Ethnic differences in the impact of male fetal gender on the risk of spontaneous preterm birth

Myrthe J. C. S. Peelen; Brenda M. Kazemier; Anita C. J. Ravelli; Christianne J. M. de Groot; Joris A. M. van der Post; Ben W. J. Mol; Marjolein Kok; Petra J. Hajenius

doi:10.1038/s41372-021-01024-7

Ethnic differences in the impact of male fetal gender on the risk of spontaneous preterm birth

Myrthe J. C. S. Peelen^* (Corresponding Author), Brenda M. Kazemier, Anita C. J. Ravelli, Christianne J. M. de Groot, Joris A. M. van der Post, Ben W. J. Mol, Marjolein Kok, Petra J. Hajenius

^*Corresponding author for this work

Amsterdam UMC

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Objective
To study the impact of fetal gender on the risk of spontaneous preterm birth in various ethnicities.

Study design
National cohort study in which all singleton live births from 25+0 weeks onwards without congenital anomalies were included of African, Asian, and Mediterranean women (1999–2010). Our primary outcome measure was preterm birth before 37 weeks. Per ethnic group, male and female neonates were compared.

Result
In each ethnic group, male fetuses were at increased risk of preterm birth (adjusted odds ratio (aOR) 1.63 for African, aOR 1.71 for Asian, and aOR 1.84 for Mediterranean males). The population-attributable risk of male gender on spontaneous preterm birth is lower in African women (3.9%) than in Asian (10.3%) and Mediterranean women (9.0%).

Conclusion
Male fetal gender is associated with spontaneous preterm birth in African, Asian, and Mediterranean women, but the total impact of ethnicity on spontaneous preterm birth rate is different.

Original language	English
Pages (from-to)	2165-2172
Number of pages	8
Journal	Journal of Perinatology
Volume	41
Early online date	9 Mar 2021
DOIs	https://doi.org/10.1038/s41372-021-01024-7
Publication status	Published - Sept 2021

Bibliographical note

Acknowledgements
We thank all Dutch midwives, obstetricians, neonatologists, and other perinatal health care providers for the registration of perinatal information and PERINED (www.perined.nl) for permission (13.63) to use the registry data.

Keywords

Epidemiology
risk factors

Access to Document

10.1038/s41372-021-01024-7Licence: Unspecified

Cite this

@article{72dc15c5d6f5401d82908798dec37e67,

title = "Ethnic differences in the impact of male fetal gender on the risk of spontaneous preterm birth",

abstract = "ObjectiveTo study the impact of fetal gender on the risk of spontaneous preterm birth in various ethnicities.Study designNational cohort study in which all singleton live births from 25+0 weeks onwards without congenital anomalies were included of African, Asian, and Mediterranean women (1999–2010). Our primary outcome measure was preterm birth before 37 weeks. Per ethnic group, male and female neonates were compared.ResultIn each ethnic group, male fetuses were at increased risk of preterm birth (adjusted odds ratio (aOR) 1.63 for African, aOR 1.71 for Asian, and aOR 1.84 for Mediterranean males). The population-attributable risk of male gender on spontaneous preterm birth is lower in African women (3.9%) than in Asian (10.3%) and Mediterranean women (9.0%).ConclusionMale fetal gender is associated with spontaneous preterm birth in African, Asian, and Mediterranean women, but the total impact of ethnicity on spontaneous preterm birth rate is different.",

keywords = "Epidemiology, risk factors",

author = "Peelen, {Myrthe J. C. S.} and Kazemier, {Brenda M.} and Ravelli, {Anita C. J.} and {de Groot}, {Christianne J. M.} and {van der Post}, {Joris A. M.} and Mol, {Ben W. J.} and Marjolein Kok and Hajenius, {Petra J.}",

note = "Acknowledgements We thank all Dutch midwives, obstetricians, neonatologists, and other perinatal health care providers for the registration of perinatal information and PERINED (www.perined.nl) for permission (13.63) to use the registry data.",

year = "2021",

month = sep,

doi = "10.1038/s41372-021-01024-7",

language = "English",

volume = "41",

pages = "2165--2172",

journal = "Journal of Perinatology",

issn = "1476-5543",

}

TY - JOUR

T1 - Ethnic differences in the impact of male fetal gender on the risk of spontaneous preterm birth

AU - Peelen, Myrthe J. C. S.

AU - Kazemier, Brenda M.

AU - Ravelli, Anita C. J.

AU - de Groot, Christianne J. M.

AU - van der Post, Joris A. M.

AU - Mol, Ben W. J.

AU - Kok, Marjolein

AU - Hajenius, Petra J.

N1 - Acknowledgements We thank all Dutch midwives, obstetricians, neonatologists, and other perinatal health care providers for the registration of perinatal information and PERINED (www.perined.nl) for permission (13.63) to use the registry data.

PY - 2021/9

Y1 - 2021/9

N2 - ObjectiveTo study the impact of fetal gender on the risk of spontaneous preterm birth in various ethnicities.Study designNational cohort study in which all singleton live births from 25+0 weeks onwards without congenital anomalies were included of African, Asian, and Mediterranean women (1999–2010). Our primary outcome measure was preterm birth before 37 weeks. Per ethnic group, male and female neonates were compared.ResultIn each ethnic group, male fetuses were at increased risk of preterm birth (adjusted odds ratio (aOR) 1.63 for African, aOR 1.71 for Asian, and aOR 1.84 for Mediterranean males). The population-attributable risk of male gender on spontaneous preterm birth is lower in African women (3.9%) than in Asian (10.3%) and Mediterranean women (9.0%).ConclusionMale fetal gender is associated with spontaneous preterm birth in African, Asian, and Mediterranean women, but the total impact of ethnicity on spontaneous preterm birth rate is different.

AB - ObjectiveTo study the impact of fetal gender on the risk of spontaneous preterm birth in various ethnicities.Study designNational cohort study in which all singleton live births from 25+0 weeks onwards without congenital anomalies were included of African, Asian, and Mediterranean women (1999–2010). Our primary outcome measure was preterm birth before 37 weeks. Per ethnic group, male and female neonates were compared.ResultIn each ethnic group, male fetuses were at increased risk of preterm birth (adjusted odds ratio (aOR) 1.63 for African, aOR 1.71 for Asian, and aOR 1.84 for Mediterranean males). The population-attributable risk of male gender on spontaneous preterm birth is lower in African women (3.9%) than in Asian (10.3%) and Mediterranean women (9.0%).ConclusionMale fetal gender is associated with spontaneous preterm birth in African, Asian, and Mediterranean women, but the total impact of ethnicity on spontaneous preterm birth rate is different.

KW - Epidemiology

KW - risk factors

UR - https://rdcu.be/cxXQi

U2 - 10.1038/s41372-021-01024-7

DO - 10.1038/s41372-021-01024-7

M3 - Article

C2 - 33750936

SN - 1476-5543

VL - 41

SP - 2165

EP - 2172

JO - Journal of Perinatology

JF - Journal of Perinatology

ER -

Ethnic differences in the impact of male fetal gender on the risk of spontaneous preterm birth

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this