Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children's study using the ASQ-3  questionnaire: A prospective birth cohort.

Sumitaka Kobayashi; Sachiko Itoh; Chihiro Miyashita; Yu Ait Bamai; Takeshi Yamaguchi; Hideyuki Masuda; Mariko Itoh; Keiko Yamazaki; Naomi Tamura; Sharon J. B. Hanley; Atsuko Ikeda-Araki; Yasuaki Saijo; Yoshiya Ito; Miyuki Iwai-Shimada; Shin Yamazaki; Michihiro Kamijima; Reiko Kishi

doi:10.1016/j.envint.2022.107448

Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children's study using the ASQ-3 questionnaire: A prospective birth cohort.

Sumitaka Kobayashi, Sachiko Itoh, Chihiro Miyashita, Yu Ait Bamai, Takeshi Yamaguchi, Hideyuki Masuda, Mariko Itoh, Keiko Yamazaki, Naomi Tamura, Sharon J. B. Hanley, Atsuko Ikeda-Araki, Yasuaki Saijo, Yoshiya Ito, Miyuki Iwai-Shimada, Shin Yamazaki, Michihiro Kamijima, Reiko Kishi^* (Corresponding Author)

^*Corresponding author for this work

Applied Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Neurodevelopmental delay is associated with neurodevelopmental disorders. Prenatal metal exposure can potentially cause neurodevelopmental delays in children. This study examines whether prenatal exposure to mercury (Hg) and selenium (Se) is associated with the risk of neurodevelopmental delays in children up to 4 years of age. Children enrolled in a prospective birth cohort of the Japan Environment and Children's Study were examined. Hg and Se levels in maternal (n(child) = 48,731) and cord (n(child) = 3,083) blood were analyzed by inductively coupled plasma-mass spectrometry. Neurodevelopmental delays were assessed in children between the ages of 0.5 to 4 years using the Ages and Stages Questionnaires, Third Edition. The association between exposure and outcomes was examined using the generalized estimation equation models. In maternal blood, compared to participants with Se levels in the first quartile (83.0 to

Original language	English
Article number	107448
Number of pages	10
Journal	Environment International
Volume	168
Early online date	4 Aug 2022
DOIs	https://doi.org/10.1016/j.envint.2022.107448
Publication status	Published - 1 Oct 2022

Keywords

Ages and Stages Questionnaires
Japan Environment and Children’s Study
Mercury
Neurodevelopment
Pregnancy
Selenium

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Kobayashi, S., Itoh, S., Miyashita, C., Ait Bamai, Y., Yamaguchi, T., Masuda, H., Itoh, M., Yamazaki, K., Tamura, N., Hanley, S. J. B., Ikeda-Araki, A., Saijo, Y., Ito, Y., Iwai-Shimada, M., Yamazaki, S., Kamijima, M., & Kishi, R. (2022). Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children's study using the ASQ-3 questionnaire: A prospective birth cohort. Environment International, 168, [107448]. https://doi.org/10.1016/j.envint.2022.107448

Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children's study using the ASQ-3 questionnaire : A prospective birth cohort. / Kobayashi, Sumitaka; Itoh, Sachiko; Miyashita, Chihiro et al.

In: Environment International, Vol. 168, 107448, 01.10.2022.

Research output: Contribution to journal › Article › peer-review

Kobayashi, S, Itoh, S, Miyashita, C, Ait Bamai, Y, Yamaguchi, T, Masuda, H, Itoh, M, Yamazaki, K, Tamura, N, Hanley, SJB, Ikeda-Araki, A, Saijo, Y, Ito, Y, Iwai-Shimada, M, Yamazaki, S, Kamijima, M & Kishi, R 2022, 'Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children's study using the ASQ-3 questionnaire: A prospective birth cohort.', Environment International, vol. 168, 107448. https://doi.org/10.1016/j.envint.2022.107448

Kobayashi S, Itoh S, Miyashita C, Ait Bamai Y, Yamaguchi T, Masuda H et al. Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children's study using the ASQ-3 questionnaire: A prospective birth cohort. Environment International. 2022 Oct 1;168:107448. Epub 2022 Aug 4. doi: 10.1016/j.envint.2022.107448

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title = "Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children's study using the ASQ-3 questionnaire: A prospective birth cohort.",

abstract = "Neurodevelopmental delay is associated with neurodevelopmental disorders. Prenatal metal exposure can potentially cause neurodevelopmental delays in children. This study examines whether prenatal exposure to mercury (Hg) and selenium (Se) is associated with the risk of neurodevelopmental delays in children up to 4 years of age. Children enrolled in a prospective birth cohort of the Japan Environment and Children's Study were examined. Hg and Se levels in maternal (n(child) = 48,731) and cord (n(child) = 3,083) blood were analyzed by inductively coupled plasma-mass spectrometry. Neurodevelopmental delays were assessed in children between the ages of 0.5 to 4 years using the Ages and Stages Questionnaires, Third Edition. The association between exposure and outcomes was examined using the generalized estimation equation models. In maternal blood, compared to participants with Se levels in the first quartile (83.0 to ",

