Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD: Protocol of a Real-World Observational Study (PIFotal COPD Study)

Marika Leving; Hans Wouters; Alberto de la Hoz; Sinthia Bosnic-Anticevich; Richard Dekhuijzen; Asparuh Gardev; Federico Lavorini; Jiska Meijer; David Price; Miguel Román Rodríguez; Ioanna Tsiligianni; Omar Usmani; Birgit Wijnsma; Janwillem Kocks

doi:10.1007/s41030-021-00172-7

Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD: Protocol of a Real-World Observational Study (PIFotal COPD Study)

Marika Leving^* (Corresponding Author), Hans Wouters, Alberto de la Hoz, Sinthia Bosnic-Anticevich, Richard Dekhuijzen, Asparuh Gardev, Federico Lavorini, Jiska Meijer, David Price, Miguel Román Rodríguez, Ioanna Tsiligianni, Omar Usmani, Birgit Wijnsma, Janwillem Kocks

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

3 Downloads (Pure)

Abstract

Dry powder inhalers (DPIs), a commonly prescribed inhaler type for respiratory diseases, require patients to generate sufficient peak inspiratory flow (PIF) to ensure optimal drug delivery to the airways. Effectiveness of therapy also requires a good inhalation technique and adequate medication adherence. For patients with chronic obstructive pulmonary disease (COPD), recent studies conducted in tertiary care suggest that DPI users with suboptimal PIF have poorer COPD-related health status and increased exacerbation risk versus those with optimal PIF. The PIFotal study will investigate the impact of PIF, inhalation technique and medication adherence on patient-reported outcomes in patients with COPD in primary care using a DPI for their maintenance therapy.

Original language	English
Pages (from-to)	591-606
Number of pages	16
Journal	Pulmonary Therapy
Volume	7
Issue number	2
Early online date	17 Sept 2021
DOIs	https://doi.org/10.1007/s41030-021-00172-7
Publication status	Published - 1 Dec 2021

Bibliographical note

Acknowledgements
The authors thank Evgeni Dvortsin for his valuable contribution in the initial development of the project.

Funding.
This study was co-funded by Boehringer Ingelheim and GPRI. The study sponsor is GPRI, who will also be performing the data collection and analysis. Boehringer Ingelheim is the funding and scientific partner, and is funding the journal’s Rapid Service fee.

Keywords

Chronic airways disease
Respiratory medicine
Primary care
Quality in healthcare
Protocols and guidelines

Access to Document

10.1007/s41030-021-00172-7Licence: CC BY-NC

Leving_etal_PT_Impact_Of_PIF_VoR
This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.
Final published version, 816 KBLicence: CC BY-NC

Cite this

Leving, M., Wouters, H., de la Hoz, A., Bosnic-Anticevich, S., Dekhuijzen, R., Gardev, A., Lavorini, F., Meijer, J., Price, D., Rodríguez, M. R., Tsiligianni, I., Usmani, O., Wijnsma, B., & Kocks, J. (2021). Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD: Protocol of a Real-World Observational Study (PIFotal COPD Study). Pulmonary Therapy, 7(2), 591-606. https://doi.org/10.1007/s41030-021-00172-7

Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD: Protocol of a Real-World Observational Study (PIFotal COPD Study). / Leving, Marika (Corresponding Author); Wouters, Hans; de la Hoz, Alberto et al.
In: Pulmonary Therapy, Vol. 7, No. 2, 01.12.2021, p. 591-606.

Research output: Contribution to journal › Article › peer-review

Leving, M, Wouters, H, de la Hoz, A, Bosnic-Anticevich, S, Dekhuijzen, R, Gardev, A, Lavorini, F, Meijer, J, Price, D, Rodríguez, MR, Tsiligianni, I, Usmani, O, Wijnsma, B & Kocks, J 2021, 'Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD: Protocol of a Real-World Observational Study (PIFotal COPD Study)', Pulmonary Therapy, vol. 7, no. 2, pp. 591-606. https://doi.org/10.1007/s41030-021-00172-7

