Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine

Shuting Sun, Katarzyna M Błażewska, Anastasia P Kadina, Boris A Kashemirov, Xuchen Duan, James T Triffitt, James E Dunford, R Graham G Russell, Frank H Ebetino, Anke J Roelofs, Fraser Coxon, Mark W Lundy, Charles E McKenna

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A bone imaging toolkit of 21 fluorescent probes with variable spectroscopic properties, bone mineral binding affinities, and antiprenylation activities has been created, including a novel linking strategy. The linking chemistry allows attachment of a diverse selection of dyes fluorescent in the visible to near-infrared range to any of the three clinically important heterocyclic bisphosphonate bone drugs (risedronate, zoledronate, and minodronate or their analogues). The resultant suite of conjugates offers multiple options to "mix and match" parent drug structure, fluorescence emission wavelength, relative bone affinity, and presence or absence of antiprenylation activity, for bone-related imaging applications.

Original languageEnglish
Pages (from-to)329-340
Number of pages12
JournalBioconjugate Chemistry
Volume27
Issue number2
Early online date8 Dec 2015
DOIs
Publication statusPublished - 17 Feb 2016

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Diphosphonates
Bone
Imaging techniques
Bone and Bones
zoledronic acid
Fluorescent Dyes
Pharmaceutical Preparations
Minerals
Dyes
Fluorescence
Infrared radiation
Wavelength

Cite this

Sun, S., Błażewska, K. M., Kadina, A. P., Kashemirov, B. A., Duan, X., Triffitt, J. T., ... McKenna, C. E. (2016). Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine. Bioconjugate Chemistry, 27(2), 329-340. https://doi.org/10.1021/acs.bioconjchem.5b00369

Fluorescent Bisphosphonate and Carboxyphosphonate Probes : A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine. / Sun, Shuting; Błażewska, Katarzyna M; Kadina, Anastasia P; Kashemirov, Boris A; Duan, Xuchen; Triffitt, James T; Dunford, James E; Russell, R Graham G; Ebetino, Frank H; Roelofs, Anke J; Coxon, Fraser; Lundy, Mark W; McKenna, Charles E.

In: Bioconjugate Chemistry, Vol. 27, No. 2, 17.02.2016, p. 329-340.

Research output: Contribution to journalArticle

Sun, S, Błażewska, KM, Kadina, AP, Kashemirov, BA, Duan, X, Triffitt, JT, Dunford, JE, Russell, RGG, Ebetino, FH, Roelofs, AJ, Coxon, F, Lundy, MW & McKenna, CE 2016, 'Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine', Bioconjugate Chemistry, vol. 27, no. 2, pp. 329-340. https://doi.org/10.1021/acs.bioconjchem.5b00369
Sun, Shuting ; Błażewska, Katarzyna M ; Kadina, Anastasia P ; Kashemirov, Boris A ; Duan, Xuchen ; Triffitt, James T ; Dunford, James E ; Russell, R Graham G ; Ebetino, Frank H ; Roelofs, Anke J ; Coxon, Fraser ; Lundy, Mark W ; McKenna, Charles E. / Fluorescent Bisphosphonate and Carboxyphosphonate Probes : A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine. In: Bioconjugate Chemistry. 2016 ; Vol. 27, No. 2. pp. 329-340.
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