Immune cell infiltrates and prognosis in primary carcinoma of the lung

S K Johnson, K M Kerr, A D Chapman, M M Kennedy, George King, J S Cockburn, R R Jeffrey

    Research output: Contribution to journalArticle

    97 Citations (Scopus)

    Abstract

    The prognostic significance of immune cell infiltrates in surgically resected human lung cancer was investigated in 710 patients, Lymphoid infiltrates were quantified on both standard H&E stained sections and, in a subset of 95 cases. using immunohistochemistry and antibodies to CD3, CD8, CD57, CD68 CD79a and S100 to identify various immune cell types. Subjective grading (low, moderate, high) of lymphoid: cell-infiltrates on H&E sections of tumour and measurement, using image analysis, of overall level of tumour infiltration by any of the immunohistochemically labelled specific immune cell types of the stained sections showed no prognostic significance, However, when a distinction between peritumoural and intratumoural infiltration by particular cell types was made, intratumoural infiltration by high levels of CD3(+) and S100(+) cells was associated with longer post-operative survival (P = 0.02 and P = 0.045, respectively). In lung cancer, subjective assessment of tumour lymphoid infiltration and overall levels of infiltration by particular immune cell types carries no prognostic significance, Intratumoural infiltration by relatively high numbers of CD3(+) T-lymphocytes and Langerhans cells (S100(+)) is associated with a better patient outcome. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)27-35
    Number of pages9
    JournalLung Cancer
    Volume27
    Publication statusPublished - 2000

    Keywords

    • lung cancer
    • lymphocytes
    • Langerhans cells
    • immune reaction
    • prognosis
    • BRONCHOGENIC-CARCINOMA
    • CANCER
    • LYMPHOCYTES
    • STAGE

    Cite this

    Johnson, S. K., Kerr, K. M., Chapman, A. D., Kennedy, M. M., King, G., Cockburn, J. S., & Jeffrey, R. R. (2000). Immune cell infiltrates and prognosis in primary carcinoma of the lung. Lung Cancer, 27, 27-35.

    Immune cell infiltrates and prognosis in primary carcinoma of the lung. / Johnson, S K ; Kerr, K M ; Chapman, A D ; Kennedy, M M ; King, George; Cockburn, J S ; Jeffrey, R R .

    In: Lung Cancer, Vol. 27, 2000, p. 27-35.

    Research output: Contribution to journalArticle

    Johnson, SK, Kerr, KM, Chapman, AD, Kennedy, MM, King, G, Cockburn, JS & Jeffrey, RR 2000, 'Immune cell infiltrates and prognosis in primary carcinoma of the lung' Lung Cancer, vol. 27, pp. 27-35.
    Johnson SK, Kerr KM, Chapman AD, Kennedy MM, King G, Cockburn JS et al. Immune cell infiltrates and prognosis in primary carcinoma of the lung. Lung Cancer. 2000;27:27-35.
    Johnson, S K ; Kerr, K M ; Chapman, A D ; Kennedy, M M ; King, George ; Cockburn, J S ; Jeffrey, R R . / Immune cell infiltrates and prognosis in primary carcinoma of the lung. In: Lung Cancer. 2000 ; Vol. 27. pp. 27-35.
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    abstract = "The prognostic significance of immune cell infiltrates in surgically resected human lung cancer was investigated in 710 patients, Lymphoid infiltrates were quantified on both standard H&E stained sections and, in a subset of 95 cases. using immunohistochemistry and antibodies to CD3, CD8, CD57, CD68 CD79a and S100 to identify various immune cell types. Subjective grading (low, moderate, high) of lymphoid: cell-infiltrates on H&E sections of tumour and measurement, using image analysis, of overall level of tumour infiltration by any of the immunohistochemically labelled specific immune cell types of the stained sections showed no prognostic significance, However, when a distinction between peritumoural and intratumoural infiltration by particular cell types was made, intratumoural infiltration by high levels of CD3(+) and S100(+) cells was associated with longer post-operative survival (P = 0.02 and P = 0.045, respectively). In lung cancer, subjective assessment of tumour lymphoid infiltration and overall levels of infiltration by particular immune cell types carries no prognostic significance, Intratumoural infiltration by relatively high numbers of CD3(+) T-lymphocytes and Langerhans cells (S100(+)) is associated with a better patient outcome. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.",
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    AU - Cockburn, J S

    AU - Jeffrey, R R

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    AB - The prognostic significance of immune cell infiltrates in surgically resected human lung cancer was investigated in 710 patients, Lymphoid infiltrates were quantified on both standard H&E stained sections and, in a subset of 95 cases. using immunohistochemistry and antibodies to CD3, CD8, CD57, CD68 CD79a and S100 to identify various immune cell types. Subjective grading (low, moderate, high) of lymphoid: cell-infiltrates on H&E sections of tumour and measurement, using image analysis, of overall level of tumour infiltration by any of the immunohistochemically labelled specific immune cell types of the stained sections showed no prognostic significance, However, when a distinction between peritumoural and intratumoural infiltration by particular cell types was made, intratumoural infiltration by high levels of CD3(+) and S100(+) cells was associated with longer post-operative survival (P = 0.02 and P = 0.045, respectively). In lung cancer, subjective assessment of tumour lymphoid infiltration and overall levels of infiltration by particular immune cell types carries no prognostic significance, Intratumoural infiltration by relatively high numbers of CD3(+) T-lymphocytes and Langerhans cells (S100(+)) is associated with a better patient outcome. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

    KW - lung cancer

    KW - lymphocytes

    KW - Langerhans cells

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    KW - prognosis

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    KW - CANCER

    KW - LYMPHOCYTES

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