Preparative RP-HPLC analysis of a methanol extract of the seeds of Centaurea cyanus afforded four indole alkaloids: moschamine, cis-moschamine, centcyamine and cis-centcyamine, the latter two being new natural products. Structures of these compounds were elucidated by comprehensive spectroscopic analyses. General toxicity of the isolates was determined by Brine Shrimp Lethality bioassay. (C) 2001 Elsevier Science Ltd. All rights reserved.
- Centaurea cyanus
- Brine Shrimp Lethality bioassay
- Artemia saliva