Ghrelin, Lipid Metabolism, and Metabolic Syndrome

Pablo Blanco Martinez de Morentin, Sulay Tovar, Ruben Nogueiras, Miguel Lopez, Carlos Diéguez

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Fatty acids, which play a crucial role in the metabolic syndrome, are essential mediators for the actions of ghrelin on both food intake and adiposity. This chapter summarizes the current knowledge about ghrelin actions and signaling pathways on metabolic homeostasis and energy balance with special emphasis on those related to its effects at hypothalamic level. Ghrelin, a hormone mainly produced in the stomach with orexigenic properties, has attracted great attention as a potential antiobesity therapeutic target. Chronic ghrelin administration promotes weight gain and adiposity in rodents, as well as increasing voluntary food‐intake in humans. In addition to its role as main modulator of hypothalamic lipid metabolism, recent data have also highlighted the role of ghrelin as a main modulator of peripheral lipid metabolism.
Original languageEnglish
Title of host publicationMetabolic Syndrome and Neurological Disorders
EditorsAkhlaq A. Farooqui, Tahira Farooqui
PublisherWiley-Blackwell
Pages475-484
Number of pages10
ISBN (Electronic)9781118395288
ISBN (Print)9781118395271
DOIs
Publication statusPublished - 15 Nov 2013

Fingerprint

Ghrelin
Lipid Metabolism
Adiposity
Metabolic Networks and Pathways
Weight Gain
Rodentia
Stomach
Homeostasis
Fatty Acids
Eating
Hormones

Keywords

  • energy balance
  • food intake
  • ghrelin
  • lipid metabolism
  • metabolic syndrome

Cite this

Blanco Martinez de Morentin, P., Tovar, S., Nogueiras, R., Lopez, M., & Diéguez, C. (2013). Ghrelin, Lipid Metabolism, and Metabolic Syndrome. In A. A. Farooqui, & T. Farooqui (Eds.), Metabolic Syndrome and Neurological Disorders (pp. 475-484). [29] Wiley-Blackwell . https://doi.org/10.1002/9781118395318.ch29

Ghrelin, Lipid Metabolism, and Metabolic Syndrome. / Blanco Martinez de Morentin, Pablo; Tovar, Sulay; Nogueiras, Ruben; Lopez, Miguel; Diéguez, Carlos.

Metabolic Syndrome and Neurological Disorders. ed. / Akhlaq A. Farooqui; Tahira Farooqui. Wiley-Blackwell , 2013. p. 475-484 29.

Research output: Chapter in Book/Report/Conference proceedingChapter

Blanco Martinez de Morentin, P, Tovar, S, Nogueiras, R, Lopez, M & Diéguez, C 2013, Ghrelin, Lipid Metabolism, and Metabolic Syndrome. in AA Farooqui & T Farooqui (eds), Metabolic Syndrome and Neurological Disorders., 29, Wiley-Blackwell , pp. 475-484. https://doi.org/10.1002/9781118395318.ch29
Blanco Martinez de Morentin P, Tovar S, Nogueiras R, Lopez M, Diéguez C. Ghrelin, Lipid Metabolism, and Metabolic Syndrome. In Farooqui AA, Farooqui T, editors, Metabolic Syndrome and Neurological Disorders. Wiley-Blackwell . 2013. p. 475-484. 29 https://doi.org/10.1002/9781118395318.ch29
Blanco Martinez de Morentin, Pablo ; Tovar, Sulay ; Nogueiras, Ruben ; Lopez, Miguel ; Diéguez, Carlos. / Ghrelin, Lipid Metabolism, and Metabolic Syndrome. Metabolic Syndrome and Neurological Disorders. editor / Akhlaq A. Farooqui ; Tahira Farooqui. Wiley-Blackwell , 2013. pp. 475-484
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