Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine

Shuting Sun, Katarzyna M Błażewska, Anastasia P Kadina, Boris A Kashemirov, Xuchen Duan, James T Triffitt, James E Dunford, R Graham G Russell, Frank H Ebetino, Anke J Roelofs, Fraser Coxon, Mark W Lundy, Charles E McKenna

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23 Citations (Scopus)

Abstract

A bone imaging toolkit of 21 fluorescent probes with variable spectroscopic properties, bone mineral binding affinities, and antiprenylation activities has been created, including a novel linking strategy. The linking chemistry allows attachment of a diverse selection of dyes fluorescent in the visible to near-infrared range to any of the three clinically important heterocyclic bisphosphonate bone drugs (risedronate, zoledronate, and minodronate or their analogues). The resultant suite of conjugates offers multiple options to "mix and match" parent drug structure, fluorescence emission wavelength, relative bone affinity, and presence or absence of antiprenylation activity, for bone-related imaging applications.

Original languageEnglish
Pages (from-to)329-340
Number of pages12
JournalBioconjugate Chemistry
Volume27
Issue number2
Early online date8 Dec 2015
DOIs
Publication statusPublished - 17 Feb 2016

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    Sun, S., Błażewska, K. M., Kadina, A. P., Kashemirov, B. A., Duan, X., Triffitt, J. T., Dunford, J. E., Russell, R. G. G., Ebetino, F. H., Roelofs, A. J., Coxon, F., Lundy, M. W., & McKenna, C. E. (2016). Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine. Bioconjugate Chemistry, 27(2), 329-340. https://doi.org/10.1021/acs.bioconjchem.5b00369