Fluorinase mediated C--18 F bond formation, an enzymatic tool for PET labelling

Hai Deng, Steven L. Cobb, Antony D. Gee, Andrew Lockhart, Laurent Martarello (Corresponding Author), Ryan P. McGlinchey, David O'hagan (Corresponding Author), Mayca Onega

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

The fluorinase enzyme from S. cattleya is applied as a catalyst for the efficient incorporation of [18F]-fluoride into [18F]-5'-fluoro-5'-deoxyadenosine, [18F]-5'-fluoro-5'-deoxyinosine and [18F]-5-fluoro-5-deoxyribose for positron emission tomography (PET) applications.

Original languageEnglish
Pages (from-to)652-654
Number of pages3
JournalChemical Communications
Issue number6
DOIs
Publication statusPublished - 18 Jan 2006

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    Deng, H., Cobb, S. L., Gee, A. D., Lockhart, A., Martarello, L., McGlinchey, R. P., O'hagan, D., & Onega, M. (2006). Fluorinase mediated C--18 F bond formation, an enzymatic tool for PET labelling. Chemical Communications, (6), 652-654. https://doi.org/10.1039/B516861A