Hyperthyroidism differentially regulates neuropeptide S system in the rat brain

Carmen R González; Pablo B Martínez de Morentin; Noelia Martínez-Sánchez; Consuelo Gómez-Díaz; Ricardo Lage; Luis Varela; Carlos Diéguez; Rubén Nogueiras; Justo P Castaño; Miguel López

doi:10.1016/j.brainres.2012.02.024

Hyperthyroidism differentially regulates neuropeptide S system in the rat brain

Carmen R González, Pablo B Martínez de Morentin, Noelia Martínez-Sánchez, Consuelo Gómez-Díaz, Ricardo Lage, Luis Varela, Carlos Diéguez, Rubén Nogueiras, Justo P Castaño, Miguel López

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Thyroid hormones play an important role in the regulation of energy balance, sleep and emotional behaviors. Neuropeptide S (NPS) is a recently discovered neuropeptide, regulating feeding, sleep and anxiety. Here, we examined the effect of hyperthyroidism on the gene and protein expression of neuropeptide S and its receptor (NPS-R) in the hypothalamus, brainstem and amygdala of rats. Our results showed that the expression of NPS and NPS-R was differentially modulated by hyperthyroidism in the rat brain. NPS and NPS-R mRNA and protein levels were decreased in the hypothalamus of hyperthyroid rats. Conversely NPS-R expression was highly increased in the brainstem and NPS and NPS-R expression were unchanged in the amygdala of these rats. These data suggest that changes in anxiety and food intake patterns observed in hyperthyroidism could be associated with changes in the expression of NPS and NPS-R. Thus, the NPS/NPS-R system may be involved in several hyperthyroidism-associated comorbidities.

Original language	English
Pages (from-to)	40-48
Number of pages	9
Journal	Brain Research
Volume	1450
Early online date	18 Feb 2012
DOIs	https://doi.org/10.1016/j.brainres.2012.02.024
Publication status	Published - 23 Apr 2012

Bibliographical note

Acknowledgements
We sincerely thank to Dr. Andrew Whittle (University of Cambridge) for his comments, suggestions and criticism. The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 281854– the ObERStress project (ML), 245009– the Neurofast project (RN, CD and ML), and 223713 (CD, RN, ML), Fondo Investigationes Sanitarias (ML: PS09/01880), Ministerio de Educaciony Ciencia (RN: RyC-2008-02219; JPC: BFU2010-19300; ML: RyC-2007-00211), Junta de Andalucía (JPC: BIO-139 and CTS-5051),Ministerio de Ciencia e Innovación (RN: SAF2009-07049), and Xunta de Galicia (RN 2010/14 and ML: 10PXIB208164PR).CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative of ISCIII. Authors declare no conflict of interest.

Keywords

Amygdala
Animals
Brain Stem
Eating
Gene Expression
Hyperthyroidism
Hypothalamus
Male
Neuropeptides
Rats
Rats, Sprague-Dawley
Sleep

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title = "Hyperthyroidism differentially regulates neuropeptide S system in the rat brain",

abstract = "Thyroid hormones play an important role in the regulation of energy balance, sleep and emotional behaviors. Neuropeptide S (NPS) is a recently discovered neuropeptide, regulating feeding, sleep and anxiety. Here, we examined the effect of hyperthyroidism on the gene and protein expression of neuropeptide S and its receptor (NPS-R) in the hypothalamus, brainstem and amygdala of rats. Our results showed that the expression of NPS and NPS-R was differentially modulated by hyperthyroidism in the rat brain. NPS and NPS-R mRNA and protein levels were decreased in the hypothalamus of hyperthyroid rats. Conversely NPS-R expression was highly increased in the brainstem and NPS and NPS-R expression were unchanged in the amygdala of these rats. These data suggest that changes in anxiety and food intake patterns observed in hyperthyroidism could be associated with changes in the expression of NPS and NPS-R. Thus, the NPS/NPS-R system may be involved in several hyperthyroidism-associated comorbidities.",

