOALVEOLAR LAVAGE GALACTOMANNAN
  • POPULATION PHARMACOKINETIC ANALYSIS
  • CHRONIC GRANULOMATOUS-DISEASE
  • EMPIRICAL ANTIFUNGAL THERAPY
  • BETA-D-GLUCAN
  • LIPOSOMAL AMPHOTERICIN-B
  • PEDIATRIC CANCER-PATIENTS
  • POLYMERASE-CHAIN-REACTION
  • ITRACONAZOLE ORAL SOLUTION
  • STEM-CELL TRANSPLANTATION

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Warris, A., Lehrnbecher, T., Roilides, E., Castagnola, E., Bruggemann, R. J. M., & Groll, A. H. (2019). ESCMID-ECMM guideline: diagnosis and management of invasive aspergillosis in neonates and children. Clinical Microbiology and Infection, 25(9), 1096-1113. https://doi.org/10.1016/j.cmi.2019.05.019

ESCMID-ECMM guideline : diagnosis and management of invasive aspergillosis in neonates and children. / Warris, Adilia (Corresponding Author); Lehrnbecher, Thomas; Roilides, Emmanuel; Castagnola, Elio; Bruggemann, Roger J. M.; Groll, Andreas H.

In: Clinical Microbiology and Infection, Vol. 25, No. 9, 09.2019, p. 1096-1113.

Research output: Contribution to journalArticle

Warris, A, Lehrnbecher, T, Roilides, E, Castagnola, E, Bruggemann, RJM & Groll, AH 2019, 'ESCMID-ECMM guideline: diagnosis and management of invasive aspergillosis in neonates and children', Clinical Microbiology and Infection, vol. 25, no. 9, pp. 1096-1113. https://doi.org/10.1016/j.cmi.2019.05.019
Warris, Adilia ; Lehrnbecher, Thomas ; Roilides, Emmanuel ; Castagnola, Elio ; Bruggemann, Roger J. M. ; Groll, Andreas H. / ESCMID-ECMM guideline : diagnosis and management of invasive aspergillosis in neonates and children. In: Clinical Microbiology and Infection. 2019 ; Vol. 25, No. 9. pp. 1096-1113.
@article{af5eb78297014ccca919497d0bcaecff,
title = "ESCMID-ECMM guideline: diagnosis and management of invasive aspergillosis in neonates and children",
abstract = "Scope: Presenting symptoms, distributions and patterns of diseases and vulnerability to invasive aspergillosis (IA) are similar between children and adults. However, differences exist in the epidemiology and underlying conditions, the usefulness of newer diagnostic tools, the pharmacology of antifungal agents and in the evidence from interventional phase III clinical trials. Therefore, the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) and the European Confederation of Medical Mycology (ECMM) have developed a paediatric specific guideline for the diagnosis and management of IA in neonates and children.Methods: Review and discussion of the scientific literature and grading of the available quality of evidence was performed by the paediatric subgroup of the ESCMID-ECMMEuropean Respiratory Society (ERS) Aspergillus disease guideline working group, which was assigned the mandate for the development of neonatal and paediatric specific recommendations.Questions: Questions addressed by the guideline included the epidemiology of IA in neonates and children; which paediatric patients may benefit from antifungal prophylaxis; how to diagnose IA in neonates and children; which antifungal agents are available for use in neonates and children; which antifungal agents are suitable for prophylaxis and treatment of IA in neonates and children; what is the role of therapeutic drug monitoring of azole antifungals and which management strategies are suitable to be used in paediatric patients. This guideline provides recommendations for the diagnosis, prevention and treatment of IA in the paediatric population, including neonates. The aim of this guideline is to facilitate optimal management of neonates and children at risk for or diagnosed with IA.",
keywords = "antifungal prophylaxis, antifungal therapy, aspergillosis, neonates,children, Antifungal therapy, Neonates, Aspergillosis, Antifungal prophylaxis, Children, BRONCHOALVEOLAR LAVAGE GALACTOMANNAN, POPULATION PHARMACOKINETIC ANALYSIS, CHRONIC GRANULOMATOUS-DISEASE, EMPIRICAL ANTIFUNGAL THERAPY, BETA-D-GLUCAN, LIPOSOMAL AMPHOTERICIN-B, PEDIATRIC CANCER-PATIENTS, POLYMERASE-CHAIN-REACTION, ITRACONAZOLE ORAL SOLUTION, STEM-CELL TRANSPLANTATION",
author = "Adilia Warris and Thomas Lehrnbecher and Emmanuel Roilides and Elio Castagnola and Bruggemann, {Roger J. M.} and Groll, {Andreas H.}",
note = "ACKNOWLEDGEMENT Prof Warris is supported by the Wellcome Trust Strategic Award (grant 097377) and the MRC Centre for Medical Mycology (grant MR/N006364/1) at the University of Aberdeen. FUNDING European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and the European Confederation of Medical Mycology (ECMM)",
year = "2019",
month = "9",
doi = "10.1016/j.cmi.2019.05.019",
language = "English",
volume = "25",
pages = "1096--1113",
journal = "Clinical Microbiology and Infection",
issn = "1198-743X",
publisher = "Elsevier",
number = "9",

}

TY - JOUR

T1 - ESCMID-ECMM guideline

T2 - diagnosis and management of invasive aspergillosis in neonates and children

AU - Warris, Adilia

AU - Lehrnbecher, Thomas

AU - Roilides, Emmanuel

AU - Castagnola, Elio

AU - Bruggemann, Roger J. M.

