Host-parasite coevolutionary conflict between Arabidopsis and downy mildew

Rebecca Allen, Peter D Bittner-Eddy, Laura Joy Grenville-Briggs, Julia C Meitz, Anne P Rehmany, Laura Rose, Jim L Beynon

Research output: Contribution to journalArticle

315 Citations (Scopus)

Abstract

Plants are constantly exposed to attack by an array of diverse pathogens but lack a somatically adaptive immune system. In spite of this, natural plant populations do not often suffer destructive disease epidemics. Elucidating how allelic diversity within plant genes that function to detect pathogens (resistance genes) counteracts changing structures of pathogen genes required for host invasion (pathogenicity effectors) is critical to our understanding of the dynamics of natural plant populations. The RPP13 resistance gene is the most polymorphic gene analyzed to date in the model plant Arabidopsis thaliana. Here we report the cloning of the avirulence gene, ATR13, that triggers RPP13-mediated resistance, and we show that it too exhibits extreme levels of amino acid polymorphism. Evidence of diversifying selection visible in both components suggests that the host and pathogen may be locked in a coevolutionary conflict at these loci, where attempts to evade host resistance by the pathogen are matched by the development of new detection capabilities by the host.
Original languageEnglish
Pages (from-to)1957-1960
Number of pages4
JournalScience
Volume306
Issue number5703
DOIs
Publication statusPublished - 10 Dec 2004

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Arabidopsis
Parasites
Genes
Plant Genes
Population
Virulence
Organism Cloning
Immune System
Amino Acids

Keywords

  • amino acid sequence
  • Arabidopsis
  • arabidopsis proteins
  • biolistics
  • molecular cloning
  • evolution
  • fungal proteins
  • fungal genes
  • plant genes
  • molecular sequence data
  • oomycetes
  • plant diseases
  • genetic polymorphism
  • protein sorting signals
  • genetic selection
  • rice blast resistance
  • avirulence gene
  • Cladosporium fulvum
  • Peronospora parasitica
  • protein
  • Thaliana
  • elicitor
  • infection

Cite this

Allen, R., Bittner-Eddy, P. D., Grenville-Briggs, L. J., Meitz, J. C., Rehmany, A. P., Rose, L., & Beynon, J. L. (2004). Host-parasite coevolutionary conflict between Arabidopsis and downy mildew. Science, 306(5703), 1957-1960. https://doi.org/10.1126/science.1104022

Host-parasite coevolutionary conflict between Arabidopsis and downy mildew. / Allen, Rebecca; Bittner-Eddy, Peter D; Grenville-Briggs, Laura Joy; Meitz, Julia C; Rehmany, Anne P; Rose, Laura; Beynon, Jim L.

In: Science, Vol. 306, No. 5703, 10.12.2004, p. 1957-1960.

Research output: Contribution to journalArticle

Allen, R, Bittner-Eddy, PD, Grenville-Briggs, LJ, Meitz, JC, Rehmany, AP, Rose, L & Beynon, JL 2004, 'Host-parasite coevolutionary conflict between Arabidopsis and downy mildew', Science, vol. 306, no. 5703, pp. 1957-1960. https://doi.org/10.1126/science.1104022
Allen R, Bittner-Eddy PD, Grenville-Briggs LJ, Meitz JC, Rehmany AP, Rose L et al. Host-parasite coevolutionary conflict between Arabidopsis and downy mildew. Science. 2004 Dec 10;306(5703):1957-1960. https://doi.org/10.1126/science.1104022
Allen, Rebecca ; Bittner-Eddy, Peter D ; Grenville-Briggs, Laura Joy ; Meitz, Julia C ; Rehmany, Anne P ; Rose, Laura ; Beynon, Jim L. / Host-parasite coevolutionary conflict between Arabidopsis and downy mildew. In: Science. 2004 ; Vol. 306, No. 5703. pp. 1957-1960.
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