Fos expression in the orbital prefrontal cortex after exposure to the fixed-interval peak procedure

L Valencia-Torres, C M Olarte Sanchez, S Body, K C F Fone, C M Bradshaw, E Szabadi

Research output: Contribution to journalArticle

5 Citations (Scopus)
5 Downloads (Pure)

Abstract

It has been proposed that cortico-striato-thalamo-cortical circuits that incorporate the prefrontal cortex and dorsal striatum regulate interval timing behaviour. The present experiment examined whether performance on the fixed-interval peak procedure (FIPP), an immediate timing schedule, would induce neuronal activity in cortical and striatal areas, as revealed by enhanced expression of the Fos protein, a marker for neuronal activation. Regional Fos expression was compared between rats trained on the FIPP and rats trained on a variable-interval (VI) schedule matched to the FIPP for overall response rate and reinforcer delivery. Response rate in the peak trials of the FIPP conformed to a temporally differentiated pattern, which was well described by a modified Gaussian function; in agreement with previous findings, the peak time occurred close to the time at which the reinforcer was delivered in the fixed-interval trials, and the Weber fraction was within the range of values reported previously. The density of Fos-positive neurones (counts mm(-2)) in the orbital prefrontal cortex (OPFC) was greater in rats exposed to the FIPP than in rats exposed to the VI schedule, suggesting a greater activation of this area during the performance of the former task. This is consistent with the results of previous studies that have implicated the OPFC in interval timing behaviour. However, there was no significant difference between the levels of Fos expression in the dorsal or ventral striatum of the rats trained under the two schedules.
Original languageEnglish
Pages (from-to)372-377
Number of pages6
JournalBehavioural Brain Research
Volume229
Issue number2
Early online date24 Jan 2012
DOIs
Publication statusPublished - 15 Apr 2012

Fingerprint

Prefrontal Cortex
Appointments and Schedules
Corpus Striatum
Task Performance and Analysis
Neurons
Proteins

Keywords

  • animals
  • conditioning, operant
  • corpus striatum
  • female
  • prefrontal cortex
  • proto-oncogene proteins c-fos
  • rats
  • rats, wistar
  • reinforcement schedule
  • time factors

Cite this

Valencia-Torres, L., Olarte Sanchez, C. M., Body, S., Fone, K. C. F., Bradshaw, C. M., & Szabadi, E. (2012). Fos expression in the orbital prefrontal cortex after exposure to the fixed-interval peak procedure. Behavioural Brain Research, 229(2), 372-377. https://doi.org/10.1016/j.bbr.2012.01.035

Fos expression in the orbital prefrontal cortex after exposure to the fixed-interval peak procedure. / Valencia-Torres, L; Olarte Sanchez, C M; Body, S; Fone, K C F; Bradshaw, C M; Szabadi, E.

In: Behavioural Brain Research, Vol. 229, No. 2, 15.04.2012, p. 372-377.

Research output: Contribution to journalArticle

Valencia-Torres, L, Olarte Sanchez, CM, Body, S, Fone, KCF, Bradshaw, CM & Szabadi, E 2012, 'Fos expression in the orbital prefrontal cortex after exposure to the fixed-interval peak procedure', Behavioural Brain Research, vol. 229, no. 2, pp. 372-377. https://doi.org/10.1016/j.bbr.2012.01.035
Valencia-Torres L, Olarte Sanchez CM, Body S, Fone KCF, Bradshaw CM, Szabadi E. Fos expression in the orbital prefrontal cortex after exposure to the fixed-interval peak procedure. Behavioural Brain Research. 2012 Apr 15;229(2):372-377. https://doi.org/10.1016/j.bbr.2012.01.035
Valencia-Torres, L ; Olarte Sanchez, C M ; Body, S ; Fone, K C F ; Bradshaw, C M ; Szabadi, E. / Fos expression in the orbital prefrontal cortex after exposure to the fixed-interval peak procedure. In: Behavioural Brain Research. 2012 ; Vol. 229, No. 2. pp. 372-377.
@article{8205c6df27764776a043a5e9affa2117,
title = "Fos expression in the orbital prefrontal cortex after exposure to the fixed-interval peak procedure",
abstract = "It has been proposed that cortico-striato-thalamo-cortical circuits that incorporate the prefrontal cortex and dorsal striatum regulate interval timing behaviour. The present experiment examined whether performance on the fixed-interval peak procedure (FIPP), an immediate timing schedule, would induce neuronal activity in cortical and striatal areas, as revealed by enhanced expression of the Fos protein, a marker for neuronal activation. Regional Fos expression was compared between rats trained on the FIPP and rats trained on a variable-interval (VI) schedule matched to the FIPP for overall response rate and reinforcer delivery. Response rate in the peak trials of the FIPP conformed to a temporally differentiated pattern, which was well described by a modified Gaussian function; in agreement with previous findings, the peak time occurred close to the time at which the reinforcer was delivered in the fixed-interval trials, and the Weber fraction was within the range of values reported previously. The density of Fos-positive neurones (counts mm(-2)) in the orbital prefrontal cortex (OPFC) was greater in rats exposed to the FIPP than in rats exposed to the VI schedule, suggesting a greater activation of this area during the performance of the former task. This is consistent with the results of previous studies that have implicated the OPFC in interval timing behaviour. However, there was no significant difference between the levels of Fos expression in the dorsal or ventral striatum of the rats trained under the two schedules.",
keywords = "animals, conditioning, operant, corpus striatum, female, prefrontal cortex, proto-oncogene proteins c-fos, rats, rats, wistar, reinforcement schedule, time factors",
author = "L Valencia-Torres and {Olarte Sanchez}, {C M} and S Body and Fone, {K C F} and Bradshaw, {C M} and E Szabadi",
note = "Copyright {\circledC} 2012 Elsevier B.V. All rights reserved.",
year = "2012",
month = "4",
day = "15",
doi = "10.1016/j.bbr.2012.01.035",
language = "English",
volume = "229",
pages = "372--377",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Fos expression in the orbital prefrontal cortex after exposure to the fixed-interval peak procedure

