Inter-individual responses to sprint interval training, a pilot study investigating interactions with the sirtuin system

Stuart R. Gray, Tom P. Aird, Andrew J. Farquharson, Graham W. Horgan, Emily Fisher, John Wilson, Gareth E. Hopkins, Bradley Anderson, Syed A. Ahmad, Stuart R. Davis, Janice E. Drew

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9 Citations (Scopus)
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Sprint intensity interval training (SIT) is reported to improve blood glucose control and may be a useful public health tool. The sirtuins and associated genes are emerging as key players in blood glucose control. This study investigated the interplay between the sirtuin/NAD system and individual variation in insulin sensitivity responses after SIT in young healthy individuals. Before and after 4 weeks of SIT body mass and fat percentage were measured and oral glucose tolerance tests (OGTT) performed in 20 young healthy participants (7 females). Blood gene expression profiles (all 7 mammalian sirtuin genes and 15 enzymes
involved in conversion of tryptophan, bioavailable vitamin B3 and metabolic precursors to NAD). NAD/NADP was measured in whole blood. Significant reductions in body weight and body fat post-SIT were associated with altered lipid profiles, NAD/NADP and regulation of components of the sirtuin/NAD system (NAMPT, NMNAT1, CD38 and ABCA1). Variable improvements in measured metabolic health parameters were evident and attributed to different responses in males and females, together with marked inter-individual variation in responses of the sirtuin/NAD system to SIT.
Original languageEnglish
Pages (from-to)84-93
Number of pages10
JournalApplied Physiology Nutrition and Metabolism / Physiologie Appliquée, Nutrition et Métabolisme
Issue number1
Early online date13 Sep 2017
Publication statusPublished - Jan 2018


  • insulin sensitivity
  • interval exercise
  • body composition
  • sirtuin system
  • inter-individual variation
  • GeXP


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