HDAC9 is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells

Bing Lang, Tahani Mohammed A Alrahbeni, David St Clair, Douglas H. Blackwood, Colin Darnley McCaig, Sanbing Shen

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Schizophrenia is a common psychiatric disorder and caused by a combination of environmental, social and genetic factors. Histone deacetylases (HDACs) can translate epigenetic effects to the genome by modifying chromatin
structure and gene expression. Inappropriate activity of HDACs is associated with cancer, cardiovascular and neurological diseases, and HDAC inhibitors are shown to improve the derivation of induced pluripotent stem (iPS) cells and
to modulate cell lineage differentiation during brain development. We demonstrate that one of the HDAC genes, HDAC9, is hemizygously deleted in a small proportion of schizophrenia patients, and is widely expressed in mouse
brain including areas where the neuropathology of schizophrenia is found. High levels of expression are observed in the hippocampus, layers II/III and V of the cerebral cortex, prefrontal and medial prefrontal cortex, piriform and cingulum
cortex, basolateral amygdaloid nuclei and choroid plexus. HDAC9 protein is found in the cell body as well as in nerve fibers. Importantly, HDAC9 is not expressed in adult neural stem cells, glia, astrocytes, or oligodendrocytes, but
expressed exclusively in post-mitotic and mature neurons. Our data suggest that HDAC9 may play a crucial role in neuronal function of adult brain.
Original languageEnglish
Pages (from-to)31-41
Number of pages10
JournalAmerican Journal of Stem Cells
Volume1
Issue number1
Early online date18 Aug 2011
Publication statusPublished - 1 Jan 2012

Keywords

  • adult neural stem cells
  • copy number variation
  • HDAC9
  • histone deacetylase
  • neuron-specific expression
  • schizophrenia

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