Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability

W David Hill, Christiaan de Leeuw, Gail Davies, David Cherry McLachlan Liewald, Anthony Payton, Leone C A Craig, Lawrence J Whalley, Mike Horan, William Ollier, John M Starr, Neil Pendleton, Danielle Posthuma, Timothy C Bates, Ian J Deary

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Abstract

Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including current IQ and childhood IQ, and using both gene- and SNP-based analytic strategies. No significant associations were found between variation in heterotrimeric G protein genes and intelligence in any cohort at either of the two time points. These results indicate that, whereas G protein systems are important in cognition, common genetic variation in these genes is unlikely to be a substantial influence on human intelligence differences.
Original languageEnglish
Article numbere91690
Number of pages8
JournalPloS ONE
Volume9
Issue number3
DOIs
Publication statusPublished - 13 Mar 2014

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Heterotrimeric GTP-Binding Proteins
Aptitude
G-proteins
Genes
Intelligence
Polymorphism
genes
single nucleotide polymorphism
Single Nucleotide Polymorphism
Nucleotides
GTP-Binding Proteins
childhood
cognition
Cognition
genetic variation

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Hill, W. D., de Leeuw, C., Davies, G., Liewald, D. C. M., Payton, A., Craig, L. C. A., ... Deary, I. J. (2014). Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability. PloS ONE, 9(3), [e91690]. https://doi.org/10.1371/journal.pone.0091690

Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability. / Hill, W David; de Leeuw, Christiaan; Davies, Gail; Liewald, David Cherry McLachlan; Payton, Anthony; Craig, Leone C A; Whalley, Lawrence J; Horan, Mike; Ollier, William; Starr, John M; Pendleton, Neil; Posthuma, Danielle; Bates, Timothy C; Deary, Ian J.

In: PloS ONE, Vol. 9, No. 3, e91690, 13.03.2014.

Research output: Contribution to journalArticle

Hill, WD, de Leeuw, C, Davies, G, Liewald, DCM, Payton, A, Craig, LCA, Whalley, LJ, Horan, M, Ollier, W, Starr, JM, Pendleton, N, Posthuma, D, Bates, TC & Deary, IJ 2014, 'Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability', PloS ONE, vol. 9, no. 3, e91690. https://doi.org/10.1371/journal.pone.0091690
Hill, W David ; de Leeuw, Christiaan ; Davies, Gail ; Liewald, David Cherry McLachlan ; Payton, Anthony ; Craig, Leone C A ; Whalley, Lawrence J ; Horan, Mike ; Ollier, William ; Starr, John M ; Pendleton, Neil ; Posthuma, Danielle ; Bates, Timothy C ; Deary, Ian J. / Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability. In: PloS ONE. 2014 ; Vol. 9, No. 3.
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