Increased left ventricular torsion in uncomplicated type 1 diabetic patients

the role of coronary microvascular function

Ganesh Nallur Shivu, Khalid Abozguia, Tranh Trung Phan, Irfan Ahmed, Rebekah Weaver, Parth Narendran, Martin Stevens, Michael Frenneaux

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

OBJECTIVE - We used speckle tracking echocardiography to study the early changes in left ventricular (LV) torsion in young patients with uncomplicated type 1 diabetes and stress magnetic resonance imaging (MRI) to assess its interrelationships with coronary microangiopathy.

RESEARCH DESIGN AND METHODS - We recruited 33 asymptomatic subjects with type 1 diabetes and 32 age-matched healthy control subjects. All subjects underwent echocardiograms. Stress MRIs were performed in 30 subjects (8 healthy control subjects) to compute myocardial perfusion reserve index (MPRI).

RESULTS - A significant increase in LV torsion (2 +/- 0.7 vs. 1.4 +/- 0.7 degrees/cm, P < 0.05) was identified in longer-term and retinopathy-positive type 1 diabetic subjects (1.9 +/- 0.7 vs. 1.4 +/- 0.7 degrees/cm, P < 0.05) as compared with the healthy control subjects. The MPRI was independently associated with increased LV torsion.

CONCLUSIONS - We demonstrate that LV torsion is increased in young patients with uncomplicated type I diabetes and that coronary microvascular disease may play a key pathophysiological role in the development of increased LV torsion.

Original languageEnglish
Pages (from-to)1710-1712
Number of pages3
JournalDiabetes Care
Volume32
Issue number9
DOIs
Publication statusPublished - Sep 2009

Keywords

  • speckle-tracking echocardiography
  • diastolic dysfunction
  • myocardial-perfusion
  • fraction
  • reserve

Cite this

Increased left ventricular torsion in uncomplicated type 1 diabetic patients : the role of coronary microvascular function. / Shivu, Ganesh Nallur; Abozguia, Khalid; Phan, Tranh Trung; Ahmed, Irfan; Weaver, Rebekah; Narendran, Parth; Stevens, Martin; Frenneaux, Michael.

In: Diabetes Care, Vol. 32, No. 9, 09.2009, p. 1710-1712.

Research output: Contribution to journalArticle

Shivu, GN, Abozguia, K, Phan, TT, Ahmed, I, Weaver, R, Narendran, P, Stevens, M & Frenneaux, M 2009, 'Increased left ventricular torsion in uncomplicated type 1 diabetic patients: the role of coronary microvascular function', Diabetes Care, vol. 32, no. 9, pp. 1710-1712. https://doi.org/10.2337/dc09-0408
Shivu, Ganesh Nallur ; Abozguia, Khalid ; Phan, Tranh Trung ; Ahmed, Irfan ; Weaver, Rebekah ; Narendran, Parth ; Stevens, Martin ; Frenneaux, Michael. / Increased left ventricular torsion in uncomplicated type 1 diabetic patients : the role of coronary microvascular function. In: Diabetes Care. 2009 ; Vol. 32, No. 9. pp. 1710-1712.
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T2 - the role of coronary microvascular function

AU - Shivu, Ganesh Nallur

AU - Abozguia, Khalid

AU - Phan, Tranh Trung

AU - Ahmed, Irfan

AU - Weaver, Rebekah

AU - Narendran, Parth

AU - Stevens, Martin

AU - Frenneaux, Michael

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N2 - OBJECTIVE - We used speckle tracking echocardiography to study the early changes in left ventricular (LV) torsion in young patients with uncomplicated type 1 diabetes and stress magnetic resonance imaging (MRI) to assess its interrelationships with coronary microangiopathy.RESEARCH DESIGN AND METHODS - We recruited 33 asymptomatic subjects with type 1 diabetes and 32 age-matched healthy control subjects. All subjects underwent echocardiograms. Stress MRIs were performed in 30 subjects (8 healthy control subjects) to compute myocardial perfusion reserve index (MPRI).RESULTS - A significant increase in LV torsion (2 +/- 0.7 vs. 1.4 +/- 0.7 degrees/cm, P < 0.05) was identified in longer-term and retinopathy-positive type 1 diabetic subjects (1.9 +/- 0.7 vs. 1.4 +/- 0.7 degrees/cm, P < 0.05) as compared with the healthy control subjects. The MPRI was independently associated with increased LV torsion.CONCLUSIONS - We demonstrate that LV torsion is increased in young patients with uncomplicated type I diabetes and that coronary microvascular disease may play a key pathophysiological role in the development of increased LV torsion.

AB - OBJECTIVE - We used speckle tracking echocardiography to study the early changes in left ventricular (LV) torsion in young patients with uncomplicated type 1 diabetes and stress magnetic resonance imaging (MRI) to assess its interrelationships with coronary microangiopathy.RESEARCH DESIGN AND METHODS - We recruited 33 asymptomatic subjects with type 1 diabetes and 32 age-matched healthy control subjects. All subjects underwent echocardiograms. Stress MRIs were performed in 30 subjects (8 healthy control subjects) to compute myocardial perfusion reserve index (MPRI).RESULTS - A significant increase in LV torsion (2 +/- 0.7 vs. 1.4 +/- 0.7 degrees/cm, P < 0.05) was identified in longer-term and retinopathy-positive type 1 diabetic subjects (1.9 +/- 0.7 vs. 1.4 +/- 0.7 degrees/cm, P < 0.05) as compared with the healthy control subjects. The MPRI was independently associated with increased LV torsion.CONCLUSIONS - We demonstrate that LV torsion is increased in young patients with uncomplicated type I diabetes and that coronary microvascular disease may play a key pathophysiological role in the development of increased LV torsion.

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