Inhibition and Reversal of Denervation-Induced Atrophy by the Beta-Agonist Growth Promoter, Clenbuterol

C A  Maltin; P J  Reeds; Margaret Inkster Delday; Susan Hay; F G  Smith; Gerald Lobley

doi:10.1007/BF01117104

Inhibition and Reversal of Denervation-Induced Atrophy by the Beta-Agonist Growth Promoter, Clenbuterol

C A Maltin, P J Reeds, Margaret Inkster Delday, Susan Hay, F G Smith, Gerald Lobley

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Dietary administration of the growth promoter, clenbuterol, ameliorated denervation-induced atrophy in rat soleus muscles. In acutely denervated muscles the drug inhibited the appearance of atrophy, and in chronically denervated muscles the atrophy was almost fully reversed. Responses in slow twitch oxidative fibres were particularly marked.

Original language	English
Pages (from-to)	811-818
Number of pages	8
Journal	Bioscience Reports
Volume	6
Issue number	9
DOIs	https://doi.org/10.1007/BF01117104
Publication status	Published - Sep 1986

Keywords

muscle
protein degradation
clenbuterol
denervation-induced atrophy

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10.1007/BF01117104

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title = "Inhibition and Reversal of Denervation-Induced Atrophy by the Beta-Agonist Growth Promoter, Clenbuterol",

abstract = "Dietary administration of the growth promoter, clenbuterol, ameliorated denervation-induced atrophy in rat soleus muscles. In acutely denervated muscles the drug inhibited the appearance of atrophy, and in chronically denervated muscles the atrophy was almost fully reversed. Responses in slow twitch oxidative fibres were particularly marked.",

keywords = "muscle, protein degradation, clenbuterol, denervation-induced atrophy",

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T1 - Inhibition and Reversal of Denervation-Induced Atrophy by the Beta-Agonist Growth Promoter, Clenbuterol

AU - Maltin, C A

AU - Reeds, P J

AU - Delday, Margaret Inkster

AU - Hay, Susan

AU - Smith, F G

AU - Lobley, Gerald

PY - 1986/9

Y1 - 1986/9

N2 - Dietary administration of the growth promoter, clenbuterol, ameliorated denervation-induced atrophy in rat soleus muscles. In acutely denervated muscles the drug inhibited the appearance of atrophy, and in chronically denervated muscles the atrophy was almost fully reversed. Responses in slow twitch oxidative fibres were particularly marked.

AB - Dietary administration of the growth promoter, clenbuterol, ameliorated denervation-induced atrophy in rat soleus muscles. In acutely denervated muscles the drug inhibited the appearance of atrophy, and in chronically denervated muscles the atrophy was almost fully reversed. Responses in slow twitch oxidative fibres were particularly marked.

KW - muscle

KW - protein degradation

KW - clenbuterol

KW - denervation-induced atrophy

U2 - 10.1007/BF01117104

DO - 10.1007/BF01117104

M3 - Article

VL - 6

SP - 811

EP - 818

JO - Bioscience Reports

JF - Bioscience Reports

SN - 0144-8463

IS - 9

ER -

Inhibition and Reversal of Denervation-Induced Atrophy by the Beta-Agonist Growth Promoter, Clenbuterol

Abstract

Keywords

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