Frontal and parietal theta burst TMS impairs working memory for visual-spatial conjunctions

Helen M Morgan, Margaret C Jackson, Martijn G van Koningsbruggen, Kimron L Shapiro, David E J Linden

Research output: Contribution to journalArticle

21 Citations (Scopus)
6 Downloads (Pure)

Abstract

In tasks that selectively probe visual or spatial working memory (WM) frontal and posterior cortical areas show a segregation, with dorsal areas preferentially involved in spatial (e.g. location) WM and ventral areas in visual (e.g. object identity) WM. In a previous fMRI study [1], we showed that right parietal cortex (PC) was more active during WM for orientation, whereas left inferior frontal gyrus (IFG) was more active during colour WM. During WM for colour-orientation conjunctions, activity in these areas was intermediate to the level of activity for the single task preferred and non-preferred information. To examine whether these specialised areas play a critical role in coordinating visual and spatial WM to perform a conjunction task, we used theta burst transcranial magnetic stimulation (TMS) to induce a functional deficit. Compared to sham stimulation, TMS to right PC or left IFG selectively impaired WM for conjunctions but not single features. This is consistent with findings from visual search paradigms, in which frontal and parietal TMS selectively affects search for conjunctions compared to single features, and with combined TMS and functional imaging work suggesting that parietal and frontal regions are functionally coupled in tasks requiring integration of visual and spatial information. Our results thus elucidate mechanisms by which the brain coordinates spatially segregated processing streams and have implications beyond the field of working memory.
Original languageEnglish
Pages (from-to)122-129
Number of pages8
JournalBrain Stimulation
Volume6
Issue number2
Early online date6 Apr 2012
DOIs
Publication statusPublished - Mar 2013

Fingerprint

Transcranial Magnetic Stimulation
Short-Term Memory
Parietal Lobe
Prefrontal Cortex
Color
Magnetic Resonance Imaging
Brain

Keywords

  • working memory
  • transcriptional magnetic stimulation
  • conjunction
  • colour
  • orientation

Cite this

Frontal and parietal theta burst TMS impairs working memory for visual-spatial conjunctions. / Morgan, Helen M; Jackson, Margaret C; van Koningsbruggen, Martijn G; Shapiro, Kimron L; Linden, David E J.

In: Brain Stimulation, Vol. 6, No. 2, 03.2013, p. 122-129.

Research output: Contribution to journalArticle

Morgan, Helen M ; Jackson, Margaret C ; van Koningsbruggen, Martijn G ; Shapiro, Kimron L ; Linden, David E J. / Frontal and parietal theta burst TMS impairs working memory for visual-spatial conjunctions. In: Brain Stimulation. 2013 ; Vol. 6, No. 2. pp. 122-129.
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