Inter-individual responses to sprint interval training, a pilot study investigating interactions with the sirtuin system

Stuart R. Gray; Tom P. Aird; Andrew J. Farquharson; Graham W. Horgan; Emily Fisher; John Wilson; Gareth E. Hopkins; Bradley Anderson; Syed A. Ahmad; Stuart R. Davis; Janice E. Drew

doi:10.1139/apnm-2017-0224

Inter-individual responses to sprint interval training, a pilot study investigating interactions with the sirtuin system

Stuart R. Gray, Tom P. Aird, Andrew J. Farquharson, Graham W. Horgan, Emily Fisher, John Wilson, Gareth E. Hopkins, Bradley Anderson, Syed A. Ahmad, Stuart R. Davis, Janice E. Drew

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Article › peer-review

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Abstract

Sprint intensity interval training (SIT) is reported to improve blood glucose control and may be a useful public health tool. The sirtuins and associated genes are emerging as key players in blood glucose control. This study investigated the interplay between the sirtuin/NAD system and individual variation in insulin sensitivity responses after SIT in young healthy individuals. Before and after 4 weeks of SIT body mass and fat percentage were measured and oral glucose tolerance tests (OGTT) performed in 20 young healthy participants (7 females). Blood gene expression profiles (all 7 mammalian sirtuin genes and 15 enzymes
involved in conversion of tryptophan, bioavailable vitamin B3 and metabolic precursors to NAD). NAD/NADP was measured in whole blood. Significant reductions in body weight and body fat post-SIT were associated with altered lipid profiles, NAD/NADP and regulation of components of the sirtuin/NAD system (NAMPT, NMNAT1, CD38 and ABCA1). Variable improvements in measured metabolic health parameters were evident and attributed to different responses in males and females, together with marked inter-individual variation in responses of the sirtuin/NAD system to SIT.

Original language	English
Pages (from-to)	84-93
Number of pages	10
Journal	Applied Physiology Nutrition and Metabolism / Physiologie Appliquée, Nutrition et Métabolisme
Volume	43
Issue number	1
Early online date	13 Sep 2017
DOIs	https://doi.org/10.1139/apnm-2017-0224
Publication status	Published - Jan 2018

Keywords

insulin sensitivity
interval exercise
body composition
sirtuin system
inter-individual variation
GeXP

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Gray, S. R., Aird, T. P., Farquharson, A. J., Horgan, G. W., Fisher, E., Wilson, J., Hopkins, G. E., Anderson, B., Ahmad, S. A., Davis, S. R., & Drew, J. E. (2018). Inter-individual responses to sprint interval training, a pilot study investigating interactions with the sirtuin system. Applied Physiology Nutrition and Metabolism / Physiologie Appliquée, Nutrition et Métabolisme, 43(1), 84-93. https://doi.org/10.1139/apnm-2017-0224

Inter-individual responses to sprint interval training, a pilot study investigating interactions with the sirtuin system. / Gray, Stuart R.; Aird, Tom P.; Farquharson, Andrew J. et al.

In: Applied Physiology Nutrition and Metabolism / Physiologie Appliquée, Nutrition et Métabolisme, Vol. 43, No. 1, 01.2018, p. 84-93.

Research output: Contribution to journal › Article › peer-review

Gray, SR, Aird, TP, Farquharson, AJ , Horgan, GW, Fisher, E, Wilson, J, Hopkins, GE, Anderson, B, Ahmad, SA, Davis, SR & Drew, JE 2018, 'Inter-individual responses to sprint interval training, a pilot study investigating interactions with the sirtuin system', Applied Physiology Nutrition and Metabolism / Physiologie Appliquée, Nutrition et Métabolisme, vol. 43, no. 1, pp. 84-93. https://doi.org/10.1139/apnm-2017-0224

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abstract = "Sprint intensity interval training (SIT) is reported to improve blood glucose control and may be a useful public health tool. The sirtuins and associated genes are emerging as key players in blood glucose control. This study investigated the interplay between the sirtuin/NAD system and individual variation in insulin sensitivity responses after SIT in young healthy individuals. Before and after 4 weeks of SIT body mass and fat percentage were measured and oral glucose tolerance tests (OGTT) performed in 20 young healthy participants (7 females). Blood gene expression profiles (all 7 mammalian sirtuin genes and 15 enzymes involved in conversion of tryptophan, bioavailable vitamin B3 and metabolic precursors to NAD). NAD/NADP was measured in whole blood. Significant reductions in body weight and body fat post-SIT were associated with altered lipid profiles, NAD/NADP and regulation of components of the sirtuin/NAD system (NAMPT, NMNAT1, CD38 and ABCA1). Variable improvements in measured metabolic health parameters were evident and attributed to different responses in males and females, together with marked inter-individual variation in responses of the sirtuin/NAD system to SIT.",

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author = "Gray, {Stuart R.} and Aird, {Tom P.} and Farquharson, {Andrew J.} and Horgan, {Graham W.} and Emily Fisher and John Wilson and Hopkins, {Gareth E.} and Bradley Anderson and Ahmad, {Syed A.} and Davis, {Stuart R.} and Drew, {Janice E.}",

note = "Acknowledgements We thank the Human Nutrition and Genomics Units, Rowett Institute, University of Aberdeen for technical support. This work was supported by the Scottish Government's Rural and Environment Science and Analytical Services Division and an NHS Grampian Endowment Fund grant.",

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Inter-individual responses to sprint interval training, a pilot study investigating interactions with the sirtuin system

Abstract

Keywords

UN SDGs

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