Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD: Protocol of a Real-World Observational Study (PIFotal COPD Study)

Marika Leving; Hans Wouters; Alberto de la Hoz; Sinthia Bosnic-Anticevich; Richard Dekhuijzen; Asparuh Gardev; Federico Lavorini; Jiska Meijer; David Price; Miguel Román Rodríguez; Ioanna Tsiligianni; Omar Usmani; Birgit Wijnsma; Janwillem Kocks

doi:10.1007/s41030-021-00172-7

Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD: Protocol of a Real-World Observational Study (PIFotal COPD Study)

Marika Leving^* (Corresponding Author), Hans Wouters, Alberto de la Hoz, Sinthia Bosnic-Anticevich, Richard Dekhuijzen, Asparuh Gardev, Federico Lavorini, Jiska Meijer, David Price, Miguel Román Rodríguez, Ioanna Tsiligianni, Omar Usmani, Birgit Wijnsma, Janwillem Kocks

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

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Abstract

Dry powder inhalers (DPIs), a commonly prescribed inhaler type for respiratory diseases, require patients to generate sufficient peak inspiratory flow (PIF) to ensure optimal drug delivery to the airways. Effectiveness of therapy also requires a good inhalation technique and adequate medication adherence. For patients with chronic obstructive pulmonary disease (COPD), recent studies conducted in tertiary care suggest that DPI users with suboptimal PIF have poorer COPD-related health status and increased exacerbation risk versus those with optimal PIF. The PIFotal study will investigate the impact of PIF, inhalation technique and medication adherence on patient-reported outcomes in patients with COPD in primary care using a DPI for their maintenance therapy.

Original language	English
Pages (from-to)	591-606
Number of pages	16
Journal	Pulmonary Therapy
Volume	7
Issue number	2
Early online date	17 Sep 2021
DOIs	https://doi.org/10.1007/s41030-021-00172-7
Publication status	Published - 1 Dec 2021

Keywords

Chronic airways disease
Respiratory medicine
Primary care
Quality in healthcare
Protocols and guidelines

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Leving, M., Wouters, H., de la Hoz, A., Bosnic-Anticevich, S., Dekhuijzen, R., Gardev, A., Lavorini, F., Meijer, J., Price, D., Rodríguez, M. R., Tsiligianni, I., Usmani, O., Wijnsma, B., & Kocks, J. (2021). Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD: Protocol of a Real-World Observational Study (PIFotal COPD Study). Pulmonary Therapy, 7(2), 591-606. https://doi.org/10.1007/s41030-021-00172-7

Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD : Protocol of a Real-World Observational Study (PIFotal COPD Study). / Leving, Marika (Corresponding Author); Wouters, Hans; de la Hoz, Alberto et al.

In: Pulmonary Therapy, Vol. 7, No. 2, 01.12.2021, p. 591-606.

Research output: Contribution to journal › Article › peer-review

Leving, M, Wouters, H, de la Hoz, A, Bosnic-Anticevich, S, Dekhuijzen, R, Gardev, A, Lavorini, F, Meijer, J, Price, D, Rodríguez, MR, Tsiligianni, I, Usmani, O, Wijnsma, B & Kocks, J 2021, 'Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD: Protocol of a Real-World Observational Study (PIFotal COPD Study)', Pulmonary Therapy, vol. 7, no. 2, pp. 591-606. https://doi.org/10.1007/s41030-021-00172-7

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abstract = "Dry powder inhalers (DPIs), a commonly prescribed inhaler type for respiratory diseases, require patients to generate sufficient peak inspiratory flow (PIF) to ensure optimal drug delivery to the airways. Effectiveness of therapy also requires a good inhalation technique and adequate medication adherence. For patients with chronic obstructive pulmonary disease (COPD), recent studies conducted in tertiary care suggest that DPI users with suboptimal PIF have poorer COPD-related health status and increased exacerbation risk versus those with optimal PIF. The PIFotal study will investigate the impact of PIF, inhalation technique and medication adherence on patient-reported outcomes in patients with COPD in primary care using a DPI for their maintenance therapy.",

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note = "Acknowledgements The authors thank Evgeni Dvortsin for his valuable contribution in the initial development of the project. Funding. This study was co-funded by Boehringer Ingelheim and GPRI. The study sponsor is GPRI, who will also be performing the data collection and analysis. Boehringer Ingelheim is the funding and scientific partner, and is funding the journal{\textquoteright}s Rapid Service fee.",

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N1 - Acknowledgements The authors thank Evgeni Dvortsin for his valuable contribution in the initial development of the project. Funding. This study was co-funded by Boehringer Ingelheim and GPRI. The study sponsor is GPRI, who will also be performing the data collection and analysis. Boehringer Ingelheim is the funding and scientific partner, and is funding the journal’s Rapid Service fee.

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Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD: Protocol of a Real-World Observational Study (PIFotal COPD Study)

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