Fluorine biocatalysis

Linrui Wu, Fleurdeliz Maglangit, Hai Deng (Corresponding Author)

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The introduction of fluorine atoms into organic molecules has received considerable attentions as these organofluorines have often found widespread applications in bioorganic chemistry, medicinal chemistry and
biomaterial science. Despite innovation of synthetic C–F forming methodologies, selective fluorination is still extremely challenging. Therefore, a biotransformation approach using fluorine biocatalysts is needed to selectively
introduce fluorine into structurally diverse molecules. Yet, there are few ways that enable incorporation of fluorine into structurally complex bioactive molecules. One is to extend the substrate scope of the existing enzyme
inventory. Another is to expand the biosynthetic pathways to accept fluorinated precursors for producing fluorinated bioactive molecules. Finally, an understanding of the physiological roles of fluorometabolites in the
producing microorganisms will advance our ability to engineer a microorganism to produce novel fluorinated commodities. Here, we review the fluorinase biotechnology and fluorine biocatalysts that incorporate fluorine
motifs to generate fluorinated molecules, and highlight areas for future developments.
Original languageEnglish
Pages (from-to)119-126
Number of pages6
JournalCurrent Opinion in Chemical Biology
Volume55
Early online date19 Feb 2020
DOIs
Publication statusPublished - Apr 2020

Keywords

  • BB/P00380X/1
  • BB/R00479X/1
  • FLUOROMETABOLITE BIOSYNTHESIS
  • RGD PEPTIDE
  • MECHANISM
  • METABOLISM
  • ENZYMATIC FLUORINATION
  • BOND FORMATION
  • STREPTOMYCES SP MA37
  • IDENTIFICATION
  • F-18
  • ANTIBIOTIC NUCLEOCIDIN

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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