@article{950ecf98bfe6423a99bb0968552204d9,

title = "Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD: Protocol of a Real-World Observational Study (PIFotal COPD Study)",

abstract = "Dry powder inhalers (DPIs), a commonly prescribed inhaler type for respiratory diseases, require patients to generate sufficient peak inspiratory flow (PIF) to ensure optimal drug delivery to the airways. Effectiveness of therapy also requires a good inhalation technique and adequate medication adherence. For patients with chronic obstructive pulmonary disease (COPD), recent studies conducted in tertiary care suggest that DPI users with suboptimal PIF have poorer COPD-related health status and increased exacerbation risk versus those with optimal PIF. The PIFotal study will investigate the impact of PIF, inhalation technique and medication adherence on patient-reported outcomes in patients with COPD in primary care using a DPI for their maintenance therapy.",

keywords = "Chronic airways disease, Respiratory medicine, Primary care, Quality in healthcare, Protocols and guidelines",

author = "Marika Leving and Hans Wouters and {de la Hoz}, Alberto and Sinthia Bosnic-Anticevich and Richard Dekhuijzen and Asparuh Gardev and Federico Lavorini and Jiska Meijer and David Price and Rodr{\'i}guez, {Miguel Rom{\'a}n} and Ioanna Tsiligianni and Omar Usmani and Birgit Wijnsma and Janwillem Kocks",

note = "Acknowledgements The authors thank Evgeni Dvortsin for his valuable contribution in the initial development of the project. Funding. This study was co-funded by Boehringer Ingelheim and GPRI. The study sponsor is GPRI, who will also be performing the data collection and analysis. Boehringer Ingelheim is the funding and scientific partner, and is funding the journal{\textquoteright}s Rapid Service fee.",

year = "2021",

month = dec,

day = "1",

doi = "10.1007/s41030-021-00172-7",

language = "English",

volume = "7",

pages = "591--606",

journal = "Pulmonary Therapy",

issn = "2364-1746",

publisher = "Springer ",

number = "2",

}

TY - JOUR

T1 - Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD

T2 - Protocol of a Real-World Observational Study (PIFotal COPD Study)

AU - Leving, Marika

AU - Wouters, Hans

AU - de la Hoz, Alberto

AU - Bosnic-Anticevich, Sinthia

AU - Dekhuijzen, Richard

AU - Gardev, Asparuh

AU - Lavorini, Federico

AU - Meijer, Jiska

AU - Price, David

AU - Rodríguez, Miguel Román

AU - Tsiligianni, Ioanna

AU - Usmani, Omar

AU - Wijnsma, Birgit

AU - Kocks, Janwillem

N1 - Acknowledgements The authors thank Evgeni Dvortsin for his valuable contribution in the initial development of the project. Funding. This study was co-funded by Boehringer Ingelheim and GPRI. The study sponsor is GPRI, who will also be performing the data collection and analysis. Boehringer Ingelheim is the funding and scientific partner, and is funding the journal’s Rapid Service fee.

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Dry powder inhalers (DPIs), a commonly prescribed inhaler type for respiratory diseases, require patients to generate sufficient peak inspiratory flow (PIF) to ensure optimal drug delivery to the airways. Effectiveness of therapy also requires a good inhalation technique and adequate medication adherence. For patients with chronic obstructive pulmonary disease (COPD), recent studies conducted in tertiary care suggest that DPI users with suboptimal PIF have poorer COPD-related health status and increased exacerbation risk versus those with optimal PIF. The PIFotal study will investigate the impact of PIF, inhalation technique and medication adherence on patient-reported outcomes in patients with COPD in primary care using a DPI for their maintenance therapy.

AB - Dry powder inhalers (DPIs), a commonly prescribed inhaler type for respiratory diseases, require patients to generate sufficient peak inspiratory flow (PIF) to ensure optimal drug delivery to the airways. Effectiveness of therapy also requires a good inhalation technique and adequate medication adherence. For patients with chronic obstructive pulmonary disease (COPD), recent studies conducted in tertiary care suggest that DPI users with suboptimal PIF have poorer COPD-related health status and increased exacerbation risk versus those with optimal PIF. The PIFotal study will investigate the impact of PIF, inhalation technique and medication adherence on patient-reported outcomes in patients with COPD in primary care using a DPI for their maintenance therapy.

KW - Chronic airways disease

KW - Respiratory medicine

KW - Primary care

KW - Quality in healthcare

KW - Protocols and guidelines

UR - http://www.scopus.com/inward/record.url?scp=85115050993&partnerID=8YFLogxK

U2 - 10.1007/s41030-021-00172-7

DO - 10.1007/s41030-021-00172-7

M3 - Article

SN - 2364-1746

VL - 7

SP - 591

EP - 606

JO - Pulmonary Therapy

JF - Pulmonary Therapy

IS - 2

ER -

Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD: Protocol of a Real-World Observational Study (PIFotal COPD Study)

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this