Improved detection following neuro-eye therapy in patients with post-geniculate brain damage

Arash Sahraie, Mary Joan Macleod, Ceri Tamsin Trevethan, Sian E. Robson, John A. Olson, Paula Callaghan, Brigitte Yip

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Damage to the optic radiation or the occipital cortex results in loss of vision in the contralateral visual Weld, termed partial cortical blindness or hemianopia. Previously, we have demonstrated that stimulation in the Weld defect using visual stimuli with optimal properties for blindsight detection can lead to increases in visual sensitivity within the blind Weld of a group of patients. The present study was aimed to extend the previous work by investigating the eVect of positive feedback on recovery of visual sensitivity. Patients’ abilities for detection of a range of spatial frequencies within their Weld defect were determined using a temporal two-alternative forced-choice technique, before and after a period of visual training (n = 4). Patients underwent Neuro-Eye Therapy which involved detection of temporally modulated spatial grating patches at speciWc retinal locations within their Weld defect. Three patients showed improved detection ability following visual training. Based on our previous studies, we had hypothesised that should the occipital brain lesion extend anteriorly to the thalamus, little recovery would be expected. Here, we describe one such case who showed no improvements after extensive training. The present study provides further evidence that recovery (a) can be gradual
and may require a large number of training sessions (b) can be accelerated using positive feedback and (c) may be less likely to take place if the occipital damage extends anteriorly to the thalamus.
Original languageEnglish
Pages (from-to)25-34
Number of pages10
JournalExperimental Brain Research
Volume206
Issue number1
Early online date19 Aug 2010
DOIs
Publication statusPublished - Sep 2010

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Aptitude
Brain
Thalamus
Cortical Blindness
Hemianopsia
Occipital Lobe
Therapeutics
Radiation

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Improved detection following neuro-eye therapy in patients with post-geniculate brain damage. / Sahraie, Arash; Macleod, Mary Joan; Trevethan, Ceri Tamsin; Robson, Sian E.; Olson, John A.; Callaghan, Paula; Yip, Brigitte.

In: Experimental Brain Research, Vol. 206, No. 1, 09.2010, p. 25-34.

Research output: Contribution to journalArticle

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