keywords = "Ages and Stages Questionnaires, Japan Environment and Children{\textquoteright}s Study, Mercury, Neurodevelopment, Pregnancy, Selenium",

author = "Sumitaka Kobayashi and Sachiko Itoh and Chihiro Miyashita and {Ait Bamai}, Yu and Takeshi Yamaguchi and Hideyuki Masuda and Mariko Itoh and Keiko Yamazaki and Naomi Tamura and Hanley, {Sharon J. B.} and Atsuko Ikeda-Araki and Yasuaki Saijo and Yoshiya Ito and Miyuki Iwai-Shimada and Shin Yamazaki and Michihiro Kamijima and Reiko Kishi",

note = "Acknowledgments We thank the participants and their children in the JECS. We wish to express our sincere appreciation to the collaborating hospitals and clinics. We also express our gratitude to all the JECS staff members in Hokkaido, Miyagi, Fukushima, Chiba, Kanagawa, Koshin, Toyama, Aichi, Kyoto, Osaka, Hyogo, Tottori, Kochi, Fukuoka, and MinamiKyushu and Okinawa regional centers and national center for JECS (Programme Office), and the Medical Support Center (Appendix 1). Funding This study was funded by the Ministry of the Environment, Japan. The findings and conclusion of this article are solely the responsibility of the authors and do not represent the official views of the above government. ",

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T1 - Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children's study using the ASQ-3 questionnaire

T2 - A prospective birth cohort.

AU - Kobayashi, Sumitaka

AU - Itoh, Sachiko

AU - Miyashita, Chihiro

AU - Ait Bamai, Yu

AU - Yamaguchi, Takeshi

AU - Masuda, Hideyuki

AU - Itoh, Mariko

AU - Yamazaki, Keiko

AU - Tamura, Naomi

AU - Hanley, Sharon J. B.

AU - Ikeda-Araki, Atsuko

AU - Saijo, Yasuaki

AU - Ito, Yoshiya

AU - Iwai-Shimada, Miyuki

AU - Yamazaki, Shin

AU - Kamijima, Michihiro

AU - Kishi, Reiko

N1 - Acknowledgments We thank the participants and their children in the JECS. We wish to express our sincere appreciation to the collaborating hospitals and clinics. We also express our gratitude to all the JECS staff members in Hokkaido, Miyagi, Fukushima, Chiba, Kanagawa, Koshin, Toyama, Aichi, Kyoto, Osaka, Hyogo, Tottori, Kochi, Fukuoka, and MinamiKyushu and Okinawa regional centers and national center for JECS (Programme Office), and the Medical Support Center (Appendix 1). Funding This study was funded by the Ministry of the Environment, Japan. The findings and conclusion of this article are solely the responsibility of the authors and do not represent the official views of the above government.

PY - 2022/10/1

Y1 - 2022/10/1

N2 - Neurodevelopmental delay is associated with neurodevelopmental disorders. Prenatal metal exposure can potentially cause neurodevelopmental delays in children. This study examines whether prenatal exposure to mercury (Hg) and selenium (Se) is associated with the risk of neurodevelopmental delays in children up to 4 years of age. Children enrolled in a prospective birth cohort of the Japan Environment and Children's Study were examined. Hg and Se levels in maternal (n(child) = 48,731) and cord (n(child) = 3,083) blood were analyzed by inductively coupled plasma-mass spectrometry. Neurodevelopmental delays were assessed in children between the ages of 0.5 to 4 years using the Ages and Stages Questionnaires, Third Edition. The association between exposure and outcomes was examined using the generalized estimation equation models. In maternal blood, compared to participants with Se levels in the first quartile (83.0 to

AB - Neurodevelopmental delay is associated with neurodevelopmental disorders. Prenatal metal exposure can potentially cause neurodevelopmental delays in children. This study examines whether prenatal exposure to mercury (Hg) and selenium (Se) is associated with the risk of neurodevelopmental delays in children up to 4 years of age. Children enrolled in a prospective birth cohort of the Japan Environment and Children's Study were examined. Hg and Se levels in maternal (n(child) = 48,731) and cord (n(child) = 3,083) blood were analyzed by inductively coupled plasma-mass spectrometry. Neurodevelopmental delays were assessed in children between the ages of 0.5 to 4 years using the Ages and Stages Questionnaires, Third Edition. The association between exposure and outcomes was examined using the generalized estimation equation models. In maternal blood, compared to participants with Se levels in the first quartile (83.0 to

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KW - Japan Environment and Children’s Study

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KW - Neurodevelopment

KW - Pregnancy

KW - Selenium

U2 - 10.1016/j.envint.2022.107448

DO - 10.1016/j.envint.2022.107448

M3 - Article

VL - 168

JO - Environment International

JF - Environment International

SN - 0160-4120

M1 - 107448

ER -

Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children's study using the ASQ-3 questionnaire: A prospective birth cohort.

Abstract

Keywords

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