Abstract
Heart failure is a syndrome of huge and growing importance worldwide. It is widely accepted that the energy status of the myocardium in heart failure is impaired, irrespective of etiology. Agents which modify cardiac substrate utilisation have the potential to ameliorate this energy deficiency by increasing cardiac mechanical efficiency. This may represent a new therapeutic paradigm in heart failure. In this review we discuss existing and new agents that alter cardiac substrate use and summarise the data on clinical efficacy. (C) 2008 Elsevier Inc. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 264-274 |
| Number of pages | 11 |
| Journal | Pharmacology & Therapeutics |
| Volume | 119 |
| Issue number | 3 |
| Early online date | 17 Jun 2008 |
| DOIs | |
| Publication status | Published - Sept 2008 |
Keywords
- myocardial energetics
- heart failure
- metabolic agents
- fatty-acid oxidation
- glucose-insulin-potassium
- left-ventricular function
- activated protein-kinase
- randomized controlled-trial
- percutaneous coronary intervention
- ischemic dilated cardiomyopathy
- elevation myocardial-infarction
- coenzyme-A thiolase
- mitochondrial biogenesis