Global functional connectivity reveals highly significant differences between the vegetative and the minimally conscious state

Boris Kotchoubey, Susanne Merz, Simone Lang, Alexandra Markl, Friedemann Müller, Tao Yu, Christian Schwarzbauer (Corresponding Author)

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

A major challenge in the diagnosis of disorders of consciousness is the differential diagnosis between the vegetative state (VS) and the minimally conscious state (MCS). Clinically, VS is defined by complete unawareness, whereas MCS is defined by the presence of inconsistent but clearly discernible behavioural signs of consciousness. In healthy individuals, pain cries have been reported to elicit functional activation within the pain matrix of the brain, which may be interpreted as empathic reaction. In this study, pain cries were presented to six VS patients, six MCS patients, and 17 age-matched healthy controls. Conventional task-related functional magnetic resonance imaging (fMRI) showed no significant differences in functional activation between the VS and MCS groups. In contrast to this negative finding, the application of a novel data-driven technique for the analysis of the brain’s global functional connectivity yielded a positive result. The weighted global connectivity (WGC) was significantly greater in the MCS group compared to the VS group (p < 0.05, family-wise error corrected). Using areas of significant WGC differences as ‘seed regions’ in a secondary connectivity analysis revealed extended functional networks in both MCS and healthy groups, whereas no such long-range functional connections were observed in the VS group. These results demonstrate the potential of functional connectivity MRI (fcMRI) as a clinical tool for differential diagnosis in disorders of consciousness.
Original languageEnglish
Pages (from-to)975-983
Number of pages9
JournalJournal of Neurology
Volume260
Issue number4
Early online date6 Nov 2012
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Persistent Vegetative State
Consciousness Disorders
Pain
Differential Diagnosis
Magnetic Resonance Imaging
Brain
Consciousness
Seeds

Keywords

  • traumatic brain injury
  • anoxic brain injury
  • coma
  • consciousness
  • functional connectivity
  • unresponsive wakefulness syndrome

Cite this

Global functional connectivity reveals highly significant differences between the vegetative and the minimally conscious state. / Kotchoubey, Boris; Merz, Susanne; Lang, Simone; Markl, Alexandra; Müller, Friedemann; Yu, Tao; Schwarzbauer, Christian (Corresponding Author).

In: Journal of Neurology, Vol. 260, No. 4, 04.2013, p. 975-983.

Research output: Contribution to journalArticle

Kotchoubey, Boris ; Merz, Susanne ; Lang, Simone ; Markl, Alexandra ; Müller, Friedemann ; Yu, Tao ; Schwarzbauer, Christian. / Global functional connectivity reveals highly significant differences between the vegetative and the minimally conscious state. In: Journal of Neurology. 2013 ; Vol. 260, No. 4. pp. 975-983.
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