Generating cell surface diversity in Candida albicans and other fungal pathogens

Kerstin Nather, Carol A. Munro

Research output: Contribution to journalLiterature review

39 Citations (Scopus)

Abstract

The fungal cell surface contributes to pathogenesis by mediating interactions with host cells and eliciting host immune responses. This review focuses on the cell wall proteome of the major fungal pathogen Candida albicans and discusses how diversity at the cell surface can be introduced by altering the expression and structure of cell wall proteins. Remodelling the cell wall architecture is critical to maintain cellular integrity in response to different environments and stresses including challenge with antifungal drugs. In addition, the dynamic nature of the cell surface alters the physical properties of the fungal interface with host cells and thereby influences adhesion to the host and recognition by components of the host's immune system. Examples of the role of cell surface diversity in the pathogenesis of a number of microorganisms are described.

Original languageEnglish
Pages (from-to)137-145
Number of pages9
JournalFEMS Microbiology Letters
Volume285
Issue number2
Early online date9 Jul 2008
DOIs
Publication statusPublished - Aug 2008

Keywords

  • Candida albicans
  • cell wall proteins
  • tandem repeat
  • glycosylphosphatidyl inositol anchors
  • GPI-anchored proteins
  • coding tandem repeats
  • ALS gene family
  • saccharomyces-cerevisiae
  • histoplasma-capsulatum
  • antigenic variation
  • genome-wide
  • transcriptional regulation
  • blastomyces-dermatitidis
  • coccidioides-immitis

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