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note = "Acknowledgements We sincerely thank to Dr. Andrew Whittle (University of Cambridge) for his comments, suggestions and criticism. The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 281854– the ObERStress project (ML), 245009– the Neurofast project (RN, CD and ML), and 223713 (CD, RN, ML), Fondo Investigationes Sanitarias (ML: PS09/01880), Ministerio de Educaciony Ciencia (RN: RyC-2008-02219; JPC: BFU2010-19300; ML: RyC-2007-00211), Junta de Andaluc{\'i}a (JPC: BIO-139 and CTS-5051),Ministerio de Ciencia e Innovaci{\'o}n (RN: SAF2009-07049), and Xunta de Galicia (RN 2010/14 and ML: 10PXIB208164PR).CIBER de Fisiopatolog{\'i}a de la Obesidad y Nutrici{\'o}n is an initiative of ISCIII. Authors declare no conflict of interest.",

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T1 - Hyperthyroidism differentially regulates neuropeptide S system in the rat brain

AU - González, Carmen R

AU - Martínez de Morentin, Pablo B

AU - Martínez-Sánchez, Noelia

AU - Gómez-Díaz, Consuelo

AU - Lage, Ricardo

AU - Varela, Luis

AU - Diéguez, Carlos

AU - Nogueiras, Rubén

AU - Castaño, Justo P

AU - López, Miguel

N1 - Acknowledgements We sincerely thank to Dr. Andrew Whittle (University of Cambridge) for his comments, suggestions and criticism. The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 281854– the ObERStress project (ML), 245009– the Neurofast project (RN, CD and ML), and 223713 (CD, RN, ML), Fondo Investigationes Sanitarias (ML: PS09/01880), Ministerio de Educaciony Ciencia (RN: RyC-2008-02219; JPC: BFU2010-19300; ML: RyC-2007-00211), Junta de Andalucía (JPC: BIO-139 and CTS-5051),Ministerio de Ciencia e Innovación (RN: SAF2009-07049), and Xunta de Galicia (RN 2010/14 and ML: 10PXIB208164PR).CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative of ISCIII. Authors declare no conflict of interest.

PY - 2012/4/23

Y1 - 2012/4/23

N2 - Thyroid hormones play an important role in the regulation of energy balance, sleep and emotional behaviors. Neuropeptide S (NPS) is a recently discovered neuropeptide, regulating feeding, sleep and anxiety. Here, we examined the effect of hyperthyroidism on the gene and protein expression of neuropeptide S and its receptor (NPS-R) in the hypothalamus, brainstem and amygdala of rats. Our results showed that the expression of NPS and NPS-R was differentially modulated by hyperthyroidism in the rat brain. NPS and NPS-R mRNA and protein levels were decreased in the hypothalamus of hyperthyroid rats. Conversely NPS-R expression was highly increased in the brainstem and NPS and NPS-R expression were unchanged in the amygdala of these rats. These data suggest that changes in anxiety and food intake patterns observed in hyperthyroidism could be associated with changes in the expression of NPS and NPS-R. Thus, the NPS/NPS-R system may be involved in several hyperthyroidism-associated comorbidities.

AB - Thyroid hormones play an important role in the regulation of energy balance, sleep and emotional behaviors. Neuropeptide S (NPS) is a recently discovered neuropeptide, regulating feeding, sleep and anxiety. Here, we examined the effect of hyperthyroidism on the gene and protein expression of neuropeptide S and its receptor (NPS-R) in the hypothalamus, brainstem and amygdala of rats. Our results showed that the expression of NPS and NPS-R was differentially modulated by hyperthyroidism in the rat brain. NPS and NPS-R mRNA and protein levels were decreased in the hypothalamus of hyperthyroid rats. Conversely NPS-R expression was highly increased in the brainstem and NPS and NPS-R expression were unchanged in the amygdala of these rats. These data suggest that changes in anxiety and food intake patterns observed in hyperthyroidism could be associated with changes in the expression of NPS and NPS-R. Thus, the NPS/NPS-R system may be involved in several hyperthyroidism-associated comorbidities.

KW - Amygdala

KW - Animals

KW - Brain Stem

KW - Eating

KW - Gene Expression

KW - Hyperthyroidism

KW - Hypothalamus

KW - Male

KW - Neuropeptides

KW - Rats

KW - Rats, Sprague-Dawley

KW - Sleep

U2 - 10.1016/j.brainres.2012.02.024

DO - 10.1016/j.brainres.2012.02.024

M3 - Article

C2 - 22425186

SN - 0006-8993

VL - 1450

SP - 40

EP - 48

JO - Brain Research

JF - Brain Research

ER -

Hyperthyroidism differentially regulates neuropeptide S system in the rat brain

Abstract

Bibliographical note

Keywords

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