Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children's study using the ASQ-3 questionnaire: A prospective birth cohort.

Sumitaka Kobayashi, Sachiko Itoh, Chihiro Miyashita, Yu Ait Bamai, Takeshi Yamaguchi, Hideyuki Masuda, Mariko Itoh, Keiko Yamazaki, Naomi Tamura, Sharon J. B. Hanley, Atsuko Ikeda-Araki, Yasuaki Saijo, Yoshiya Ito, Miyuki Iwai-Shimada, Shin Yamazaki, Michihiro Kamijima, Reiko Kishi* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Neurodevelopmental delay is associated with neurodevelopmental disorders. Prenatal metal exposure can potentially cause neurodevelopmental delays in children. This study examines whether prenatal exposure to mercury (Hg) and selenium (Se) is associated with the risk of neurodevelopmental delays in children up to 4 years of age. Children enrolled in a prospective birth cohort of the Japan Environment and Children's Study were examined. Hg and Se levels in maternal (n(child) = 48,731) and cord (n(child) = 3,083) blood were analyzed by inductively coupled plasma-mass spectrometry. Neurodevelopmental delays were assessed in children between the ages of 0.5 to 4 years using the Ages and Stages Questionnaires, Third Edition. The association between exposure and outcomes was examined using the generalized estimation equation models. In maternal blood, compared to participants with Se levels in the first quartile (83.0 to 
Original languageEnglish
Article number107448
Number of pages10
JournalEnvironment International
Volume168
Early online date4 Aug 2022
DOIs
Publication statusPublished - 1 Oct 2022

Keywords

  • Ages and Stages Questionnaires
  • Japan Environment and Children’s Study
  • Mercury
  • Neurodevelopment
  • Pregnancy
  • Selenium

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