Impaction grafting with a bone-graft substitute in a sheep model of revision hip replacement

M Coathup, N Smith, C Kingsley, T Buckland, R Dattani, G P Ascroft, G Blunn, George Patrick Ashcroft

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

An experimental sheep model was used for impaction allografting of 12 hemiarthroplasty femoral components placed into two equal-sized groups. In group 1, a 50:50 mixture of ApaPore hydroxyapatite bone-graft substitute and allograft was used. In group 2, ApaPore and allograft were mixed in a 90:10 ratio. Both groups were killed at six months. Ground reaction force results demonstrated no significant differences (p > 0.05) between the two groups at 8, 16 and 24 weeks post-operatively, and all animals remained active. The mean bone turnover rates were significantly greater in group 1, at 0.00206 mm/day, compared to group 2 at 0.0013 mm/day (p <0.05). The results for the area of new bone formation demonstrated no significant differences (p > 0.05) between the two groups. No significant differences were found between the two groups in thickness of the cement mantle (p > 0.05) and percentage ApaPore-bone contact (p > 0.05). The results of this animal study demonstrated that a mixture of ApaPore allograft in a 90:10 ratio was comparable to using a 50:50 mixture.
Original languageEnglish
Pages (from-to)246-253
Number of pages8
JournalThe Journal of Bone and Joint Surgery - British volume
Volume90
Issue number2
DOIs
Publication statusPublished - Feb 2008

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Bone Substitutes
Allografts
Hip
Sheep
Transplants
Hemiarthroplasty
Bone Remodeling
Homologous Transplantation
Durapatite
Thigh
Theoretical Models
Bone and Bones

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Impaction grafting with a bone-graft substitute in a sheep model of revision hip replacement. / Coathup, M; Smith, N; Kingsley, C; Buckland, T; Dattani, R; Ascroft, G P; Blunn, G; Ashcroft, George Patrick.

In: The Journal of Bone and Joint Surgery - British volume , Vol. 90, No. 2, 02.2008, p. 246-253.

Research output: Contribution to journalArticle

Coathup, M ; Smith, N ; Kingsley, C ; Buckland, T ; Dattani, R ; Ascroft, G P ; Blunn, G ; Ashcroft, George Patrick. / Impaction grafting with a bone-graft substitute in a sheep model of revision hip replacement. In: The Journal of Bone and Joint Surgery - British volume . 2008 ; Vol. 90, No. 2. pp. 246-253.
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