Infants with flow limitation at 4 weeks: Outcome at 6 and 11 years

Stephen William Turner, L. L. Palmer, P. J. Rye, N. A. Gibson, P. K. Judge, S. Young, L. I. Landau, P. N. Le Souef

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Within a longitudinal study of lung function in 243 infants, we identified a group of 23 individuals with flow limitation in tidal expiration. In infancy, flow-limited children have reduced lung function and increased airway responsiveness (AR), and at 2 years of age they are diagnosed with asthma more frequently. We hypothesized that these observations would persist throughout childhood. Data from ages 3 to 11 years were analyzed. Only at 4 years of age did the flow-limited group have increased wheeze compared with other cohort members (odds ratio, 4.25; 95% confidence interval [CI], 1.11 to 16.2; p = 0.04; n = 114). At 6 years of age, 117 cohort members were seen. The flow-limited group (n = 14) had greater AR (p = 0.009) and reduced mean FEV1 (131 ml; 95% CI, 16 to 246; p = 0.03) and FEF25-75 (0.28 L/second; 95% CI, 0.05 to 0.52; p = 0.02). At 11 years of age, 183 children were seen and the flow-limited group (n = 18) had greater AR (p = 0.02) and a trend toward reduced mean FEF25-75 (0.24 L/second; 95% CI, -0.02 to 0.49; p = 0.08). Atopy and parental asthma were not increased in the flow-limited group. We suggest that the physiologic abnormality that causes flow limitation in early infancy may identify an at-risk group, different from asthma, who have reduced lung function and increased airway responsiveness in later life.

Original languageEnglish
Pages (from-to)1294-1298
Number of pages4
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume165
Issue number9
DOIs
Publication statusPublished - May 2002

Keywords

  • bronchial hyperreactivity
  • child
  • longitudinal studies
  • respiratory function tests
  • AIRWAY RESPONSIVENESS
  • LUNG-FUNCTION
  • BRONCHIAL RESPONSIVENESS
  • PULMONARY-FUNCTION
  • CHILDHOOD ASTHMA
  • RISK FACTOR
  • LIFE
  • METHACHOLINE
  • CHILDREN
  • HYPERRESPONSIVENESS

Cite this

Turner, S. W., Palmer, L. L., Rye, P. J., Gibson, N. A., Judge, P. K., Young, S., ... Le Souef, P. N. (2002). Infants with flow limitation at 4 weeks: Outcome at 6 and 11 years. American Journal of Respiratory and Critical Care Medicine, 165(9), 1294-1298. https://doi.org/10.1164/rccm.200110-018OC

Infants with flow limitation at 4 weeks: Outcome at 6 and 11 years. / Turner, Stephen William; Palmer, L. L.; Rye, P. J.; Gibson, N. A.; Judge, P. K.; Young, S.; Landau, L. I.; Le Souef, P. N.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 165, No. 9, 05.2002, p. 1294-1298.

Research output: Contribution to journalArticle

Turner, SW, Palmer, LL, Rye, PJ, Gibson, NA, Judge, PK, Young, S, Landau, LI & Le Souef, PN 2002, 'Infants with flow limitation at 4 weeks: Outcome at 6 and 11 years', American Journal of Respiratory and Critical Care Medicine, vol. 165, no. 9, pp. 1294-1298. https://doi.org/10.1164/rccm.200110-018OC
Turner, Stephen William ; Palmer, L. L. ; Rye, P. J. ; Gibson, N. A. ; Judge, P. K. ; Young, S. ; Landau, L. I. ; Le Souef, P. N. / Infants with flow limitation at 4 weeks: Outcome at 6 and 11 years. In: American Journal of Respiratory and Critical Care Medicine. 2002 ; Vol. 165, No. 9. pp. 1294-1298.
@article{2baf92b883d74660a5d7b53ae0ecd5d3,
title = "Infants with flow limitation at 4 weeks: Outcome at 6 and 11 years",
abstract = "Within a longitudinal study of lung function in 243 infants, we identified a group of 23 individuals with flow limitation in tidal expiration. In infancy, flow-limited children have reduced lung function and increased airway responsiveness (AR), and at 2 years of age they are diagnosed with asthma more frequently. We hypothesized that these observations would persist throughout childhood. Data from ages 3 to 11 years were analyzed. Only at 4 years of age did the flow-limited group have increased wheeze compared with other cohort members (odds ratio, 4.25; 95{\%} confidence interval [CI], 1.11 to 16.2; p = 0.04; n = 114). At 6 years of age, 117 cohort members were seen. The flow-limited group (n = 14) had greater AR (p = 0.009) and reduced mean FEV1 (131 ml; 95{\%} CI, 16 to 246; p = 0.03) and FEF25-75 (0.28 L/second; 95{\%} CI, 0.05 to 0.52; p = 0.02). At 11 years of age, 183 children were seen and the flow-limited group (n = 18) had greater AR (p = 0.02) and a trend toward reduced mean FEF25-75 (0.24 L/second; 95{\%} CI, -0.02 to 0.49; p = 0.08). Atopy and parental asthma were not increased in the flow-limited group. We suggest that the physiologic abnormality that causes flow limitation in early infancy may identify an at-risk group, different from asthma, who have reduced lung function and increased airway responsiveness in later life.",
keywords = "bronchial hyperreactivity, child, longitudinal studies, respiratory function tests, AIRWAY RESPONSIVENESS, LUNG-FUNCTION, BRONCHIAL RESPONSIVENESS, PULMONARY-FUNCTION, CHILDHOOD ASTHMA, RISK FACTOR, LIFE, METHACHOLINE, CHILDREN, HYPERRESPONSIVENESS",
author = "Turner, {Stephen William} and Palmer, {L. L.} and Rye, {P. J.} and Gibson, {N. A.} and Judge, {P. K.} and S. Young and Landau, {L. I.} and {Le Souef}, {P. N.}",
year = "2002",
month = "5",
doi = "10.1164/rccm.200110-018OC",
language = "English",
volume = "165",
pages = "1294--1298",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society - AJRCCM",
number = "9",

