Gastric fundic gland polyps in south-east Scotland

Alan G. Shand, Andrew C. Taylor, Mala Banerjee, Alastair Lessels, John Coia, Caroline Clark, Neva Elizabeth Haites, Subrata Ghosh

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

BACKGROUND AND AIM: Fundic gland polyps (FGP) were originally described in association with familial polyposis syndromes, but it is now accepted that the majority of FGP are picked up incidentally in up to 1.9% of routine endoscopies in dyspeptic patients. The familial adenomatous polyposis phenotype arises from germline mutations of the adenomatous polyposis coli (APC) gene. We aimed to see if there was any association between the presence of FGP, Helicobacter pylori, and two common APC gene mutations. METHODS: From a search of histopathology records in our unit, 85 consecutive patients were identified with a definite histological diagnosis of FGP between 1989 and 1997. Case notes could be retrieved in 48 cases to show the indication for endoscopy and endoscopic findings. Twenty-six patients (mean age 61 years, range 40-83 years) were tested for H. pylori status, and for the 1306 and 1061 bp deletions of the APC gene by the use of an enzyme-linked immunoassay and polymerase chain reaction techniques, respectively. RESULTS: Eighty-nine percent of patients underwent an endoscopy because of dyspepsia; 4.2% were anaemic, 4.2% had hematemesis and 1.2% had dysphagia. Only one patient was seropositive for H. pylori and no patient carried either APC gene deletion. CONCLUSIONS: This genetic information on those with FGP confirms previous phenotypic studies in that the majority of FGP are not associated with familial polyposis syndromes. The significance of such a strikingly low incidence of H. pylori infection in a dyspeptic population remains unclear.
Original languageEnglish
Pages (from-to)1161-1164
Number of pages4
JournalJournal of Gastroenterology and Hepatology
Volume17
Issue number11
Early online date1 Oct 2002
DOIs
Publication statusPublished - 1 Nov 2002

Fingerprint

Scotland
Polyps
Gastric Mucosa
APC Genes
Helicobacter pylori
Adenomatous Polyposis Coli
Endoscopy
Hematemesis
Germ-Line Mutation
Dyspepsia
Gene Deletion
Helicobacter Infections
Deglutition Disorders
Immunoenzyme Techniques
Phenotype
Polymerase Chain Reaction
Mutation
Incidence
Population

Keywords

  • Adenomatous Polyposis Coli
  • Adult
  • Aged
  • Aged, 80 and over
  • DNA Mutational Analysis
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Gastric Fundus
  • Gastric Mucosa
  • Genes, APC
  • Germ-Line Mutation
  • Helicobacter Infections
  • Helicobacter pylori
  • Humans
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Polyps
  • Prevalence
  • Retrospective Studies
  • Scotland
  • Stomach Neoplasms
  • familial adenomatous
  • fundic gland polyps
  • polyposis

Cite this

Shand, A. G., Taylor, A. C., Banerjee, M., Lessels, A., Coia, J., Clark, C., ... Ghosh, S. (2002). Gastric fundic gland polyps in south-east Scotland. Journal of Gastroenterology and Hepatology, 17(11), 1161-1164. https://doi.org/10.1046/j.1440-1746.2002.02863.x

Gastric fundic gland polyps in south-east Scotland. / Shand, Alan G.; Taylor, Andrew C. ; Banerjee, Mala; Lessels, Alastair; Coia, John; Clark, Caroline; Haites, Neva Elizabeth; Ghosh, Subrata.

In: Journal of Gastroenterology and Hepatology, Vol. 17, No. 11, 01.11.2002, p. 1161-1164.