AU - Valencia-Torres, L

AU - Olarte Sanchez, C M

AU - Body, S

AU - Fone, K C F

AU - Bradshaw, C M

AU - Szabadi, E

N1 - Copyright © 2012 Elsevier B.V. All rights reserved.

PY - 2012/4/15

Y1 - 2012/4/15

N2 - It has been proposed that cortico-striato-thalamo-cortical circuits that incorporate the prefrontal cortex and dorsal striatum regulate interval timing behaviour. The present experiment examined whether performance on the fixed-interval peak procedure (FIPP), an immediate timing schedule, would induce neuronal activity in cortical and striatal areas, as revealed by enhanced expression of the Fos protein, a marker for neuronal activation. Regional Fos expression was compared between rats trained on the FIPP and rats trained on a variable-interval (VI) schedule matched to the FIPP for overall response rate and reinforcer delivery. Response rate in the peak trials of the FIPP conformed to a temporally differentiated pattern, which was well described by a modified Gaussian function; in agreement with previous findings, the peak time occurred close to the time at which the reinforcer was delivered in the fixed-interval trials, and the Weber fraction was within the range of values reported previously. The density of Fos-positive neurones (counts mm(-2)) in the orbital prefrontal cortex (OPFC) was greater in rats exposed to the FIPP than in rats exposed to the VI schedule, suggesting a greater activation of this area during the performance of the former task. This is consistent with the results of previous studies that have implicated the OPFC in interval timing behaviour. However, there was no significant difference between the levels of Fos expression in the dorsal or ventral striatum of the rats trained under the two schedules.

AB - It has been proposed that cortico-striato-thalamo-cortical circuits that incorporate the prefrontal cortex and dorsal striatum regulate interval timing behaviour. The present experiment examined whether performance on the fixed-interval peak procedure (FIPP), an immediate timing schedule, would induce neuronal activity in cortical and striatal areas, as revealed by enhanced expression of the Fos protein, a marker for neuronal activation. Regional Fos expression was compared between rats trained on the FIPP and rats trained on a variable-interval (VI) schedule matched to the FIPP for overall response rate and reinforcer delivery. Response rate in the peak trials of the FIPP conformed to a temporally differentiated pattern, which was well described by a modified Gaussian function; in agreement with previous findings, the peak time occurred close to the time at which the reinforcer was delivered in the fixed-interval trials, and the Weber fraction was within the range of values reported previously. The density of Fos-positive neurones (counts mm(-2)) in the orbital prefrontal cortex (OPFC) was greater in rats exposed to the FIPP than in rats exposed to the VI schedule, suggesting a greater activation of this area during the performance of the former task. This is consistent with the results of previous studies that have implicated the OPFC in interval timing behaviour. However, there was no significant difference between the levels of Fos expression in the dorsal or ventral striatum of the rats trained under the two schedules.

KW - animals

KW - conditioning, operant

KW - corpus striatum

KW - female

KW - prefrontal cortex

KW - proto-oncogene proteins c-fos

KW - rats

KW - rats, wistar

KW - reinforcement schedule

KW - time factors

U2 - 10.1016/j.bbr.2012.01.035

DO - 10.1016/j.bbr.2012.01.035

M3 - Article

VL - 229

SP - 372

EP - 377

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 2

ER -