Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task

Viktoria-Eleni Gountouna, Dominic E. Job, Andrew M. McIntosh, T. William J. Moorhead, G. Katherine L. Lymer, Heather C. Whalley, Jeremy Hall, Gordon David Waiter, David Brennan, David J. McGonigle, Trevor Sean Ahearn, Johnathan Cavanagh, Barrie Condon, Donald. M. Hadley, Ian Marshall, Alison Dorothy Murray, Douglas Steele, Joanna M. Wardlaw, Stephen M. Lawrie

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Multicentre MRI studies offer great potential to increase Study power and flexibility, but it is not yet clear how reproducible the results from multiple centres may be. Here we present results from the multicentre Study 'CaliBrain', examining the reproducibility of fMRI data within and between three sites. Fourteen Subjects were scanned twice on three 1.5 T GE scanners using an identical scanning protocol. We present data from a motor task with three conditions, sequential and random finger tapping and rest. Similar activation maps were obtained for each site and visit; brain areas consistently activated during the task included the premotor, primary motor and supplementary motor areas, the striatum and cerebellum. Reproducibility was evaluated within and between sites by comparing the extent and spatial agreement of activation maps at both the subject and group levels. The results were within the range previously reported for similar tasks on single scanners and both measures were found to be comparable within and between sites, with between site reproducibility similar to the within site measures. A variance components analysis was used to examine the effects of site, subject and visit. The contributions of site and visit were small and reproducibility was similar between and within sites, whereas the variance between subjects, and unexplained variance was large. These findings suggest that we can have confidence in combined results from multicentre fMRI studies, at least when a consistent protocol is followed on similar machines in all participating scanning sites and care is taken to select homogeneous subject groups. (C) 2009 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)552-560
Number of pages9
JournalNeuroimage
Volume49
Issue number1
DOIs
Publication statusPublished - 1 Jan 2010

Keywords

  • fMRI
  • CaliBrain
  • Multicentre
  • Scanner harmonisation
  • Motor
  • Reproducibility
  • Test-Retest reliability
  • Intrasubjct reproductibility
  • Signal change
  • Motor task
  • MR systems
  • Activation
  • Precision
  • multicentre
  • scanner harmonisation
  • motor
  • reproductibility

Cite this

Gountouna, V-E., Job, D. E., McIntosh, A. M., Moorhead, T. W. J., Lymer, G. K. L., Whalley, H. C., ... Lawrie, S. M. (2010). Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task. Neuroimage, 49(1), 552-560. https://doi.org/10.1016/j.neuroimage.2009.07.026

Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task. / Gountouna, Viktoria-Eleni; Job, Dominic E.; McIntosh, Andrew M.; Moorhead, T. William J.; Lymer, G. Katherine L.; Whalley, Heather C.; Hall, Jeremy; Waiter, Gordon David; Brennan, David; McGonigle, David J.; Ahearn, Trevor Sean; Cavanagh, Johnathan; Condon, Barrie; Hadley, Donald. M.; Marshall, Ian; Murray, Alison Dorothy; Steele, Douglas; Wardlaw, Joanna M.; Lawrie, Stephen M. .

In: Neuroimage, Vol. 49, No. 1, 01.01.2010, p. 552-560.

Research output: Contribution to journalArticle

Gountouna, V-E, Job, DE, McIntosh, AM, Moorhead, TWJ, Lymer, GKL, Whalley, HC, Hall, J, Waiter, GD, Brennan, D, McGonigle, DJ, Ahearn, TS, Cavanagh, J, Condon, B, Hadley, DM, Marshall, I, Murray, AD, Steele, D, Wardlaw, JM & Lawrie, SM 2010, 'Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task', Neuroimage, vol. 49, no. 1, pp. 552-560. https://doi.org/10.1016/j.neuroimage.2009.07.026
Gountouna, Viktoria-Eleni ; Job, Dominic E. ; McIntosh, Andrew M. ; Moorhead, T. William J. ; Lymer, G. Katherine L. ; Whalley, Heather C. ; Hall, Jeremy ; Waiter, Gordon David ; Brennan, David ; McGonigle, David J. ; Ahearn, Trevor Sean ; Cavanagh, Johnathan ; Condon, Barrie ; Hadley, Donald. M. ; Marshall, Ian ; Murray, Alison Dorothy ; Steele, Douglas ; Wardlaw, Joanna M. ; Lawrie, Stephen M. . / Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task. In: Neuroimage. 2010 ; Vol. 49, No. 1. pp. 552-560.
@article{3734bb8cc97f47e7915bdc627616a57b,
title = "Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task",
abstract = "Multicentre MRI studies offer great potential to increase Study power and flexibility, but it is not yet clear how reproducible the results from multiple centres may be. Here we present results from the multicentre Study 'CaliBrain', examining the reproducibility of fMRI data within and between three sites. Fourteen Subjects were scanned twice on three 1.5 T GE scanners using an identical scanning protocol. We present data from a motor task with three conditions, sequential and random finger tapping and rest. Similar activation maps were obtained for each site and visit; brain areas consistently activated during the task included the premotor, primary motor and supplementary motor areas, the striatum and cerebellum. Reproducibility was evaluated within and between sites by comparing the extent and spatial agreement of activation maps at both the subject and group levels. The results were within the range previously reported for similar tasks on single scanners and both measures were found to be comparable within and between sites, with between site reproducibility similar to the within site measures. A variance components analysis was used to examine the effects of site, subject and visit. The contributions of site and visit were small and reproducibility was similar between and within sites, whereas the variance between subjects, and unexplained variance was large. These findings suggest that we can have confidence in combined results from multicentre fMRI studies, at least when a consistent protocol is followed on similar machines in all participating scanning sites and care is taken to select homogeneous subject groups. (C) 2009 Elsevier Inc. All rights reserved.",
keywords = "fMRI, CaliBrain, Multicentre, Scanner harmonisation, Motor, Reproducibility, Test-Retest reliability, Intrasubjct reproductibility, Signal change, Motor task, MR systems, Activation, Precision, multicentre, scanner harmonisation, motor, reproductibility",
author = "Viktoria-Eleni Gountouna and Job, {Dominic E.} and McIntosh, {Andrew M.} and Moorhead, {T. William J.} and Lymer, {G. Katherine L.} and Whalley, {Heather C.} and Jeremy Hall and Waiter, {Gordon David} and David Brennan and McGonigle, {David J.} and Ahearn, {Trevor Sean} and Johnathan Cavanagh and Barrie Condon and Hadley, {Donald. M.} and Ian Marshall and Murray, {Alison Dorothy} and Douglas Steele and Wardlaw, {Joanna M.} and Lawrie, {Stephen M.}",
year = "2010",
month = "1",
day = "1",
doi = "10.1016/j.neuroimage.2009.07.026",
language = "English",
volume = "49",
pages = "552--560",
journal = "Neuroimage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task