Research output: Contribution to journalArticle

Shand, AG, Taylor, AC, Banerjee, M, Lessels, A, Coia, J, Clark, C, Haites, NE & Ghosh, S 2002, 'Gastric fundic gland polyps in south-east Scotland', Journal of Gastroenterology and Hepatology, vol. 17, no. 11, pp. 1161-1164. https://doi.org/10.1046/j.1440-1746.2002.02863.x
Shand AG, Taylor AC, Banerjee M, Lessels A, Coia J, Clark C et al. Gastric fundic gland polyps in south-east Scotland. Journal of Gastroenterology and Hepatology. 2002 Nov 1;17(11):1161-1164. https://doi.org/10.1046/j.1440-1746.2002.02863.x
Shand, Alan G. ; Taylor, Andrew C. ; Banerjee, Mala ; Lessels, Alastair ; Coia, John ; Clark, Caroline ; Haites, Neva Elizabeth ; Ghosh, Subrata. / Gastric fundic gland polyps in south-east Scotland. In: Journal of Gastroenterology and Hepatology. 2002 ; Vol. 17, No. 11. pp. 1161-1164.
@article{533f6cdde4814affa28b250f1a2b665a,
title = "Gastric fundic gland polyps in south-east Scotland",
abstract = "BACKGROUND AND AIM: Fundic gland polyps (FGP) were originally described in association with familial polyposis syndromes, but it is now accepted that the majority of FGP are picked up incidentally in up to 1.9{\%} of routine endoscopies in dyspeptic patients. The familial adenomatous polyposis phenotype arises from germline mutations of the adenomatous polyposis coli (APC) gene. We aimed to see if there was any association between the presence of FGP, Helicobacter pylori, and two common APC gene mutations. METHODS: From a search of histopathology records in our unit, 85 consecutive patients were identified with a definite histological diagnosis of FGP between 1989 and 1997. Case notes could be retrieved in 48 cases to show the indication for endoscopy and endoscopic findings. Twenty-six patients (mean age 61 years, range 40-83 years) were tested for H. pylori status, and for the 1306 and 1061 bp deletions of the APC gene by the use of an enzyme-linked immunoassay and polymerase chain reaction techniques, respectively. RESULTS: Eighty-nine percent of patients underwent an endoscopy because of dyspepsia; 4.2{\%} were anaemic, 4.2{\%} had hematemesis and 1.2{\%} had dysphagia. Only one patient was seropositive for H. pylori and no patient carried either APC gene deletion. CONCLUSIONS: This genetic information on those with FGP confirms previous phenotypic studies in that the majority of FGP are not associated with familial polyposis syndromes. The significance of such a strikingly low incidence of H. pylori infection in a dyspeptic population remains unclear.",
keywords = "Adenomatous Polyposis Coli, Adult, Aged, Aged, 80 and over, DNA Mutational Analysis, Enzyme-Linked Immunosorbent Assay, Female, Gastric Fundus, Gastric Mucosa, Genes, APC, Germ-Line Mutation, Helicobacter Infections, Helicobacter pylori, Humans, Male, Middle Aged, Polymerase Chain Reaction, Polyps, Prevalence, Retrospective Studies, Scotland, Stomach Neoplasms, familial adenomatous , fundic gland polyps, polyposis",
author = "Shand, {Alan G.} and Taylor, {Andrew C.} and Mala Banerjee and Alastair Lessels and John Coia and Caroline Clark and Haites, {Neva Elizabeth} and Subrata Ghosh",
note = "Copyright 2002 Blackwell Publishing Asia Pty Ltd",
year = "2002",
month = "11",
day = "1",
doi = "10.1046/j.1440-1746.2002.02863.x",
language = "English",
volume = "17",
pages = "1161--1164",
journal = "Journal of Gastroenterology and Hepatology",
issn = "0815-9319",
publisher = "Wiley-Blackwell",
number = "11",

}

TY - JOUR

T1 - Gastric fundic gland polyps in south-east Scotland

AU - Shand, Alan G.

AU - Taylor, Andrew C.

