High risk of peripheral arterial disease in the United Kingdom

2 year results of a prospective registry

Gerry Stansby (Corresponding Author), R Mister , G Fowkes , M Roughton , J Brittenden, F Nugara , A Bradbury , C Shermann, R Hannon , M Flather

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We report a prospective 2-year, multicenter study of patients presenting with intermittent claudication (IC; ankle brachial blood pressure index, ABPI = 0.9). Mean age of the 473 patients enrolled was 68 years, 20% were diabetics, 30% had prior symptomatic coronary heart disease (CHD), 7% had prior stroke, and 39% were current smokers. At baseline, 26.2% of patients had BP = 140/85 mm Hg or lower and at 2 years this figure was 32.5% (P = .01). Current smokers had fallen to 27% (from 39%) at 2 years (P < .001). Use of antiplatelet agents, statins, and angiotensin converting enzyme inhibitors increased significantly during the course of the study as did claudication distance. Death and the composite of death, stroke or myocardial infarction (MI), occurred in 8.4% and 11.6% of patients, respectively. Prognosis was worse in patients with prior history of CHD, older age, those with diabetes and a lower ABPI.

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalAngiology
Volume62
Issue number2
DOIs
Publication statusPublished - Feb 2011

Fingerprint

Peripheral Arterial Disease
Registries
Coronary Disease
Stroke
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Intermittent Claudication
Platelet Aggregation Inhibitors
Angiotensin-Converting Enzyme Inhibitors
Ankle
Multicenter Studies
Arm
Myocardial Infarction
United Kingdom
Blood Pressure

Keywords

  • claudication
  • peripheral arterial disease
  • risk factors

Cite this

High risk of peripheral arterial disease in the United Kingdom : 2 year results of a prospective registry. / Stansby, Gerry (Corresponding Author); Mister , R; Fowkes , G; Roughton , M; Brittenden, J; Nugara , F; Bradbury , A; Shermann, C; Hannon , R; Flather , M.

In: Angiology, Vol. 62, No. 2, 02.2011, p. 111-118.

Research output: Contribution to journalArticle

Stansby, G, Mister , R, Fowkes , G, Roughton , M, Brittenden, J, Nugara , F, Bradbury , A, Shermann, C, Hannon , R & Flather , M 2011, 'High risk of peripheral arterial disease in the United Kingdom: 2 year results of a prospective registry', Angiology, vol. 62, no. 2, pp. 111-118. https://doi.org/10.1177/0003319710387917
Stansby, Gerry ; Mister , R ; Fowkes , G ; Roughton , M ; Brittenden, J ; Nugara , F ; Bradbury , A ; Shermann, C ; Hannon , R ; Flather , M. / High risk of peripheral arterial disease in the United Kingdom : 2 year results of a prospective registry. In: Angiology. 2011 ; Vol. 62, No. 2. pp. 111-118.
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