Inhibition and Reversal of Denervation-Induced Atrophy by the Beta-Agonist Growth Promoter, Clenbuterol

C A Maltin, P J Reeds, Margaret Inkster Delday, Susan Hay, F G Smith, Gerald Lobley

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Abstract

Dietary administration of the growth promoter, clenbuterol, ameliorated denervation-induced atrophy in rat soleus muscles. In acutely denervated muscles the drug inhibited the appearance of atrophy, and in chronically denervated muscles the atrophy was almost fully reversed. Responses in slow twitch oxidative fibres were particularly marked.
Original languageEnglish
Pages (from-to)811-818
Number of pages8
JournalBioscience Reports
Volume6
Issue number9
DOIs
Publication statusPublished - Sep 1986

Keywords

  • muscle
  • protein degradation
  • clenbuterol
  • denervation-induced atrophy

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