AU - Banerjee, Mala

AU - Lessels, Alastair

AU - Coia, John

AU - Clark, Caroline

AU - Haites, Neva Elizabeth

AU - Ghosh, Subrata

N1 - Copyright 2002 Blackwell Publishing Asia Pty Ltd

PY - 2002/11/1

Y1 - 2002/11/1

N2 - BACKGROUND AND AIM: Fundic gland polyps (FGP) were originally described in association with familial polyposis syndromes, but it is now accepted that the majority of FGP are picked up incidentally in up to 1.9% of routine endoscopies in dyspeptic patients. The familial adenomatous polyposis phenotype arises from germline mutations of the adenomatous polyposis coli (APC) gene. We aimed to see if there was any association between the presence of FGP, Helicobacter pylori, and two common APC gene mutations. METHODS: From a search of histopathology records in our unit, 85 consecutive patients were identified with a definite histological diagnosis of FGP between 1989 and 1997. Case notes could be retrieved in 48 cases to show the indication for endoscopy and endoscopic findings. Twenty-six patients (mean age 61 years, range 40-83 years) were tested for H. pylori status, and for the 1306 and 1061 bp deletions of the APC gene by the use of an enzyme-linked immunoassay and polymerase chain reaction techniques, respectively. RESULTS: Eighty-nine percent of patients underwent an endoscopy because of dyspepsia; 4.2% were anaemic, 4.2% had hematemesis and 1.2% had dysphagia. Only one patient was seropositive for H. pylori and no patient carried either APC gene deletion. CONCLUSIONS: This genetic information on those with FGP confirms previous phenotypic studies in that the majority of FGP are not associated with familial polyposis syndromes. The significance of such a strikingly low incidence of H. pylori infection in a dyspeptic population remains unclear.

AB - BACKGROUND AND AIM: Fundic gland polyps (FGP) were originally described in association with familial polyposis syndromes, but it is now accepted that the majority of FGP are picked up incidentally in up to 1.9% of routine endoscopies in dyspeptic patients. The familial adenomatous polyposis phenotype arises from germline mutations of the adenomatous polyposis coli (APC) gene. We aimed to see if there was any association between the presence of FGP, Helicobacter pylori, and two common APC gene mutations. METHODS: From a search of histopathology records in our unit, 85 consecutive patients were identified with a definite histological diagnosis of FGP between 1989 and 1997. Case notes could be retrieved in 48 cases to show the indication for endoscopy and endoscopic findings. Twenty-six patients (mean age 61 years, range 40-83 years) were tested for H. pylori status, and for the 1306 and 1061 bp deletions of the APC gene by the use of an enzyme-linked immunoassay and polymerase chain reaction techniques, respectively. RESULTS: Eighty-nine percent of patients underwent an endoscopy because of dyspepsia; 4.2% were anaemic, 4.2% had hematemesis and 1.2% had dysphagia. Only one patient was seropositive for H. pylori and no patient carried either APC gene deletion. CONCLUSIONS: This genetic information on those with FGP confirms previous phenotypic studies in that the majority of FGP are not associated with familial polyposis syndromes. The significance of such a strikingly low incidence of H. pylori infection in a dyspeptic population remains unclear.

KW - Adenomatous Polyposis Coli

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - DNA Mutational Analysis

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Gastric Fundus

KW - Gastric Mucosa

KW - Genes, APC

KW - Germ-Line Mutation

KW - Helicobacter Infections

KW - Helicobacter pylori

KW - Humans

KW - Male

KW - Middle Aged

KW - Polymerase Chain Reaction

KW - Polyps

KW - Prevalence

KW - Retrospective Studies

KW - Scotland

KW - Stomach Neoplasms

KW - familial adenomatous

KW - fundic gland polyps

KW - polyposis

U2 - 10.1046/j.1440-1746.2002.02863.x

DO - 10.1046/j.1440-1746.2002.02863.x

M3 - Article

C2 - 12453274

VL - 17

SP - 1161

EP - 1164

JO - Journal of Gastroenterology and Hepatology

JF - Journal of Gastroenterology and Hepatology

SN - 0815-9319

IS - 11

ER -