AU - Gountouna, Viktoria-Eleni

AU - Job, Dominic E.

AU - McIntosh, Andrew M.

AU - Moorhead, T. William J.

AU - Lymer, G. Katherine L.

AU - Whalley, Heather C.

AU - Hall, Jeremy

AU - Waiter, Gordon David

AU - Brennan, David

AU - McGonigle, David J.

AU - Ahearn, Trevor Sean

AU - Cavanagh, Johnathan

AU - Condon, Barrie

AU - Hadley, Donald. M.

AU - Marshall, Ian

AU - Murray, Alison Dorothy

AU - Steele, Douglas

AU - Wardlaw, Joanna M.

AU - Lawrie, Stephen M.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Multicentre MRI studies offer great potential to increase Study power and flexibility, but it is not yet clear how reproducible the results from multiple centres may be. Here we present results from the multicentre Study 'CaliBrain', examining the reproducibility of fMRI data within and between three sites. Fourteen Subjects were scanned twice on three 1.5 T GE scanners using an identical scanning protocol. We present data from a motor task with three conditions, sequential and random finger tapping and rest. Similar activation maps were obtained for each site and visit; brain areas consistently activated during the task included the premotor, primary motor and supplementary motor areas, the striatum and cerebellum. Reproducibility was evaluated within and between sites by comparing the extent and spatial agreement of activation maps at both the subject and group levels. The results were within the range previously reported for similar tasks on single scanners and both measures were found to be comparable within and between sites, with between site reproducibility similar to the within site measures. A variance components analysis was used to examine the effects of site, subject and visit. The contributions of site and visit were small and reproducibility was similar between and within sites, whereas the variance between subjects, and unexplained variance was large. These findings suggest that we can have confidence in combined results from multicentre fMRI studies, at least when a consistent protocol is followed on similar machines in all participating scanning sites and care is taken to select homogeneous subject groups. (C) 2009 Elsevier Inc. All rights reserved.

AB - Multicentre MRI studies offer great potential to increase Study power and flexibility, but it is not yet clear how reproducible the results from multiple centres may be. Here we present results from the multicentre Study 'CaliBrain', examining the reproducibility of fMRI data within and between three sites. Fourteen Subjects were scanned twice on three 1.5 T GE scanners using an identical scanning protocol. We present data from a motor task with three conditions, sequential and random finger tapping and rest. Similar activation maps were obtained for each site and visit; brain areas consistently activated during the task included the premotor, primary motor and supplementary motor areas, the striatum and cerebellum. Reproducibility was evaluated within and between sites by comparing the extent and spatial agreement of activation maps at both the subject and group levels. The results were within the range previously reported for similar tasks on single scanners and both measures were found to be comparable within and between sites, with between site reproducibility similar to the within site measures. A variance components analysis was used to examine the effects of site, subject and visit. The contributions of site and visit were small and reproducibility was similar between and within sites, whereas the variance between subjects, and unexplained variance was large. These findings suggest that we can have confidence in combined results from multicentre fMRI studies, at least when a consistent protocol is followed on similar machines in all participating scanning sites and care is taken to select homogeneous subject groups. (C) 2009 Elsevier Inc. All rights reserved.

KW - fMRI

KW - CaliBrain

KW - Multicentre

KW - Scanner harmonisation

KW - Motor

KW - Reproducibility

KW - Test-Retest reliability

KW - Intrasubjct reproductibility

KW - Signal change

KW - Motor task

KW - MR systems

KW - Activation

KW - Precision

KW - multicentre

KW - scanner harmonisation

KW - motor

KW - reproductibility

U2 - 10.1016/j.neuroimage.2009.07.026

DO - 10.1016/j.neuroimage.2009.07.026

M3 - Article

VL - 49

SP - 552

EP - 560

JO - Neuroimage

JF - Neuroimage

SN - 1053-8119

IS - 1

ER -