Insights from the shell proteome: Biomineralization to adaptation

J. Arivalagan, T. Yarra, B. Marie, V.A. Sleight, E. Duvernois-Berthet, M.S. Clark, A. Marie (Corresponding Author), S. Berland

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Bivalves have evolved a range of complex shell forming mechanisms that are reflected by their incredible diversity in shell mineralogy and microstructures. A suite of proteins exported to the shell matrix space plays a significant role in
controlling these features, in addition to underpinning some of the physical properties of the shell itself. Although, there is a general consensus that a minimum basic protein tool kit is required for shell construction, to date, this remains undefined. In this study, the shell matrix proteins (SMPs) of four highly divergent bivalves (The Pacific oyster, Crassostrea gigas; the blue mussel, Mytilus edulis; the clam, Mya truncata, and the king scallop, Pecten maximus) were analyzed in an identical fashion using proteomics pipeline. This enabled us to identify the critical elements of a “basic tool kit” for calcification processes, which were conserved across the taxa irrespective of the shell morphology and arrangement of the crystal surfaces. In addition, protein domains controlling the crystal layers specific to aragonite and calcite were also identified. Intriguingly, a significant number of the identified SMPs contained domains related to immune functions. These were often are unique to each species implying their involvement not only in immunity, but also environmental adaptation. This suggests that the SMPs are selectively exported in a complex mix to endow the shell with both mechanical protection and biochemical defense.
Original languageEnglish
Pages (from-to)66-77
Number of pages12
JournalMolecular Biology and Evolution
Volume34
Issue number1
Early online date16 Oct 2016
DOIs
Publication statusPublished - Jan 2017

Keywords

  • biomineralization
  • shell matrix proteins
  • calcification
  • calcite
  • aragonite
  • evolution

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    Arivalagan, J., Yarra, T., Marie, B., Sleight, V. A., Duvernois-Berthet, E., Clark, M. S., Marie, A., & Berland, S. (2017). Insights from the shell proteome: Biomineralization to adaptation. Molecular Biology and Evolution, 34(1), 66-77. https://doi.org/10.1093/molbev/msw219