High-risk HPV genotyping in the follow-up of women treated conservatively for microinvasive cervical cancer

Mary Cairns; Kate S. Cuschieri; Heather A. Cubie; Margaret E. Cruickshank

doi:10.1111/IGC.0b013e3181c3a6b6

High-risk HPV genotyping in the follow-up of women treated conservatively for microinvasive cervical cancer

Mary Cairns, Kate S. Cuschieri, Heather A. Cubie, Margaret E. Cruickshank

Medical Education

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Objectives: Conservative management of women with microinvasive cervical cancer (International Federation of Gynecologists and Obstetricians stage IA) has led to prolonged and intensive cytological follow-up. We conducted a retrospective study to assess human papillomavirus status and genotypes at diagnosis and to find out whether there is an association between the persistence of high-risk human papillomavirus during follow-up and the detection of recurrent disease.

Study Design: Paraffin-embedded cervical biopsies in the pathology archives were identified from women with an initial large loop excision of the transformation zone or cone specimen diagnostic of microinvasive disease since 1991.

Results: We identified 45 women with a diagnosis of microinvasive cervical cancer. Human papillomavirus was detected in 87% of the initial diagnostic specimens. Human papillomavirus testing showed a negative predictive value of 100% for recurrent disease with a sensitivity of 100%.

Conclusion: Human papillomavirus testing has an important role in the follow-up of women treated conservatively for stage IA cervical cancer.

Original language	English
Pages (from-to)	154-157
Number of pages	4
Journal	International Journal of Gynecological Cancer
Volume	20
Issue number	1
DOIs	https://doi.org/10.1111/IGC.0b013e3181c3a6b6
Publication status	Published - Jan 2010

Keywords

human papillomavirus (HPV)
microinvasive cervical cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/IGC.0b013e3181c3a6b6

Cite this

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title = "High-risk HPV genotyping in the follow-up of women treated conservatively for microinvasive cervical cancer",

abstract = "Objectives: Conservative management of women with microinvasive cervical cancer (International Federation of Gynecologists and Obstetricians stage IA) has led to prolonged and intensive cytological follow-up. We conducted a retrospective study to assess human papillomavirus status and genotypes at diagnosis and to find out whether there is an association between the persistence of high-risk human papillomavirus during follow-up and the detection of recurrent disease. Study Design: Paraffin-embedded cervical biopsies in the pathology archives were identified from women with an initial large loop excision of the transformation zone or cone specimen diagnostic of microinvasive disease since 1991. Results: We identified 45 women with a diagnosis of microinvasive cervical cancer. Human papillomavirus was detected in 87% of the initial diagnostic specimens. Human papillomavirus testing showed a negative predictive value of 100% for recurrent disease with a sensitivity of 100%. Conclusion: Human papillomavirus testing has an important role in the follow-up of women treated conservatively for stage IA cervical cancer.",

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AU - Cuschieri, Kate S.

AU - Cubie, Heather A.

AU - Cruickshank, Margaret E.

PY - 2010/1

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N2 - Objectives: Conservative management of women with microinvasive cervical cancer (International Federation of Gynecologists and Obstetricians stage IA) has led to prolonged and intensive cytological follow-up. We conducted a retrospective study to assess human papillomavirus status and genotypes at diagnosis and to find out whether there is an association between the persistence of high-risk human papillomavirus during follow-up and the detection of recurrent disease. Study Design: Paraffin-embedded cervical biopsies in the pathology archives were identified from women with an initial large loop excision of the transformation zone or cone specimen diagnostic of microinvasive disease since 1991. Results: We identified 45 women with a diagnosis of microinvasive cervical cancer. Human papillomavirus was detected in 87% of the initial diagnostic specimens. Human papillomavirus testing showed a negative predictive value of 100% for recurrent disease with a sensitivity of 100%. Conclusion: Human papillomavirus testing has an important role in the follow-up of women treated conservatively for stage IA cervical cancer.

AB - Objectives: Conservative management of women with microinvasive cervical cancer (International Federation of Gynecologists and Obstetricians stage IA) has led to prolonged and intensive cytological follow-up. We conducted a retrospective study to assess human papillomavirus status and genotypes at diagnosis and to find out whether there is an association between the persistence of high-risk human papillomavirus during follow-up and the detection of recurrent disease. Study Design: Paraffin-embedded cervical biopsies in the pathology archives were identified from women with an initial large loop excision of the transformation zone or cone specimen diagnostic of microinvasive disease since 1991. Results: We identified 45 women with a diagnosis of microinvasive cervical cancer. Human papillomavirus was detected in 87% of the initial diagnostic specimens. Human papillomavirus testing showed a negative predictive value of 100% for recurrent disease with a sensitivity of 100%. Conclusion: Human papillomavirus testing has an important role in the follow-up of women treated conservatively for stage IA cervical cancer.

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High-risk HPV genotyping in the follow-up of women treated conservatively for microinvasive cervical cancer

Abstract

Keywords

UN SDGs

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