Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD: Protocol of a Real-World Observational Study (PIFotal COPD Study)

Marika Leving* (Corresponding Author), Hans Wouters, Alberto de la Hoz, Sinthia Bosnic-Anticevich, Richard Dekhuijzen, Asparuh Gardev, Federico Lavorini, Jiska Meijer, David Price, Miguel Román Rodríguez, Ioanna Tsiligianni, Omar Usmani, Birgit Wijnsma, Janwillem Kocks

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Dry powder inhalers (DPIs), a commonly prescribed inhaler type for respiratory diseases, require patients to generate sufficient peak inspiratory flow (PIF) to ensure optimal drug delivery to the airways. Effectiveness of therapy also requires a good inhalation technique and adequate medication adherence. For patients with chronic obstructive pulmonary disease (COPD), recent studies conducted in tertiary care suggest that DPI users with suboptimal PIF have poorer COPD-related health status and increased exacerbation risk versus those with optimal PIF. The PIFotal study will investigate the impact of PIF, inhalation technique and medication adherence on patient-reported outcomes in patients with COPD in primary care using a DPI for their maintenance therapy.
Original languageEnglish
Number of pages16
JournalPulmonary Therapy
Early online date17 Sep 2021
DOIs
Publication statusE-pub ahead of print - 17 Sep 2021

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