HDAC9 is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells

Bing Lang, Tahani Mohammed A Alrahbeni, David St Clair, Douglas H. Blackwood, Colin Darnley McCaig, Sanbing Shen

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Schizophrenia is a common psychiatric disorder and caused by a combination of environmental, social and genetic factors. Histone deacetylases (HDACs) can translate epigenetic effects to the genome by modifying chromatin
structure and gene expression. Inappropriate activity of HDACs is associated with cancer, cardiovascular and neurological diseases, and HDAC inhibitors are shown to improve the derivation of induced pluripotent stem (iPS) cells and
to modulate cell lineage differentiation during brain development. We demonstrate that one of the HDAC genes, HDAC9, is hemizygously deleted in a small proportion of schizophrenia patients, and is widely expressed in mouse
brain including areas where the neuropathology of schizophrenia is found. High levels of expression are observed in the hippocampus, layers II/III and V of the cerebral cortex, prefrontal and medial prefrontal cortex, piriform and cingulum
cortex, basolateral amygdaloid nuclei and choroid plexus. HDAC9 protein is found in the cell body as well as in nerve fibers. Importantly, HDAC9 is not expressed in adult neural stem cells, glia, astrocytes, or oligodendrocytes, but
expressed exclusively in post-mitotic and mature neurons. Our data suggest that HDAC9 may play a crucial role in neuronal function of adult brain.
Original languageEnglish
Pages (from-to)31-41
Number of pages10
JournalAmerican Journal of Stem Cells
Volume1
Issue number1
Early online date18 Aug 2011
Publication statusPublished - 1 Jan 2012

Fingerprint

Adult Stem Cells
Histone Deacetylases
Neural Stem Cells
Schizophrenia
Neurons
Induced Pluripotent Stem Cells
Choroid Plexus
Oligodendroglia
Brain
Cell Lineage
Amygdala
Prefrontal Cortex
Nerve Fibers
Epigenomics
Neuroglia
Astrocytes
Cerebral Cortex
Psychiatry
Cell Differentiation
Hippocampus

Keywords

  • adult neural stem cells
  • copy number variation
  • HDAC9
  • histone deacetylase
  • neuron-specific expression
  • schizophrenia

Cite this

HDAC9 is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells. / Lang, Bing; Alrahbeni, Tahani Mohammed A; St Clair, David; Blackwood, Douglas H.; McCaig, Colin Darnley; Shen, Sanbing.

In: American Journal of Stem Cells, Vol. 1, No. 1, 01.01.2012, p. 31-41.

Research output: Contribution to journalArticle

@article{81a9e77fe60449f69bfc238c8e8e074e,
title = "HDAC9 is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells",
abstract = "Schizophrenia is a common psychiatric disorder and caused by a combination of environmental, social and genetic factors. Histone deacetylases (HDACs) can translate epigenetic effects to the genome by modifying chromatin structure and gene expression. Inappropriate activity of HDACs is associated with cancer, cardiovascular and neurological diseases, and HDAC inhibitors are shown to improve the derivation of induced pluripotent stem (iPS) cells and to modulate cell lineage differentiation during brain development. We demonstrate that one of the HDAC genes, HDAC9, is hemizygously deleted in a small proportion of schizophrenia patients, and is widely expressed in mouse brain including areas where the neuropathology of schizophrenia is found. High levels of expression are observed in the hippocampus, layers II/III and V of the cerebral cortex, prefrontal and medial prefrontal cortex, piriform and cingulum cortex, basolateral amygdaloid nuclei and choroid plexus. HDAC9 protein is found in the cell body as well as in nerve fibers. Importantly, HDAC9 is not expressed in adult neural stem cells, glia, astrocytes, or oligodendrocytes, but expressed exclusively in post-mitotic and mature neurons. Our data suggest that HDAC9 may play a crucial role in neuronal function of adult brain.",
keywords = "adult neural stem cells, copy number variation, HDAC9, histone deacetylase, neuron-specific expression, schizophrenia",
author = "Bing Lang and Alrahbeni, {Tahani Mohammed A} and {St Clair}, David and Blackwood, {Douglas H.} and McCaig, {Colin Darnley} and Sanbing Shen",
year = "2012",
month = "1",
day = "1",
language = "English",
volume = "1",
pages = "31--41",
journal = "American Journal of Stem Cells",
issn = "2160-4150",
publisher = "e-Century Publishing Corporation",
number = "1",

}

TY - JOUR

T1 - HDAC9 is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells

AU - Lang, Bing

AU - Alrahbeni, Tahani Mohammed A

AU - St Clair, David

AU - Blackwood, Douglas H.

AU - McCaig, Colin Darnley

AU - Shen, Sanbing

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Schizophrenia is a common psychiatric disorder and caused by a combination of environmental, social and genetic factors. Histone deacetylases (HDACs) can translate epigenetic effects to the genome by modifying chromatin structure and gene expression. Inappropriate activity of HDACs is associated with cancer, cardiovascular and neurological diseases, and HDAC inhibitors are shown to improve the derivation of induced pluripotent stem (iPS) cells and to modulate cell lineage differentiation during brain development. We demonstrate that one of the HDAC genes, HDAC9, is hemizygously deleted in a small proportion of schizophrenia patients, and is widely expressed in mouse brain including areas where the neuropathology of schizophrenia is found. High levels of expression are observed in the hippocampus, layers II/III and V of the cerebral cortex, prefrontal and medial prefrontal cortex, piriform and cingulum cortex, basolateral amygdaloid nuclei and choroid plexus. HDAC9 protein is found in the cell body as well as in nerve fibers. Importantly, HDAC9 is not expressed in adult neural stem cells, glia, astrocytes, or oligodendrocytes, but expressed exclusively in post-mitotic and mature neurons. Our data suggest that HDAC9 may play a crucial role in neuronal function of adult brain.

AB - Schizophrenia is a common psychiatric disorder and caused by a combination of environmental, social and genetic factors. Histone deacetylases (HDACs) can translate epigenetic effects to the genome by modifying chromatin structure and gene expression. Inappropriate activity of HDACs is associated with cancer, cardiovascular and neurological diseases, and HDAC inhibitors are shown to improve the derivation of induced pluripotent stem (iPS) cells and to modulate cell lineage differentiation during brain development. We demonstrate that one of the HDAC genes, HDAC9, is hemizygously deleted in a small proportion of schizophrenia patients, and is widely expressed in mouse brain including areas where the neuropathology of schizophrenia is found. High levels of expression are observed in the hippocampus, layers II/III and V of the cerebral cortex, prefrontal and medial prefrontal cortex, piriform and cingulum cortex, basolateral amygdaloid nuclei and choroid plexus. HDAC9 protein is found in the cell body as well as in nerve fibers. Importantly, HDAC9 is not expressed in adult neural stem cells, glia, astrocytes, or oligodendrocytes, but expressed exclusively in post-mitotic and mature neurons. Our data suggest that HDAC9 may play a crucial role in neuronal function of adult brain.

KW - adult neural stem cells

KW - copy number variation

KW - HDAC9

KW - histone deacetylase

KW - neuron-specific expression

KW - schizophrenia

M3 - Article

VL - 1

SP - 31

EP - 41

JO - American Journal of Stem Cells

JF - American Journal of Stem Cells

SN - 2160-4150

IS - 1

ER -