Histamine and antihistamines

Amr M. Mahdy, Nigel R. Webster

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Histamine is one of the most extensively studied biological amines in medicine. It stimulates smooth muscle contraction and gastric acid secretion, increases vascular permeability, functions as a neurotransmitter, and plays various roles in immunomodulation, allergy, inflammation, haematopoiesis and cell proliferation. Histamine exerts its effects through four receptors, designated H1-H4. H1 and H2 receptors are widely distributed, H3 receptors are mainly presynaptic, and H4 receptors are mainly haematopoietic. H1 antihistamines are classified as first- and second-generation compounds. First-generation compounds lack specificity and cross the blood-brain barrier causing sedation. Second-generation compounds are less sedating and highly specific. H1 antihistamines have well-documented anti-allergic and anti-inflammatory effects and are well established in the treatment of a variety of allergic disorders. First-generation antihistamines are also used in the treatment of vestibular disorders and can be used as sedatives, sleeping aids and anti-emetics. H2 antihistamines are widely used in the treatment of gastric acid-related disorders; however, proton pump inhibitors are becoming the drugs of first choice in some of these disorders. H3 antihistamines are expected to be of potential value in the treatment of some cognitive disorder. H4 antihistamines could be of potential therapeutic benefit in the management of various immune and inflammatory disorders.

Original languageEnglish
Pages (from-to)250-255
Number of pages6
JournalAnaesthesia and Intensive Care Medicine
Volume15
Issue number5
Early online date18 Apr 2014
DOIs
Publication statusPublished - May 2014

Fingerprint

Histamine Antagonists
Histamine
Histamine H1 Receptors
Gastric Acid
Histamine H3 Receptors
Presynaptic Receptors
Therapeutics
Anti-Allergic Agents
Histamine H2 Receptors
Antiemetics
Immunomodulation
Proton Pump Inhibitors
Immune System Diseases
Hematopoiesis
Capillary Permeability
Muscle Contraction
Blood-Brain Barrier
Hypnotics and Sedatives
Amines
Smooth Muscle

Keywords

  • Antihistamines
  • histamine
  • histamine receptors

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Histamine and antihistamines. / Mahdy, Amr M.; Webster, Nigel R.

In: Anaesthesia and Intensive Care Medicine, Vol. 15, No. 5, 05.2014, p. 250-255.

Research output: Contribution to journalArticle

Mahdy, Amr M. ; Webster, Nigel R. / Histamine and antihistamines. In: Anaesthesia and Intensive Care Medicine. 2014 ; Vol. 15, No. 5. pp. 250-255.
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