Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability

W David Hill; Christiaan de Leeuw; Gail Davies; David Cherry McLachlan Liewald; Anthony Payton; Leone C A Craig; Lawrence J Whalley; Mike Horan; William Ollier; John M Starr; Neil Pendleton; Danielle Posthuma; Timothy C Bates; Ian J Deary

doi:10.1371/journal.pone.0091690

Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability

W David Hill, Christiaan de Leeuw, Gail Davies, David Cherry McLachlan Liewald, Anthony Payton, Leone C A Craig, Lawrence J Whalley, Mike Horan, William Ollier, John M Starr, Neil Pendleton, Danielle Posthuma, Timothy C Bates, Ian J Deary

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Abstract

Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including current IQ and childhood IQ, and using both gene- and SNP-based analytic strategies. No significant associations were found between variation in heterotrimeric G protein genes and intelligence in any cohort at either of the two time points. These results indicate that, whereas G protein systems are important in cognition, common genetic variation in these genes is unlikely to be a substantial influence on human intelligence differences.

Original language	English
Article number	e91690
Number of pages	8
Journal	PloS ONE
Volume	9
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0091690
Publication status	Published - 13 Mar 2014

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Functional gene group analysis
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Aberdeen Birth Cohort Study 1936 (ABC 1936)
Craig, L. (Data Manager), University of Aberdeen, 1997
http://www.abdn.ac.uk/aberdeen-birth-cohort/ and one more link, https://www.abdn.ac.uk/birth-cohorts/1936/for-researchers/data-access/?action=subpage (show fewer)
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Hill, W. D., de Leeuw, C., Davies, G., Liewald, D. C. M., Payton, A., Craig, L. C. A., Whalley, L. J., Horan, M., Ollier, W., Starr, J. M., Pendleton, N., Posthuma, D., Bates, T. C., & Deary, I. J. (2014). Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability. PloS ONE, 9(3), Article e91690. https://doi.org/10.1371/journal.pone.0091690

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abstract = "Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including current IQ and childhood IQ, and using both gene- and SNP-based analytic strategies. No significant associations were found between variation in heterotrimeric G protein genes and intelligence in any cohort at either of the two time points. These results indicate that, whereas G protein systems are important in cognition, common genetic variation in these genes is unlikely to be a substantial influence on human intelligence differences.",

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AU - Payton, Anthony

AU - Craig, Leone C A

AU - Whalley, Lawrence J

AU - Horan, Mike

AU - Ollier, William

AU - Starr, John M

AU - Pendleton, Neil

AU - Posthuma, Danielle

AU - Bates, Timothy C

AU - Deary, Ian J

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AB - Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including current IQ and childhood IQ, and using both gene- and SNP-based analytic strategies. No significant associations were found between variation in heterotrimeric G protein genes and intelligence in any cohort at either of the two time points. These results indicate that, whereas G protein systems are important in cognition, common genetic variation in these genes is unlikely to be a substantial influence on human intelligence differences.

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Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability

Abstract

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Aberdeen Birth Cohort Study 1936 (ABC 1936)

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