}

TY - JOUR

T1 - Infants with flow limitation at 4 weeks: Outcome at 6 and 11 years

AU - Turner, Stephen William

AU - Palmer, L. L.

AU - Rye, P. J.

AU - Gibson, N. A.

AU - Judge, P. K.

AU - Young, S.

AU - Landau, L. I.

AU - Le Souef, P. N.

PY - 2002/5

Y1 - 2002/5

N2 - Within a longitudinal study of lung function in 243 infants, we identified a group of 23 individuals with flow limitation in tidal expiration. In infancy, flow-limited children have reduced lung function and increased airway responsiveness (AR), and at 2 years of age they are diagnosed with asthma more frequently. We hypothesized that these observations would persist throughout childhood. Data from ages 3 to 11 years were analyzed. Only at 4 years of age did the flow-limited group have increased wheeze compared with other cohort members (odds ratio, 4.25; 95% confidence interval [CI], 1.11 to 16.2; p = 0.04; n = 114). At 6 years of age, 117 cohort members were seen. The flow-limited group (n = 14) had greater AR (p = 0.009) and reduced mean FEV1 (131 ml; 95% CI, 16 to 246; p = 0.03) and FEF25-75 (0.28 L/second; 95% CI, 0.05 to 0.52; p = 0.02). At 11 years of age, 183 children were seen and the flow-limited group (n = 18) had greater AR (p = 0.02) and a trend toward reduced mean FEF25-75 (0.24 L/second; 95% CI, -0.02 to 0.49; p = 0.08). Atopy and parental asthma were not increased in the flow-limited group. We suggest that the physiologic abnormality that causes flow limitation in early infancy may identify an at-risk group, different from asthma, who have reduced lung function and increased airway responsiveness in later life.

AB - Within a longitudinal study of lung function in 243 infants, we identified a group of 23 individuals with flow limitation in tidal expiration. In infancy, flow-limited children have reduced lung function and increased airway responsiveness (AR), and at 2 years of age they are diagnosed with asthma more frequently. We hypothesized that these observations would persist throughout childhood. Data from ages 3 to 11 years were analyzed. Only at 4 years of age did the flow-limited group have increased wheeze compared with other cohort members (odds ratio, 4.25; 95% confidence interval [CI], 1.11 to 16.2; p = 0.04; n = 114). At 6 years of age, 117 cohort members were seen. The flow-limited group (n = 14) had greater AR (p = 0.009) and reduced mean FEV1 (131 ml; 95% CI, 16 to 246; p = 0.03) and FEF25-75 (0.28 L/second; 95% CI, 0.05 to 0.52; p = 0.02). At 11 years of age, 183 children were seen and the flow-limited group (n = 18) had greater AR (p = 0.02) and a trend toward reduced mean FEF25-75 (0.24 L/second; 95% CI, -0.02 to 0.49; p = 0.08). Atopy and parental asthma were not increased in the flow-limited group. We suggest that the physiologic abnormality that causes flow limitation in early infancy may identify an at-risk group, different from asthma, who have reduced lung function and increased airway responsiveness in later life.

KW - bronchial hyperreactivity

KW - child

KW - longitudinal studies

KW - respiratory function tests

KW - AIRWAY RESPONSIVENESS

KW - LUNG-FUNCTION

KW - BRONCHIAL RESPONSIVENESS

KW - PULMONARY-FUNCTION

KW - CHILDHOOD ASTHMA

KW - RISK FACTOR

KW - LIFE

KW - METHACHOLINE

KW - CHILDREN

KW - HYPERRESPONSIVENESS

U2 - 10.1164/rccm.200110-018OC

DO - 10.1164/rccm.200110-018OC

M3 - Article

VL - 165

SP - 1294

EP - 1298

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 9

ER -