EVENT RELATED POTENTIALS, REACTION-TIME, AND COGNITIVE PERFORMANCE IN IDIOPATHIC PARKINSONS-DISEASE

K P EBMEIER, D D POTTER, R H B COCHRANE, John Robertson Crawford, L STEWART, S A CALDER, J A O BESSON, Eric A Salzen

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Sixteen non-demented patients with idiopathic Parkinson's disease (PD) with varying degrees of cognitive impairment and sixteen age-, sex- and education-matched normal controls were examined with (1) an auditory oddball paradigm requiring counting or a motor response in separate determinations, (2) a reaction time task with movement time component and (3) a detailed clinical and neuropsychological test battery. Patients were impaired on a number of neuropsychological tests. They also showed an increased P2 and N2 latency, but no significant increase in P3 latency. Their response initiation times and reaction times during the oddball experiment were not different from controls, whereas movement time was significantly increased. Increased peak latencies, particularly for N2, were moderately associated with Parkinsonian motor impairment in patients and with the Benton Multiple Choice Visual Retention Test in patients and controls. Movement time was associated with P3 latency only in controls and in both groups with the Benton Multiple Choice Visual Retention Test. The observed pattern of results suggests that in non-demented PD patients ERP peak latencies, visuo-spatial task performance and Parkinsonian motor impairment share a significant degree of variance. While impairments in neuropsychological tests and delay in the earlier peaks P2 and N2 do not appear to be sensitive to medication with L-DOPA, normal P3 latencies might indicate good pharmacological symptom control in the absence of dementia.

Original languageEnglish
Pages (from-to)73-89
Number of pages17
JournalBiological Psychology
Volume33
Issue number1
Publication statusPublished - May 1992

Keywords

  • PARKINSONS DISEASE
  • IDIOPATHIC
  • EVENT-RELATED POTENTIALS
  • REACTION TIME
  • COGNITIVE IMPAIRMENT
  • CONTROLLED STUDY
  • BASAL GANGLIA
  • DEFICITS
  • DEMENTIA
  • STATE

Cite this

EBMEIER, K. P., POTTER, D. D., COCHRANE, R. H. B., Crawford, J. R., STEWART, L., CALDER, S. A., ... Salzen, E. A. (1992). EVENT RELATED POTENTIALS, REACTION-TIME, AND COGNITIVE PERFORMANCE IN IDIOPATHIC PARKINSONS-DISEASE. Biological Psychology, 33(1), 73-89.

EVENT RELATED POTENTIALS, REACTION-TIME, AND COGNITIVE PERFORMANCE IN IDIOPATHIC PARKINSONS-DISEASE. / EBMEIER, K P ; POTTER, D D ; COCHRANE, R H B ; Crawford, John Robertson; STEWART, L ; CALDER, S A ; BESSON, J A O ; Salzen, Eric A.

In: Biological Psychology, Vol. 33, No. 1, 05.1992, p. 73-89.

Research output: Contribution to journalArticle

EBMEIER, KP, POTTER, DD, COCHRANE, RHB, Crawford, JR, STEWART, L, CALDER, SA, BESSON, JAO & Salzen, EA 1992, 'EVENT RELATED POTENTIALS, REACTION-TIME, AND COGNITIVE PERFORMANCE IN IDIOPATHIC PARKINSONS-DISEASE' Biological Psychology, vol. 33, no. 1, pp. 73-89.
EBMEIER KP, POTTER DD, COCHRANE RHB, Crawford JR, STEWART L, CALDER SA et al. EVENT RELATED POTENTIALS, REACTION-TIME, AND COGNITIVE PERFORMANCE IN IDIOPATHIC PARKINSONS-DISEASE. Biological Psychology. 1992 May;33(1):73-89.
EBMEIER, K P ; POTTER, D D ; COCHRANE, R H B ; Crawford, John Robertson ; STEWART, L ; CALDER, S A ; BESSON, J A O ; Salzen, Eric A. / EVENT RELATED POTENTIALS, REACTION-TIME, AND COGNITIVE PERFORMANCE IN IDIOPATHIC PARKINSONS-DISEASE. In: Biological Psychology. 1992 ; Vol. 33, No. 1. pp. 73-89.
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