An experimental sheep model was used for impaction allografting of 12 hemiarthroplasty femoral components placed into two equal-sized groups. In group 1, a 50:50 mixture of ApaPore hydroxyapatite bone-graft substitute and allograft was used. In group 2, ApaPore and allograft were mixed in a 90:10 ratio. Both groups were killed at six months. Ground reaction force results demonstrated no significant differences (p > 0.05) between the two groups at 8, 16 and 24 weeks post-operatively, and all animals remained active. The mean bone turnover rates were significantly greater in group 1, at 0.00206 mm/day, compared to group 2 at 0.0013 mm/day (p <0.05). The results for the area of new bone formation demonstrated no significant differences (p > 0.05) between the two groups. No significant differences were found between the two groups in thickness of the cement mantle (p > 0.05) and percentage ApaPore-bone contact (p > 0.05). The results of this animal study demonstrated that a mixture of ApaPore allograft in a 90:10 ratio was comparable to using a 50:50 mixture.
|Number of pages||8|
|Journal||The Journal of Bone and Joint Surgery - British volume|
|Publication status||Published - Feb 2008|
Coathup, M., Smith, N., Kingsley, C., Buckland, T., Dattani, R., Ascroft, G. P., Blunn, G., & Ashcroft, G. P. (2008). Impaction grafting with a bone-graft substitute in a sheep model of revision hip replacement. The Journal of Bone and Joint Surgery - British volume , 90(2), 246-253. https://doi.org/10.1302/0301-620X.90B2.19675