AU - Groll, Andreas H.

N1 - ACKNOWLEDGEMENT Prof Warris is supported by the Wellcome Trust Strategic Award (grant 097377) and the MRC Centre for Medical Mycology (grant MR/N006364/1) at the University of Aberdeen. FUNDING European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and the European Confederation of Medical Mycology (ECMM)

PY - 2019/9

Y1 - 2019/9

N2 - Scope: Presenting symptoms, distributions and patterns of diseases and vulnerability to invasive aspergillosis (IA) are similar between children and adults. However, differences exist in the epidemiology and underlying conditions, the usefulness of newer diagnostic tools, the pharmacology of antifungal agents and in the evidence from interventional phase III clinical trials. Therefore, the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) and the European Confederation of Medical Mycology (ECMM) have developed a paediatric specific guideline for the diagnosis and management of IA in neonates and children.Methods: Review and discussion of the scientific literature and grading of the available quality of evidence was performed by the paediatric subgroup of the ESCMID-ECMMEuropean Respiratory Society (ERS) Aspergillus disease guideline working group, which was assigned the mandate for the development of neonatal and paediatric specific recommendations.Questions: Questions addressed by the guideline included the epidemiology of IA in neonates and children; which paediatric patients may benefit from antifungal prophylaxis; how to diagnose IA in neonates and children; which antifungal agents are available for use in neonates and children; which antifungal agents are suitable for prophylaxis and treatment of IA in neonates and children; what is the role of therapeutic drug monitoring of azole antifungals and which management strategies are suitable to be used in paediatric patients. This guideline provides recommendations for the diagnosis, prevention and treatment of IA in the paediatric population, including neonates. The aim of this guideline is to facilitate optimal management of neonates and children at risk for or diagnosed with IA.

AB - Scope: Presenting symptoms, distributions and patterns of diseases and vulnerability to invasive aspergillosis (IA) are similar between children and adults. However, differences exist in the epidemiology and underlying conditions, the usefulness of newer diagnostic tools, the pharmacology of antifungal agents and in the evidence from interventional phase III clinical trials. Therefore, the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) and the European Confederation of Medical Mycology (ECMM) have developed a paediatric specific guideline for the diagnosis and management of IA in neonates and children.Methods: Review and discussion of the scientific literature and grading of the available quality of evidence was performed by the paediatric subgroup of the ESCMID-ECMMEuropean Respiratory Society (ERS) Aspergillus disease guideline working group, which was assigned the mandate for the development of neonatal and paediatric specific recommendations.Questions: Questions addressed by the guideline included the epidemiology of IA in neonates and children; which paediatric patients may benefit from antifungal prophylaxis; how to diagnose IA in neonates and children; which antifungal agents are available for use in neonates and children; which antifungal agents are suitable for prophylaxis and treatment of IA in neonates and children; what is the role of therapeutic drug monitoring of azole antifungals and which management strategies are suitable to be used in paediatric patients. This guideline provides recommendations for the diagnosis, prevention and treatment of IA in the paediatric population, including neonates. The aim of this guideline is to facilitate optimal management of neonates and children at risk for or diagnosed with IA.

KW - antifungal prophylaxis

KW - antifungal therapy

KW - aspergillosis

KW - neonates,children

KW - Antifungal therapy

KW - Neonates

KW - Aspergillosis

KW - Antifungal prophylaxis

KW - Children

KW - BRONCHOALVEOLAR LAVAGE GALACTOMANNAN

KW - POPULATION PHARMACOKINETIC ANALYSIS

KW - CHRONIC GRANULOMATOUS-DISEASE

KW - EMPIRICAL ANTIFUNGAL THERAPY

KW - BETA-D-GLUCAN

KW - LIPOSOMAL AMPHOTERICIN-B

KW - PEDIATRIC CANCER-PATIENTS

KW - POLYMERASE-CHAIN-REACTION

KW - ITRACONAZOLE ORAL SOLUTION

KW - STEM-CELL TRANSPLANTATION

UR - http://www.scopus.com/inward/record.url?scp=85067697628&partnerID=8YFLogxK

UR - https://linkinghub.elsevier.com/retrieve/pii/S1198743X19302824

UR - http://www.mendeley.com/research/escmidecmm-guideline-diagnosis-management-invasive-aspergillosis-neonates-children

UR - http://europepmc.org/abstract/med/31158517

U2 - 10.1016/j.cmi.2019.05.019

DO - 10.1016/j.cmi.2019.05.019

M3 - Article

VL - 25

SP - 1096

EP - 1113

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

SN - 1198-743X

IS - 9

ER -